{"id":110112,"date":"2024-10-04T01:17:10","date_gmt":"2024-10-03T18:17:10","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=110112"},"modified":"2024-10-04T01:17:10","modified_gmt":"2024-10-03T18:17:10","slug":"popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=110112","title":{"rendered":"Popular gut probiotic completely craps out in randomized controlled trial"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Any striking marketing claims in companies&#8217; ads about the gut benefits of a popular probiotic may be full of, well, the same thing that has their target audience backed up.<\/p>\n<p>In a randomized controlled trial, the probiotic <em>Bifidobacterium animalis<\/em> subsp. <em>lactis<\/em>\u2014used in many probiotic products, including Dannon&#8217;s Activia yogurts\u2014did nothing to improve bowel health in people with constipation, according to <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2824333\">data from a randomized triple-blind placebo-controlled clinical trial<\/a> published Wednesday in JAMA Network Open.<\/p>\n<p>The study adds to a mixed and mostly unconvincing body of scientific literature on the bowel benefits of the bacterium, substrains of which are sometimes sold with faux scientific-sounding names in products. Dannon, for instance, previously marketed its substrain, DN-173 010, as &#8220;Bifidus regularis.&#8221;<\/p>\n<h2>Digested data<\/h2>\n<p>For the new study, researchers in China recruited 228 middle-aged adults, 85 percent of whom were women. The participants, all from Shanghai, were considered healthy based on medical testing and records, except for reporting <a href=\"https:\/\/www.justintimemedicine.com\/curriculum\/1913\">functional constipation<\/a>. This is a condition defined by having two or more signs of difficulty evacuating the bowels, such as frequent straining and having rock-like stool. For the study, the researchers included the additional criterion that participants have three or fewer complete, spontaneous bowel movements (CSBMs) per week.<\/p>\n<p>The participants were randomized to take either a placebo (117 participants) or the probiotic (112 participants) every day for eight weeks. Both groups got packets of sweetened powder that participants added to a glass of water taken before breakfast each morning. In addition to a sweetener, the daily probiotic packets contained freeze-dried <em>Bifidobacterium animalis<\/em> subsp. <em>lactis<\/em> substrain HN019, which is used in some commercial probiotic products. The first dose had a concentration of 7 \u00d7 10<sup>9<\/sup> colony-forming units (CFUs), then participants shifted to a daily dose of 4.69 \u00d7 10<sup>9<\/sup> CFUs. Many probiotic products have doses of <em>B. lactis<\/em> in ranges from 1 \u00d7 10<sup>9<\/sup> to 17 \u00d7 10<sup>9<\/sup>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/arstechnica.com\/health\/2024\/10\/popular-gut-probiotic-completely-craps-out-in-randomized-controlled-trial\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Any striking marketing claims in companies&#8217; ads about the gut benefits of a popular probiotic may be full of, well, the same thing that has their target audience backed up. &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=110112\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8630],"tags":[],"class_list":["post-110112","post","type-post","status-publish","format-standard","hentry","category-technology","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=110112"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110112\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=110112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=110112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=110112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}