{"id":108276,"date":"2024-09-29T08:48:44","date_gmt":"2024-09-29T01:48:44","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=108276"},"modified":"2024-09-29T08:48:44","modified_gmt":"2024-09-29T01:48:44","slug":"government-scientist-faked-images-published-in-alzheimers-research-papers","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=108276","title":{"rendered":"Government scientist &#8216;faked images published in Alzheimer&#8217;s research papers&#8217;"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div data-test=\"article-body-text\">\n<p>A\u00a0US government scientist may have published faked images in <a class=\"ck-custom-link\" href=\"https:\/\/www.telegraph.co.uk\/health-fitness\/conditions\/dementia\/risk-factors-for-dementia-you-can-do-something-about\/\">papers on Alzheimer\u2019s<\/a>, a report has claimed.<\/p>\n<p>Eliezer Masliah, who led the neuroscience division at the National Institute on Aging, a government health body, has been a key figure in Alzheimer\u2019s and Parkinson\u2019s disease research for decades.<\/p>\n<p>But an investigation by the National Institutes of Health (NIH) has made \u201cfindings of research misconduct\u201d against Dr Masliah for \u201cfalsification and\/or fabrication\u201d of figure panels which were used to show <a class=\"ck-custom-link\" href=\"https:\/\/www.telegraph.co.uk\/health-fitness\/conditions\/dementia\/dementia-treatments-medication-drugs-lifestyle\/\">experimental results<\/a>.<\/p>\n<p>According to the academic journal Science, which conducted its own investigation into Dr Masliah, he may have also doctored pictures used in several research\u00a0papers.<\/p>\n<p>\u201cAll four [papers] used apparently doctored images, according to the dossier, as did other Masliah papers cited in clinical trial reports as important to [Parkinson\u2019s disease treatment] prasinezumab\u2019s development,\u201d Science reported.<\/p>\n<p>The falsification is claimed to include the \u201cduplication of the same image with different captions about different research in different journals\u201d.<\/p>\n<p>According to the NIH, misconduct may have occurred in two studies co-authored by Dr Masliah.<\/p>\n<h2 class=\"u-heading-size-medium u-heading-style-normal\">\u2018Falsification and fabrication\u2019<\/h2>\n<p>In a statement, the NIH said: \u201cFollowing an investigation, the National Institutes of Health has made findings of research misconduct against Eliezer Masliah, M.D., due to falsification and\/or fabrication involving re-use and relabel of figure panels representing different experimental results in two publications.<\/p>\n<p>\u201cNIH will notify the two journals of its findings so that appropriate action can be taken.<\/p>\n<p>\u201cNIH initiated its research misconduct review process in May 2023 after it received allegations from the HHS Office of Research Integrity (ORI) that same month. NIH began its investigation phase in December 2023, concluded its investigation of these allegations on Sept 15, 2024, and notified HHS ORI of its findings.\u201d<\/p>\n<p>Science\u2019s\u00a0investigation, which was published days after the NIH\u2019s findings, alleged that \u201cscores\u201d of Dr Masliah\u2019s lab studies were \u201criddled with\u201d apparently manipulated images.<\/p>\n<p>The journal reportedly brought its findings to a neuroscientist and forensic analysts who later asserted that more than 100 of Dr Masliah\u2019s published studies, spanning more than two decades, contained a \u201csteady stream of suspect images\u201d.<\/p>\n<p>Dr Masliah, a former professor at the University of California San Diego, was appointed to head the National Institute on Aging in 2016, when Congress significantly <a class=\"ck-custom-link\" href=\"https:\/\/www.telegraph.co.uk\/health-fitness\/conditions\/cancer\/new-medical-tests\/\">increased funding for Alzheimer\u2019s research<\/a>.<\/p>\n<p>Dr Masliah\u2019s department had a budget of $2.6 billion, making him one of the most influential figures in neuroscience, with the power to set research priorities within the field.<\/p>\n<p>His own research, amounting to around 800 papers, particularly on proteins such as alpha-synuclein linked to Alzheimer\u2019s and Parkinson\u2019s, has been widely cited and drawn upon in clinical and drug development efforts.<\/p>\n<h2 class=\"u-heading-size-medium u-heading-style-normal\">\u2018Anomalous data\u2019<\/h2>\n<p>However, experts quoted by Science allege that much of the research they analysed contained a \u201cpattern of anomalous data\u201d which they say warrants further investigation.<\/p>\n<p>A forensic review led by neuroscientist Matthew Schrag, image analyst Kevin Patrick, and others identified issues in 132 papers published between 1997 and 2023. The team found allegedly manipulated western blots \u2013 images used to detect proteins \u2013 and allegedly altered micrographs of brain tissue.<\/p>\n<p>In some instances, images were apparently duplicated across different studies that had been published years apart, with conflicting experimental conditions.<\/p>\n<p>The apparently manipulated images raise questions about the calibre and integrity of Dr Masliah\u2019s research, Mu Yang, a Columbia University neurobiologist who analysed parts of Dr Masliah\u2019s published work, told Science.<\/p>\n<p>Dr Masliah\u2019s work has played an important role in advancing drug trials, including for prasinezumab.<\/p>\n<p>His research also helped to secure approval from the US Food and Drug Administration to conduct clinical trials for the drug.<\/p>\n<h2 class=\"u-heading-size-medium u-heading-style-normal\">Side effects<\/h2>\n<p>However, results from a 2022 trial of prasinezumab revealed no significant benefit in treating Parkinson\u2019s.<\/p>\n<p>The 300-page dossier on apparently manipulated images in parts of Dr Masliah\u2019s research \u201cstunned 11 neuroscientists who agreed to review it\u201d, according to Science.<\/p>\n<p>Christian Haass, of the Ludwig Maximilian University of Munich, said: \u201cPeople will, of course, be shocked, as I was\u2026 I was falling from a chair, basically.\u201d<\/p>\n<p>While the researchers \u201cdidn\u2019t personally verify every example of possible misconduct,\u201d Science reported that they \u201cagreed that most of the suspect work cannot reasonably be explained as careless errors or publishing anomalies\u201d.<\/p>\n<p>Samuel Gandy, a neurologist at the Mount Sinai Alzheimer\u2019s Disease Research Center, was \u201cvisibly shaken during a video interview\u201d with Science when discussing the dossier, according to the journal.<\/p>\n<p>\u201cI\u2019m floored,\u201d Dr Gandy said. \u201cHundreds of images. There had to have been ongoing manipulation for years.\u201d<\/p>\n<p>Dr Masliah and the institutions affiliated with his work, such as the NIH and the University of California San Diego, have not yet publicly challenged the findings in the dossier, according to Science.<\/p>\n<p>Dr Masliah and the NIH were contacted for comment.<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.telegraph.co.uk\/us\/news\/2024\/09\/28\/government-scientist-faked-images-alzheimers-research-paper\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A\u00a0US government scientist may have published faked images in papers on Alzheimer\u2019s, a report has claimed. Eliezer Masliah, who led the neuroscience division at the National Institute on Aging, a &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=108276\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-108276","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/108276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=108276"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/108276\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=108276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=108276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=108276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}