{"id":110880,"date":"2024-10-06T01:32:56","date_gmt":"2024-10-05T18:32:56","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=110880"},"modified":"2024-10-06T01:32:56","modified_gmt":"2024-10-05T18:32:56","slug":"gene-activity-in-depression-linked-to-immune-system-and-inflammation","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=110880","title":{"rendered":"Gene Activity in Depression Linked to Immune System and Inflammation"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>A new study reveals that inflammation and immune system activation are closely linked to major depressive disorder (MDD), particularly in those resistant to standard antidepressants. Researchers analyzed gene expression in people with depression, finding increased immune-related gene activity, especially in those with higher inflammation.<\/p>\n<p>These findings suggest that targeting the immune system may be a potential treatment for those who don\u2019t respond to traditional antidepressants. The study emphasizes the need for personalized medicine approaches in treating depression, based on individual biological differences.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ol class=\"wp-block-list\">\n<li>About 1 in 3 people with depression have high levels of inflammation.<\/li>\n<li>Immune-related genes are more active in individuals with inflammation and depression.<\/li>\n<li>Targeting inflammation could help patients who don\u2019t respond to standard antidepressants.<\/li>\n<\/ol>\n<p><strong>Source: <\/strong>King\u2019s College London<\/p>\n<p><strong>A new study, conducted in a shared effort between U.K. and Italian researchers offers novel insights about the biological mechanisms behind major depressive disorder (MDD), and especially on the role of the immune system.<\/strong><\/p>\n<p>The study specifically analyzed \u201cgene expression,\u201d the process by which the instructions that are held in our genes are expressed, influencing bodily functions.<\/p>\n<p>The work is\u00a0published\u00a0in the journal\u00a0<em>Molecular Psychiatry<\/em>.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105117\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"799\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence.jpg\" alt=\"This shows a depressed woman.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/genetics-depression-immune-system-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The study found that individuals with depression who had increased levels of inflammation showed increased activity of genes linked with the immune system and with metabolic activity. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>Approximately 1 in 3 people with depression have high levels of inflammation, an activation of the\u00a0immune system, our body\u2019s defense against potentially harmful stimuli, such as infections.<\/p>\n<p>During stress, inflammation is activated to effectively fight threats, and it is likely the reason that the immune system is activated in depression, which is a condition of chronic stress.<\/p>\n<p>Individuals with depression and inflammation present a greater risk of not responding to standard antidepressants, and they might benefit from additional treatments targeting the immune system, such as anti-inflammatories.<\/p>\n<p>Thus, understanding the biological mechanisms underpinning this increased inflammation could also shed light on ways to help people with depression, especially those who do not respond to standard antidepressants.<\/p>\n<p>\u201cIn depression, as in almost every medical condition, one size does not fit all. Understanding the diversity of people with depression means also recognizing the different biological patterns in action. As the field of precision medicine advances, psychiatry must keep pace,\u201d says Dr. Luca Sforzini, King\u2019s IoPPN.<\/p>\n<p>Researchers used a technology called \u201cmRNA sequencing\u201d to measure the activity of all the genes expressed in the blood. The study found that individuals with depression who had increased levels of inflammation showed increased activity of genes linked with the immune system and with metabolic activity.<\/p>\n<p>The study found that even with moderately increased inflammation, there is a significant activation of immune-related genes. People with depression and very high levels of increased\u00a0inflammation\u00a0have additional activation of genes involved in\u00a0metabolic processes, that is, related to how we produce, consume and store energy, relevant, for example, to fat and sugar functions in the body.<\/p>\n<p>\u201cWith gene expression, we might capture something different from what is clinically observable, something \u2018intermediate\u2019 between what\u2019s encoded in our genes and what is ultimately manifested. Such research might therefore help to fully understand the biology of depression,\u201d says Professor Annamaria Cattaneo.<\/p>\n<p>In the study, the researchers also identified a specific gene expression profile in individuals who had effectively responded to an antidepressant, with changes in\u00a0biological mechanisms\u00a0relevant not only to inhibition of the immune function but also to the protection of the brain, suggesting that these biological processes may play a role in these people\u2019s recovery from depression and in the way antidepressants work.