{"id":110960,"date":"2024-10-06T06:36:57","date_gmt":"2024-10-05T23:36:57","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=110960"},"modified":"2024-10-06T06:36:57","modified_gmt":"2024-10-05T23:36:57","slug":"new-molecule-offers-hope-for-parkinsons-by-outperforming-l-dopa","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=110960","title":{"rendered":"New Molecule Offers Hope for Parkinson&#8217;s by Outperforming L-Dopa"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>A new study has discovered that ophthalmic acid, a molecule in the brain, acts like a neurotransmitter to regulate motor function, similar to dopamine. In Parkinson\u2019s mouse models, this molecule improved movement for over 20 hours\u2014far longer than the effects of the current treatment, L-dopa.<\/p>\n<p>This finding challenges the long-held belief that dopamine is the only key player in motor control. Researchers are now exploring how to use ophthalmic acid as a potential treatment for movement disorders, offering hope for more effective therapies.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ol class=\"wp-block-list\">\n<li>Ophthalmic acid acts like a neurotransmitter to control motor function.<\/li>\n<li>It improved movement for over 20 hours in Parkinson\u2019s mouse models.<\/li>\n<li>This discovery opens up new possibilities for treating movement disorders like Parkinson\u2019s.<\/li>\n<\/ol>\n<p><strong>Source: <\/strong>UC Irvine<\/p>\n<p><strong>A research team from the University of California, Irvine is the first to reveal that a molecule in the brain \u2013 ophthalmic acid \u2013 unexpectedly acts like a neurotransmitter similar to dopamine in regulating motor function, offering a new therapeutic target for Parkinson\u2019s and other movement diseases.<\/strong><\/p>\n<p>In the study, published in the October issue of the journal\u00a0<em>Brain<\/em>, researchers observed that ophthalmic acid binds to and activates calcium-sensing receptors in the brain, reversing the movement impairments of Parkinson\u2019s mouse models for more than 20 hours.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105121\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience.jpg\" alt=\"The shows neurons.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/molecule-parkinsons-ldopa-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">In the study, published in the October issue of the journal Brain, researchers observed that ophthalmic acid binds to and activates calcium-sensing receptors in the brain, reversing the movement impairments of Parkinson\u2019s mouse models for more than 20 hours. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The disabling neurogenerative disease affects millions of people worldwide over the age of 50. Symptoms, which include tremors, shaking and lack of movement, are caused by decreasing levels of dopamine in the brain as those neurons die. L-dopa, the front-line drug for treatment, acts by replacing the lost dopamine and has a duration of two to three hours.<\/p>\n<p>While initially successful, the effect of L-dopa fades over time, and its long-term use leads to dyskinesia \u2013 involuntary, erratic muscle movements in the patient\u2019s face, arms, legs and torso.<\/p>\n<p>\u201cOur findings present a groundbreaking discovery that possibly opens a new door in neuroscience by challenging the more-than-60-year-old view that dopamine is the exclusive neurotransmitter in motor function control,\u201d said co-corresponding author Amal Alachkar, School of Pharmacy &amp; Pharmaceutical Sciences professor.<\/p>\n<p>\u201cRemarkably, ophthalmic acid not only enabled movement, but also far surpassed L-dopa in sustaining positive effects. The identification of the ophthalmic acid-calcium-sensing receptor pathway, a previously unrecognized system, opens up promising new avenues for movement disorder research and therapeutic interventions, especially for Parkinson\u2019s disease patients.\u201d<\/p>\n<p>Alachkar began her investigation into the complexities of motor function beyond the confines of dopamine more than two decades ago, when she observed robust motor activity in Parkinson\u2019s mouse models without dopamine.<\/p>\n<p>In this study, the team conducted comprehensive metabolic examinations of hundreds of brain molecules to identify which are associated with motor activity in the absence of dopamine. After thorough behavioral, biochemical and pharmacological analyses, ophthalmic acid was confirmed as an alternative neurotransmitter.<\/p>\n<p>\u201cOne of the critical hurdles in Parkinson\u2019s treatment is the inability of neurotransmitters to cross the blood-brain barrier, which is why L-DOPA is administered to patients to be converted to dopamine in the brain,\u201d Alachkar said.