{"id":110509,"date":"2024-10-05T02:08:57","date_gmt":"2024-10-04T19:08:57","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=110509"},"modified":"2024-10-05T02:08:57","modified_gmt":"2024-10-04T19:08:57","slug":"80-minute-sleep-loss-in-teens-exposed-to-forever-chemicals","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=110509","title":{"rendered":"80-Minute Sleep Loss in Teens Exposed to &#8220;Forever Chemicals&#8221;"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>igher blood levels of four specific types of per- and polyfluoroalkyl substances (PFAS), also known as \u201cforever chemicals,\u201d are linked to poorer sleep quality in young adults. These chemicals, found in everyday products and the environment, have been shown to disrupt genes responsible for regulating sleep and wake cycles, leading to decreased sleep duration and more sleep disturbances.<\/p>\n<p>PFAS exposure has long-term health implications, such as cognitive decline and increased risk of neurological diseases. The study highlights the need for stricter regulations on PFAS and further research into their impact on health.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>PFAS exposure is linked to poorer sleep quality, including less sleep and difficulty falling asleep.<\/li>\n<li>The study identifies specific genes affected by PFAS that regulate sleep hormones and cognitive functions.<\/li>\n<li>High levels of certain PFAS are associated with a reduction of about 80 minutes of sleep per night.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>USC<\/p>\n<p><strong>Research led by the\u00a0Keck School of Medicine of USC\u00a0has shown that levels of \u201cforever chemicals\u201d in the blood are linked with disruptions to a fundamental pillar of health \u2014 sleep.\u00a0<\/strong><\/p>\n<p>In the first study to examine that relationship in young adults, participants with higher levels of four specific types of per- and polyfluoroalkyl substances (PFAS) in their blood experienced worse sleep.<\/p>\n<p>The scientists are the first to delve into underlying molecular mechanisms, identifying genes involved with the body\u2019s natural defenses and a hormone that regulates sleep.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105088\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"799\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence.jpg\" alt=\"This shows a teen awake at night with a bottle of water in their hand.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/forever-chemicals-sleep-teens-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">High levels of the enzyme have been linked to cognitive decline in Alzheimer\u2019s \u2014 which has its own connections to sleep deficits. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>PFAS enter the body through contact with consumer items and are even ingested with food and water. They don\u2019t break down easily and can persist in the environment for decades. The vast majority of Americans have detectable levels of PFAS in their blood.\u00a0<\/p>\n<p>In recent years, forever chemicals have been associated with health harms from cancer and neurological disease to deficits in hormone and immune function.<\/p>\n<p>The study, supported by the National Institutes of Health (NIH) and published in the journal\u00a0<em>Environmental Advances<\/em>, is among a small body of research concerning PFAS and sleep.<\/p>\n<p>\u201cBecause the body needs sleep every day, if PFAS might be interfering with your sleep, that may affect you more immediately than other chronic health issues,\u201d said first and corresponding author Shiwen (Sherlock) Li, PhD, a postdoctoral researcher in the\u00a0Department of Population and Public Health Sciences\u00a0at the Keck School of Medicine.<\/p>\n<p>\u201cLong term, poor sleep has been connected to outcomes including neurological and behavioral problems, type 2 diabetes and Alzheimer\u2019s disease.\u201d<\/p>\n<p>In addition to providing insight into the biology of PFAS\u2019 influence on sleep, the study may add to evidence suggesting a rationale for closer regulation of forever chemicals.