{"id":110557,"date":"2024-10-05T05:13:09","date_gmt":"2024-10-04T22:13:09","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=110557"},"modified":"2024-10-05T05:13:09","modified_gmt":"2024-10-04T22:13:09","slug":"new-molecule-mimics-exercise-and-fasting-effects","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=110557","title":{"rendered":"New Molecule Mimics Exercise and Fasting Effects"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers have developed a molecule called LaKe that mimics the metabolic effects of strenuous exercise and fasting. This molecule increases lactate and ketone levels in the body, providing similar benefits to running 10 kilometers on an empty stomach, without physical exertion or dietary changes.<\/p>\n<p>Currently being tested in human trials, LaKe shows promise for helping people with limited physical ability maintain health, and may also aid in treating brain conditions like Parkinson\u2019s and dementia. The discovery offers a potential new path for those unable to follow strict exercise or fasting routines.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>The LaKe molecule mimics the effects of fasting and exercise by boosting lactate and ketones.<\/li>\n<li>Early research suggests it could help with conditions like brain trauma and dementia.<\/li>\n<li>Human trials are underway to test its use as a nutritional supplement for people unable to exercise.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Aarhus University<\/p>\n<p><strong>It is well known that regular exercise and periodic fasting have a series of positive effects on the body. Exercise and skipping meals makes for a stronger heart and reduces fat levels in the blood. <\/strong><\/p>\n<p>The explanation lies in the body\u2019s natural reaction in which increasing levels of lactate (the salt of lactic acid) and ketones act as efficient fuel for cells which benefit the body\u2019s organs.<\/p>\n<p>A group of chemistry, metabolism and diabetes researchers from Aarhus University has now created a molecule that can induce the same metabolic effects, without physical exertion or fasting.<\/p>\n<p>The study has just been published in the scientific journal:\u00a0<em>Journal of Agricultural and Food Chemistry<\/em>.<\/p>\n<p><strong>Same effect as a 10 km run on an empty stomach<\/strong><\/p>\n<p>\u201cWe\u2019ve developed a molecule that can mimic the body\u2019s natural metabolic response to strenuous exercise and fasting. In practice, the molecule brings the body into a metabolic state corresponding to running 10 kilometres at high speed on an empty stomach,\u201d explains Professor Thomas Poulsen from the Department of Chemistry at Aarhus University. He is one of the leading researchers behind the study.<\/p>\n<p>\u201cWhen lactate and ketone levels in the blood increase, the production of an appetite-suppressing hormone increases and the level of free fatty acids in the blood decreases. This has a number of health benefits, for example reducing the risk of developing metabolic syndrome.\u201d<\/p>\n<p>According to the professor, it is not possible to achieve the same effect through diet alone, since lactate and ketones, although they occur naturally, cannot be consumed in the necessary quantities without undesirable by-products such as acid and salt. This is where the new molecule, called LaKe, comes in.<\/p>\n<p><strong>Molecule &gt; dietary supplements<\/strong><\/p>\n<p>The development of LaKe is the result of several years of research collaboration between Thomas Poulsen, Professor Mogens Johannsen from the Department of Forensic Medicine, and Chief physician and Professor Niels M\u00f8ller, at the Department of Clinical Medicine and Steno Diabetes Center, Aarhus.<\/p>\n<p>All three have researched metabolism from different angles, and they all already knew from their own and others\u2019 studies that lactate and ketones have beneficial effects. It took them three years to make the chemical fusion of lactate and ketones, without the harmful \u2018fellow passengers\u2019 in the form of salt and acid.<\/p>\n<p>\u201cIn a way, we\u2019re not surprised by the effect, because we are combining well known substances. The innovation is that we have now created a molecule which allows us to artificially control the amounts of lactate and ketones safely,\u201d says Thomas Poulsen.<\/p>\n<p>So far, the molecule has only been tested on rats, but the first clinical trials in humans are now underway at Aarhus University Hospital.<\/p>\n<p>According to Thomas Poulsen, the trials are expected to pave the way for the molecule to become an advanced nutritional supplement. It will especially help people who cannot follow a strict exercise and diet plan.<\/p>\n<p>\u201cIt can be difficult to maintain motivation to run many kilometres at high speed and go without food. For people with physical ailments such as a weak heart or general weakness, a nutritional supplement can be the key to better recovery,\u201d explains Thomas Poulsen.<\/p>\n<p><strong>Perspectives for treatment of brain trauma<\/strong><\/p>\n<p>The molecule also has potential to alleviate concentration difficulties and may be used in the treatment of serious diseases such as Parkinson\u2019s and dementia. These diseases are often characterized by low energy levels in the brain, which inhibit its optimal functioning.<\/p>\n<p>\u201cBecause lactate can take over the role of glucose in the brain under stressful or traumatic conditions, there have been experiments to increase lactate levels in people with concussion.<\/p>\n<p>\u201cPatients who cannot perform strenuous exercise will benefit greatly from a drug that can boost these levels,\u201d explains Thomas Poulsen.<\/p>\n<h2 class=\"wp-block-heading\">About this neuropharmacology, diet, and exercise research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#0774736271696f68626d47667229636c\" target=\"_blank\" rel=\"noreferrer noopener\">Henriette Stevnhoej<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/au.dk\" target=\"_blank\" rel=\"noreferrer noopener\">Aarhus University<\/a><br \/><strong>Contact: <\/strong>Henriette Stevnhoej \u2013 Aarhus University<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jafc.4c04849\" target=\"_blank\" rel=\"noreferrer noopener\">Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate<\/a>\u201d by Thomas Poulsen et al. <em><em>Journal of Agricultural and Food Chemistry<\/em><\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate<\/strong><\/p>\n<p>Elevation of the plasma levels of (<em>S<\/em>)-lactate (Lac) and\/or (<em>R<\/em>)-beta-hydroxybutyrate (BHB) occurs naturally in response to strenuous exercise and prolonged fasting, respectively, resulting in millimolar concentrations of these two metabolites.<\/p>\n<p>It is increasingly appreciated that Lac and BHB have wide-ranging beneficial physiological effects, suggesting that novel nutritional solutions, compatible with high-level and\/or sustained consumption, which allow direct control of plasma levels of Lac and BHB, are of strong interest.<\/p>\n<p>In this study, we present a molecular hybrid between (<em>S<\/em>)-lactate and the BHB-precursor (<em>R<\/em>)-1,3-butanediol in the form of a simple ester referred to as\u00a0<strong><em>LaKe<\/em><\/strong>.<\/p>\n<p>We show that\u00a0<strong><em>LaKe<\/em><\/strong>\u00a0can be readily prepared on the kilogram scale and undergoes rapid hydrolytic conversion under a variety of physiological conditions to release its two constituents.<\/p>\n<p>Oral ingestion of\u00a0<strong><em>LaKe<\/em><\/strong>, in rats, resulted in dose-dependent elevation of plasma levels of Lac and BHB triggering expected physiological responses such as reduced lipolysis and elevation of the appetite-suppressing compound\u00a0<em>N<\/em>-L-lactoyl-phenylalanine (Lac-Phe).<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/lake-exercise-fasting-molecule-27785\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers have developed a molecule called LaKe that mimics the metabolic effects of strenuous exercise and fasting. This molecule increases lactate and ketone levels in the body, providing similar &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=110557\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-110557","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=110557"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110557\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=110557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=110557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=110557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}