<\/p>\n<p>\u201cWe are now developing products that either release ophthalmic acid in the brain or enhance the brain\u2019s ability to synthesize it as we continue to explore the full neurological function of this molecule.\u201d<\/p>\n<p>Team members also included doctoral student and lab assistant Sammy Alhassen, who is now a postdoctoral scholar at UCLA; lab specialist Derk Hogenkamp; project scientist Hung Anh Nguyen; doctoral student Saeed Al Masri; and co-corresponding author Olivier Civelli, the Eric L. and Lila D. Nelson Chair in Neuropharmacology \u2013 all from the School of Pharmacy &amp; Pharmaceutical Sciences \u2013 as well as Geoffrey Abbott, professor of physiology &amp; biophysics and vice dean of basic science research in the School of Medicine.<\/p>\n<p><strong>Funding: <\/strong>The study was supported by a grant from the National Institute of Neurological Disorders and Stroke under award number NS107671 and the Eric L. and Lila D. Nelson Chair in Neuropharmacology.<\/p>\n<p>Alachkar and Civelli are inventors on a provisional patent that covers products related to ophthalmate and calcium-sensing receptors in motor function.<\/p>\n<h2 class=\"wp-block-heading\">About this neuropharmacology and Parkinson\u2019s disease research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#99e9f1f8ebebf0f4f8d9ecfaf0b7fcfdec\" target=\"_blank\" rel=\"noreferrer noopener\">Patricia Harriman<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/uci.edu\" target=\"_blank\" rel=\"noreferrer noopener\">UC Irvine<\/a><br \/><strong>Contact: <\/strong>Patricia Harriman \u2013 UC Irvine<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Closed access.<br \/>\u201c<a href=\"https:\/\/academic.oup.com\/brain\/article-abstract\/147\/10\/3379\/7636309\" target=\"_blank\" rel=\"noreferrer noopener\">Ophthalmate is a new regulator of motor functions via CaSR: implications for movement disorders<\/a>\u201d by Amal Alachkar et al. <em>Brain<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Ophthalmate is a new regulator of motor functions via CaSR: implications for movement disorders<\/strong><\/p>\n<p>Dopamine\u2019s role as the principal neurotransmitter in motor functions has long been accepted. We broaden this conventional perspective by demonstrating the involvement of non-dopaminergic mechanisms.<\/p>\n<p>In mouse models of Parkinson\u2019s disease, we observed that\u00a0L-DOPA elicited a substantial motor response even when its conversion to dopamine was blocked by inhibiting the enzyme aromatic amino acid decarboxylase (AADC).<\/p>\n<p>Remarkably, the motor activity response to\u00a0L-DOPA in the presence of an AADC inhibitor (NSD1015) showed a delayed onset, yet greater intensity and longer duration, peaking at 7 h, compared to when\u00a0L-DOPA was administered alone.<\/p>\n<p>This suggests an alternative pathway or mechanism, independent of dopamine signalling, mediating the motor functions.<\/p>\n<p>We sought to determine the metabolites associated with the pronounced hyperactivity observed, using comprehensive metabolomics analysis.<\/p>\n<p>Our results revealed that the peak in motor activity induced by NSD1015\/L-DOPA in Parkinson\u2019s disease mice is associated with a surge (20-fold) in brain levels of the tripeptide ophthalmic acid (also known as ophthalmate in its anionic form).<\/p>\n<p>Interestingly, we found that administering ophthalmate directly to the brain rescued motor deficits in Parkinson\u2019s disease mice in a dose-dependent manner.<\/p>\n<p>We investigated the molecular mechanisms underlying ophthalmate\u2019s action and discovered, through radioligand binding and cAMP-luminescence assays, that ophthalmate binds to and activates the calcium-sensing receptor (CaSR).<\/p>\n<p>Additionally, our findings demonstrated that a CaSR antagonist inhibits the motor-enhancing effects of ophthalmate, further solidifying the evidence that ophthalmate modulates motor functions through the activation of the CaSR.<\/p>\n<p>The discovery of ophthalmate as a novel regulator of motor function presents significant potential to transform our understanding of brain mechanisms of movement control and the therapeutic management of related disorders.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/parkinsons-ophthalmic-acid-27789\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A new study has discovered that ophthalmic acid, a molecule in the brain, acts like a neurotransmitter to regulate motor function, similar to dopamine. 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