{"id":109972,"date":"2024-10-03T16:30:18","date_gmt":"2024-10-03T09:30:18","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=109972"},"modified":"2024-10-03T16:30:18","modified_gmt":"2024-10-03T09:30:18","slug":"cdc-testing-of-missouris-bird-flu-case-hits-obstacles-delaying-answers","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=109972","title":{"rendered":"CDC testing of Missouri&#8217;s bird flu case hits obstacles, delaying answers"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>U.S. health officials have run into obstacles in their efforts to determine whether a <a href=\"https:\/\/www.statnews.com\/2024\/09\/06\/missouri-h5-bird-flu-case-no-animal-contacts\/\">Missouri person infected with H5N1 bird flu<\/a> passed the virus on to others, causing a delay that will likely fuel concerns about the possibility that there has been human-to-human transmission.<\/p>\n<p>The Centers for Disease Control and Prevention has blood samples from <a href=\"https:\/\/www.statnews.com\/2024\/09\/27\/bird-flu-missouri-four-more-healthcare-workers\/\">several health workers<\/a> and a <a href=\"https:\/\/www.statnews.com\/2024\/09\/13\/h5n1-bird-flu-missouri-close-contact-cdc\/\">household contact<\/a> of the Missouri case that it plans to test for antibodies that would indicate whether they too had been infected with the virus, an agency official told STAT.<\/p>\n<p>But the CDC has had to develop a new test to look for those antibodies because key genetic changes to the main protein on the exterior of the virus found in the Missouri case meant the agency\u2019s existing tests might not have been reliable, Demetre Daskalakis, director of the CDC\u2019s National Center on Immunization and Respiratory Diseases, said in an interview. He suggested it will be mid-October before the work can be completed.<\/p>\n<p>\u201cThe antibodies that would grow in the person exposed to that virus would then be different then the antibodies that would grow in a person who had a virus without those mutations,\u201d Daskalakis said.<\/p>\n<p>Developing the new test has been challenging because the sample from the patient contained so little viral material that the CDC was not able to grow whole viruses from it. Instead its scientists have had to reverse engineer H5N1 viruses that contain the changes to use them as the basis for the new serology test, he said.<\/p>\n<p>There is still no explanation of how the individual contracted the virus. The unidentified individual was hospitalized for other health problems on Aug. 22, and was released three days later. While in hospital the person was tested for a panel of respiratory viruses and tested positive for influenza.\u00a0<\/p>\n<p>The state\u2019s ongoing investigation into the case has retrospectively turned up six health workers who cared for the patient who went on to experience respiratory symptoms. One tested negative for flu at the time she or he was ill but the other five were not tested when they were sick. Neither was the household contact. Blood from those six individuals will be tested for H5N1 antibodies.<\/p>\n<aside class=\"wp-block-stat-article-recirc-single\">\n<div class=\"recirc-single-image\" data-href=\"https:\/\/www.statnews.com\/2024\/10\/01\/niaid-jeanne-marrazzo-interview\/\">\n\t\t\t<img decoding=\"async\" width=\"768\" height=\"432\" src=\"https:\/\/www.statnews.com\/wp-content\/uploads\/2024\/09\/53413575457_8c9c105a3f_o-768x432.jpg\" class=\"attachment-article-main-medium-large size-article-main-medium-large wp-post-image\" alt=\"\" loading=\"lazy\" sizes=\"auto, (min-width: 540px) and (max-width: 767px) 288px, (min-width: 768px) and (max-width: 1023px) 257px, (min-width: 1024px) and (max-width: 1199px) 287px, (min-width: 1200px) 245px, 246px\" srcset=\"https:\/\/www.statnews.com\/wp-content\/uploads\/2024\/09\/53413575457_8c9c105a3f_o-768x432.jpg 