\u00a0<\/p>\n<p>\u201cSleep quality is an issue that affects almost everybody, so the impact of PFAS on sleep may have policy implications,\u201d said Li, who is advised by study co-authors Lida Chatzi, MD, PhD, director of the\u00a0USC Center for Translational Research on Environmental Health\u00a0and professor of population and public health sciences and of pediatrics, and Max Aung, PhD, MPH, associate director of community engagement for the center, and assistant professor of population and public health sciences.<\/p>\n<p><strong>Identifying forever chemicals potentially detrimental to good sleep<\/strong><\/p>\n<p>The researchers collected blood samples and information about sleep from 144 participants, age 19 to 24, who were part of the\u00a0USC Children\u2019s Health Study. Two sets of measurements were taken years apart, with about half of the participants contributing to both.\u00a0<\/p>\n<p>Out of seven types of PFAS examined, four were significantly associated with less sleep or worse quality of sleep \u2014 PFDA, PFHxS, PFOA and PFOS.<\/p>\n<p>For the first three of those, young adults with blood\u00a0levels in the highest one-third slept an average of about\u00a080 fewer minutes nightly than those in the lowest third. High combined levels of PFAS also correlated with shorter sleep.\u00a0<\/p>\n<p>For PFOS, high blood concentrations were significantly linked to self-reported problems falling asleep, staying asleep, waking up or feeling tired during waking hours.<\/p>\n<p>All four forever chemicals \u2014 some of which are associated with cancer and neurological disorders from ADHD to Alzheimer\u2019s disease \u2014 are considered \u201clegacy PFAS.\u201d Though widely used from the 1950s to the early 2000s, they have since been largely phased out in favor of similar compounds with unknown safety profiles.<\/p>\n<p>\u201cIt could be a matter of cumulative exposure over time,\u201d Li said. \u201cWhat we measured in the blood is likely driven by exposure since birth, or even prenatal exposures.\u201d<\/p>\n<p><strong>Biological clues emerge about PFAS and sleep disruptions<\/strong><\/p>\n<p>The team analyzed the four types of PFAS using toxicology databases that compile research connecting chemicals, diseases and changes in gene expression. Because no previous research drew together PFAS, sleep and gene expression, the team looked at the overlap between genes affected by the four forever chemicals and genes related to sleep disorders.\u00a0<\/p>\n<p>The investigators then profiled a panel of proteins \u2014 the products of the blueprints inscribed in genes \u2014 from participants\u2019 blood samples. Out of 600-plus candidate genes, seven activated by PFAS seemed to influence sleep.<\/p>\n<p>An important factor was an immune-oriented gene called\u00a0<em>HSD11B1<\/em>. It helps produce the hormone cortisol, which plays an important role in regulating the rhythm of sleep and wakefulness.<\/p>\n<p>\u201cIf the expression of the protein encoded by<em>\u00a0HSD11B1<\/em>\u00a0is disrupted, that means that cortisol levels could also be disrupted,\u201d Li said. \u201cThat, in turn, affects sleep.\u201d<\/p>\n<p>Another gene seemingly prominent in PFAS\u2019 impact on sleep,\u00a0<em>cathepsin B<\/em>, is related to cognitive function and memory. The resulting enzyme is a precursor of amyloid beta proteins, which are found in plaques in the brains of Alzheimer\u2019s patients. High levels of the enzyme have been linked to cognitive decline in Alzheimer\u2019s \u2014 which has its own connections to sleep deficits.<\/p>\n<p>The investigators will continue to explore forever chemicals and sleep patterns in children as part of the NIH\u2019s Multi-Omics for Health and Disease Consortium. They are also pursuing lab studies into the genes identified in the study and into associations between PFOS and brain development.<\/p>\n<p><strong>About this study<\/strong><\/p>\n<p>The study\u2019s other co-authors are Jesse Goodrich, Jiawen Carmen Chen, Elizabeth Costello, Emily Beglarian, Jiawen Liao, Brittney Baumert, Sarah Rock, Sandrah Eckel, Rob McConnell, Frank Gilliland, Zhanghua Chen and David Conti, all of the Department of Population and Public Health Sciences at the Keck School of Medicine of USC; Tanya Alderete of Johns Hopkins University; and Damaskini Valvi of the Icahn School of Medicine at Mount Sinai.<\/p>\n<p><strong>Funding: <\/strong>The study was supported by National Institute of Environmental Health Sciences (R01ES029944 along with more than two dozen other awards) and the\u00a0USC President\u2019s Sustainability Initiative Award.