<\/p>\n<p>Overall, the present study demonstrates the importance of gene expression in understanding the biology of depression and of antidepressant actions.<\/p>\n<p>Our genes and their associated biological patterns might explain the differences between different types of depression, such as those who do or do not respond to standard antidepressants, or those who do or do not develop medical comorbidities like diabetes and cardiovascular problems.<\/p>\n<p>\u201cOur research highlights the need to understand the biological basis of different types of\u00a0depression, shifting away from the traditional approach, towards more targeted and personalized approaches,\u201d says Professor Carmine Pariante.<\/p>\n<h2 class=\"wp-block-heading\">About this genetics and depression research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/www.kcl.ac.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">Luca Sforzini<\/a><br \/><strong>Source: <\/strong><a href=\"http:\/\/www.kcl.ac.uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">King\u2019s College London<\/a><br \/><strong>Contact: <\/strong>Luca Sforzini \u2013 King\u2019s College London<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02736-w\" target=\"_blank\" rel=\"noreferrer noopener\">Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation<\/a>\u201d by Luca Sforzini et al. <em>Molecular Psychiatry<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation<\/strong><\/p>\n<p>Transcriptomic profiles are important indicators for molecular mechanisms and pathways involved in major depressive disorder (MDD) and its different phenotypes, such as immunometabolic depression.<\/p>\n<p>We performed whole-transcriptome and pathway analyses on 139 individuals from the observational, case-control, BIOmarkers in DEPression (BIODEP) study, 105 with MDD and 34 controls.<\/p>\n<p>We divided MDD participants based on levels of inflammation, as measured by serum high-sensitivity C-reactive protein (CRP), in\u00a0<em>n<\/em>\u2009=\u200939 \u2018not inflamed\u2019 (CRP\u2009&lt;\u20091\u2009mg\/L),\u00a0<em>n<\/em>\u2009=\u200931 with \u2018elevated CRP\u2019 (1\u20133\u2009mg\/L), and\u00a0<em>n<\/em>\u2009=\u200935 with \u2018low-grade inflammation\u2019 (&gt;3\u2009mg\/L).<\/p>\n<p>We performed whole-blood RNA sequencing using Illumina NextSeq 550 and statistical analyses with the Deseq2 package for R statistics (RUV-corrected) and subsequent pathway analyses with Ingenuity Pathway Analysis. Immunometabolic pathways were activated in individuals with CRP\u2009&gt;\u20091\u2009mg\/L, although surprisingly the CRP 1\u20133 group showed stronger immune activation than the CRP\u2009&gt;\u20093 group.<\/p>\n<p>The main pathways identified in the comparison between CRP\u2009&lt;\u20091 group and controls were cell-cycle-related, which may be protective against immunometabolic abnormalities in this \u2018non-inflamed\u2019 depressed group.<\/p>\n<p>We further divided MDD participants based on exposure and response to antidepressants (<em>n<\/em>\u2009=\u200947 non-responders,\u00a0<em>n<\/em>\u2009=\u200937 responders, and\u00a0<em>n<\/em>\u2009=\u200922 unmedicated), and identified specific immunomodulatory and neuroprotective pathways in responders (especially vs. non-responders), which could be relevant to treatment response.<\/p>\n<p>In further subgroup analyses, we found that the specific transcriptional profile of responders is independent of CRP levels, and that the inhibition of cell-cycle-related pathways in MDD with CRP\u2009&lt;\u20091\u2009mg\/L is present only in those who are currently depressed, and not in the responders.<\/p>\n<p>The present study demonstrates immunometabolic and cell-cycle-related transcriptomic pathways associated with MDD and different (CRP-based and treatment-based) MDD phenotypes, while shedding light on potential molecular mechanisms that could prevent or facilitate an individual\u2019s trajectory toward immunometabolic depression and\/or treatment-non-responsive depression.<\/p>\n<p>The recognition and integration of these mechanisms will facilitate a precision-medicine approach in MDD.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/genetics-depression-inflammation-27788\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A new study reveals that inflammation and immune system activation are closely linked to major depressive disorder (MDD), particularly in those resistant to standard antidepressants. Researchers analyzed gene expression &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=110880\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-110880","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=110880"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/110880\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=110880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=110880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=110880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}