768w, https:\/\/www.statnews.com\/wp-content\/uploads\/2024\/09\/53413575457_8c9c105a3f_o-1024x576.jpg 1024w, https:\/\/www.statnews.com\/wp-content\/uploads\/2024\/09\/53413575457_8c9c105a3f_o-2048x1152.jpg 2048w, https:\/\/www.statnews.com\/wp-content\/uploads\/2024\/09\/53413575457_8c9c105a3f_o-1600x900.jpg 1600w\"\/>\t\t<\/div>\n<h3 class=\"recirc-single-heading\">\n\t\t\t\t\t\t<a href=\"https:\/\/www.statnews.com\/2024\/10\/01\/niaid-jeanne-marrazzo-interview\/\" rel=\"\">Q&amp;A: NIAID\u2019s Jeanne Marrazzo speaks on bird flu, mpox, and succeeding Anthony Fauci<\/a><br \/>\n\t\t<\/h3>\n<\/aside>\n<p>There are fears in some quarters that this represents a cluster of cases, which infectious disease experts agree would be concerning. Although there have been a few times where person-to-person spread of the virus probably took place outside the U.S., in the main H5N1 is a virus that can\u2019t easily infect humans or spread from one person to another. Were that to change, the risk of a pandemic would be dramatically higher. That possibility has sparked an understandable desire for answers about the Missouri case, fast.\u00a0<\/p>\n<p>But that isn\u2019t possible in this case, Daskalakis said. \u201cBiology takes time,\u201d he said.\u00a0<\/p>\n<p>Jesse Bloom, an evolutionary virologist at the Fred Hutchinson Cancer Center in Seattle, recently commented on the mutations of the Missouri virus on the social media site X, noting that one is <a href=\"https:\/\/x.com\/jbloom_lab\/status\/1835175821520388304\" target=\"_blank\" rel=\"noopener\">sufficiently important<\/a> that it might erode the effectiveness of some of the candidate vaccine viruses that have been create to be the starting material for H5 vaccines, if mass production is needed.<\/p>\n<p>Bloom told STAT the mutation is not present in the candidate virus that was used to produce 4.8 million doses of vaccine that are currently held in the Department of Health and Human Services\u2019 National Pre-Pandemic Influenza Vaccine Stockpile.<\/p>\n<p>The mutation in the Missouri virus could also affect a serology test\u2019s ability to detect antibodies in blood samples, if the test did not look for antibodies that recognize it, Bloom said. The result could be a false negative test, or test results that are hard to read.<\/p>\n<p>\u201cIf you\u2019re getting serology that\u2019s kind of at this ambiguous level, where it\u2019s a little bit hard to be super confident whether it\u2019s positive or negative, certainly this type of mutation could make you want to then redo the assays with a virus that contained that mutation,\u201d Bloom said.\u00a0<\/p>\n<p>The CDC is also concerned about the possibility that antibodies to seasonal flu strains \u2014 which virtually every adult alive would have \u2014 could trigger a false positive result when the H5N1 serology test is run. So the agency\u2019s labs will also take the additional step of depleting each sample of antibodies to H1N1, one of the human flu strains, before it tests the Missouri blood samples for H5N1 antibodies, Daskalakis said.\u00a0<\/p>\n<p>All this work adds to the time it is taking to reach answers. But Bloom saw it as defensible, though he stressed he did not have details of the approaches the CDC is taking to test the Missouri samples.<\/p>\n<p>\u201cAs someone who\u2019s very interested, I hope they\u2019re able to do it as quickly as possible,\u201d he said. But he noted that in a case such as this, \u201cserology can be a little bit more tricky if you\u2019re trying to reach a really highly confident conclusion.\u201d<\/p>\n<p>\u201cI\u2019m sure they don\u2019t want to put out something prematurely that\u2019s inaccurate. So if they\u2019re not getting a super clear answer they may want to spend more time working on positive and negative controls and really making sure they\u2019re correct in terms of whatever they end up saying,\u201d Bloom said.