<\/p>\n<h2 class=\"wp-block-heading\">About this environmental neuroscience and neurodevelopment research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#1975786c6b7837757c7b7578777a59747c7d376c6a7a377c7d6c\" target=\"_blank\" rel=\"noreferrer noopener\">Laura LeBlanc<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/med.usc.edu\" target=\"_blank\" rel=\"noreferrer noopener\">USC<\/a><br \/><strong>Contact: <\/strong>Laura LeBlanc \u2013 USC<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/doi.org\/10.1016\/j.envadv.2024.100585\" target=\"_blank\" rel=\"noreferrer noopener\">Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins<\/a>\u201d by Shiwen (Sherlock) Li et al. <em>Environmental Advances<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins<\/strong><\/p>\n<h3 class=\"wp-block-heading\" id=\"cesectitle0003\">Background<\/h3>\n<p>Per-and polyfluoroalkyl substances (PFAS) contamination may disrupt sleep through disrupted metabolic and immune functions. The study aims to investigate the association and potential mechanism between PFAS and sleep.<\/p>\n<h3 class=\"wp-block-heading\" id=\"cesectitle0004\">Methods<\/h3>\n<p>We included 136 young adults recruited between 2014-2018 and 76 were re-assessed between 2020-2022. Additional 8 participants only had complete data between 2020-2022. Plasma PFAS (PFOS, PFOA, PFHxS, PFHpS, PFPeS, PFNA, PFDA) were measured at both visits using liquid-chromatography high-resolution mass spectrometry. Plasma proteins were measured by Olink\u00ae Explore 384 Cardiometabolic and Inflammation Panel I<strong>.<\/strong>\u00a0<\/p>\n<p>Sleep duration was self-reported at both visits along with follow-up sleep disturbance and sleep-related impairment using validated instruments. We utilized multiple linear regression to explore the association between individual PFAS (in tertile) and these sleep outcomes.<\/p>\n<p>PFAS associated with sleep outcomes were subjected to computational toxicology analysis using the Comparative Toxicogenomics Database and Toxicology in the 21st Century database to identify potential genetic links between them. Mediation analysis using proteomic data was then performed to confirm the findings from computational toxicology analysis.<\/p>\n<h3 class=\"wp-block-heading\" id=\"cesectitle0005\">Results<\/h3>\n<p>At baseline, one tertile increase in PFDA was associated with 0.39 (95 % CI: 0.05, 0.73) hours of shorter nightly sleep duration, and, at follow-up, PFHxS and PFOA were associated with 0.39 (95 % CI: 0.05, 0.72) and 0.32 (95 % CI: 0.01, 0.63) hours shorter sleep duration, respectively.<\/p>\n<p>One tertile increase in PFOS exposure was associated with a 2.99-point increase in sleep disturbance scores (95 % CI: 0.67, 5.31) and a 3.35-point increase in sleep-related impairment scores (95 % CI: 0.51, 6.20).<\/p>\n<p>Computational toxicology and mediation analyses identified potential mediating roles for several proteins in the PFAS-sleep associations, including 11-beta-dehydrogenase isozyme 1 (HSD11B1), cathepsin B (CTSB) and several immune system-related proteins.<\/p>\n<h3 class=\"wp-block-heading\" id=\"cesectitle0006\">Conclusion<\/h3>\n<p>Future large scale epidemiological and mechanistic studies should confirm our findings and test effect measure modification of the associations by age.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/sleep-teens-forever-chemicals-27781\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: igher blood levels of four specific types of per- and polyfluoroalkyl substances (PFAS), also known as \u201cforever chemicals,\u201d are linked to poorer sleep quality in young adults. These chemicals, &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=110509\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-110509","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110509","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=110509"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110509\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=110509"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=110509"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=110509"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}