<\/p>\n<p>Michael Osterholm, director of the University of Minnesota\u2019s Center for Infectious Diseases Research and Policy, also said he can understand the delay, though he expressed concern that some people have already concluded that transmission did occur in Missouri.<\/p>\n<p>While it is possible that serology testing will show some of the patient\u2019s contacts were infected, it\u2019s also possible that those individuals had Covid-19 or another respiratory bug, he said.\u00a0<\/p>\n<p>\u201cWe are all just going to have to wait and see,\u201d said Osterholm.<\/p>\n<p>Meanwhile the CDC continues to monitor multiple data streams for any evidence of unusual flu activity in Missouri, Daskalakis said. To date, there has been nothing that has triggered any alarms.<\/p>\n<p>\u201cWe\u2019re not seeing anything that looks like any flu signal,\u201d he said. \u201cAll of the systems are firing at full steam to make sure that we see [it] if there\u2019s anything going on.\u201d<\/p>\n<p><em>Correction: A previous version of this story incorrectly suggested the mutation in the Missouri patient\u2019s virus might have eroded the effectiveness of all H5 vaccines the U.S. government has stockpiled.<\/em><\/p>\n<\/div>\n<p><script>\n\t\t\t\twindow.statGlobal = window.statGlobal || { };\n\t\t\t\twindow.statGlobal.analytics = window.statGlobal.analytics || { };\n\t\t\t\twindow.statGlobal.analytics.fbq = function( eventName, parameters ) {\n\t\t\t\t\tjQuery.ajax( {\n\t\t\t\t\t\turl: '\/wp-json\/stat-analytics\/v1\/facebook-pixel',\n\t\t\t\t\t\ttype: 'POST',\n\t\t\t\t\t\tdata: {\n\t\t\t\t\t\t\tevent_name: !eventName ? null : eventName,\n\t\t\t\t\t\t\tparameters: !parameters ? {} : parameters,\n\t\t\t\t\t\t\tsource_url: window.location.href\n\t\t\t\t\t\t},\n\t\t\t\t\t\tsuccess: function( data, textStatus, jqXHR ) {\n\t\t\t\t\t\t\t\/\/console.log( data );\n\t\t\t\t\t\t},\n\t\t\t\t\t\terror: function ( jqXHR, textStatus, errorThrown ) {\n\t\t\t\t\t\t\t\/\/console.log( jqXHR );\n\t\t\t\t\t\t}\n\t\t\t\t\t} );\n\t\t\t\t};\n\t\t\t\tjQuery( window ).on( 'load', function() {\n\t\t\t\t\tif ( !window.bgmpGdpr || window.bgmpGdpr.isOptedOut() ) {\n\t\t\t\t\t\treturn;\n\t\t\t\t\t}\n\t\t\t\t\t!function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod?\n\t\t\t\t\tn.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n;\n\t\t\t\t\tn.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0;\n\t\t\t\t\tt.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window,\n\t\t\t\t\tdocument,'script','https:\/\/connect.facebook.net\/en_US\/fbevents.js');\n\t\t\t\t\tfbq( 'init', '436331036555416' );\n\t\t\t\t\tfbq( 'track', 'PageView' );\n\t\t\t\t\tdocument.addEventListener( 'stat-hubspot-signup-subscribed', () => {\n\t\t\t\t\t\t\/\/ Successful HubSpot newsletter signup AJAX form submission.\n\t\t\t\t\t\twindow.statGlobal.analytics.fbq( 'Lead' );\n\t\t\t\t\t} );\n\t\t\t\t\t\t\t} );\n\t\t\t<\/script><br \/>\n<br \/><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.statnews.com\/2024\/10\/02\/missouri-bird-flu-virus-transmission-concerns\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>U.S. health officials have run into obstacles in their efforts to determine whether a Missouri person infected with H5N1 bird flu passed the virus on to others, causing a delay &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=109972\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-109972","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/109972","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=109972"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/109972\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=109972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=109972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=109972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}