{"id":112749,"date":"2024-10-11T02:38:47","date_gmt":"2024-10-10T19:38:47","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=112749"},"modified":"2024-10-11T02:38:47","modified_gmt":"2024-10-10T19:38:47","slug":"are-nasal-vaccines-the-key-to-ending-covid-19","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=112749","title":{"rendered":"Are nasal vaccines the key to ending COVID-19?"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div id=\"\">\n<header aria-label=\"Beginning of Article\" class=\"article-header article-header--story\">\n<nav aria-label=\"Breadcrumb\" class=\"breadcrumbs\" data-aqa=\"nav-breadcrumb\">\n<p>Breadcrumb Trail Links<\/p>\n<ol class=\"breadcrumbs__items list-unstyled\">\n<li class=\"breadcrumbs__item\"><a class=\"breadcrumbs__item-link\" data-tb-category-link=\"\" href=\"http:\/\/ottawacitizen.com\/category\/news\/local-news\/\">Local News<\/a><\/li>\n<\/ol>\n<\/nav>\n<div class=\"article-header__detail\">\n<div class=\"article-header__detail__texts\">\n<p class=\"article-subtitle\">Existing COVID-19 vaccines can prevent severe disease, but not infection. A new hope comes in the form of needle-free mucosal vaccines.<\/p>\n<div class=\"callout callout--noindent flex-align-center flex-justify-between\" data-evt-val=\"{\" control_fields=\"\" data-evt=\"visible\" data-evt-typ=\"element_view\"><span class=\"callout__text\"> Get the latest from Elizabeth Payne straight to your inbox <\/span><button class=\"button button--icon button--primary-alt\" data-id-login-redirect=\"https:\/\/ottawacitizen.com\/author\/epayne58\/newsletters\/\" type=\"button\"><span class=\"button__text\">Sign Up<\/span> <span aria-hidden=\"true\" class=\"button__icon\"> <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 11 11\" width=\"11\"><polygon points=\"1.1 0 7 6 1.1 12 0 10.9 4.8 6 0 1.1\"\/><\/svg> <\/span><\/button><\/div>\n<div class=\"article-meta\">\n<p><span class=\"published-date__since\">Published Oct 10, 2024<\/span> \u00a0\u2022\u00a0 <span class=\"updated-date__since\">Last updated 1\u00a0hour ago<\/span> \u00a0\u2022\u00a0 <span class=\"published-date__word-count\">7 minute read<\/span><\/p>\n<div class=\"article-meta__bottom\"><a aria-label=\"Join the conversation\" class=\"article-meta-comment-count\" data-story-comment-component=\"\" href=\"#comments-area\">   <\/a><\/p>\n<div class=\"bookmark-wrapper\">\n<div class=\"popover\" data-aqa=\"popover\" data-click-to-appear=\"True\" data-container=\"\" data-container-offset=\"\" data-no-style=\"\" data-popover-component=\"\" data-position=\"top\" data-sticky=\"\" data-tail-offset=\"200\" data-tail-position=\"right\"><button class=\"popover__trigger bookmark-button\"><span class=\"save-article-button save-article-button--default\" title=\"Save article\" data-article-id=\"880211ca-1e53-49cd-bd36-c681a3a7d563\" data-evt-skip-click=\"true\"\/><\/button><\/p>\n<div aria-describedby=\"popover-desc-popover-bookmark\" class=\"popover__content\" hidden=\"\" role=\"dialog\">\n<div class=\"popover__content__wrapper\">\n<div class=\"popover__content__text\" id=\"popover-desc-popover-bookmark\">\n<div class=\"bookmark__popover__content\">\n<p>You can save this article by registering for free <a class=\"bookmark-link\" data-evt-skip-click=\"true\" href=\"http:\/\/ottawacitizen.com\/register\/\">here<\/a>. Or <a class=\"bookmark-link\" data-evt-skip-click=\"true\" href=\"http:\/\/ottawacitizen.com\/sign-in\/\">sign-in<\/a> if you have an account.<\/p>\n<\/div>\n<\/div>\n<p><button class=\"popover__content__close\" data-evt-skip-click=\"true\" title=\"Close\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" viewbox=\"0 0 12 12\" class=\"icon--close\" height=\"12\" version=\"1.1\" width=\"12\"><polygon points=\"12 0.95 11.05 0 6 5.05 0.95 0 0 0.95 5.05 6 0 11.05 0.95 12 6 6.95 11.05 12 12 11.05 6.95 6\"\/><\/svg><\/button><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<figure class=\"featured-image\" data-aqa=\"featured-image\"><picture class=\"featured-image__ratio\"><source media=\"(min-width: 1200px)\" srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=564&amp;h=423&amp;type=webp&amp;sig=HCNztGt1sPUf2hmo1gZBBQ,&#10;            https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=1128&amp;h=846&amp;type=webp&amp;sig=10C3Js5GeaK4D__aWaCajg 2x\" type=\"image\/webp\"><source media=\"(min-width: 1200px)\" srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=564&amp;h=423&amp;type=jpg&amp;sig=-ygiPsBAbvhP--KGuKmDVw,&#10;                https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=1128&amp;h=846&amp;type=jpg&amp;sig=_ntkwlqVx6wHsqLAfhFJzw 2x\" type=\"image\/jpeg\"><source media=\"(min-width: 768px)\" srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=472&amp;h=354&amp;type=webp&amp;sig=yTK4M0OAyhYtV1hC7hA-mg,&#10;            https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=944&amp;h=708&amp;type=webp&amp;sig=N19Yi7915wHTwQo0_hQYaA 2x\" type=\"image\/webp\"><source media=\"(min-width: 768px)\" srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=472&amp;h=354&amp;type=jpg&amp;sig=6w5zQ6uyKDRpnaXhDNJ8-g,&#10;                https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=944&amp;h=708&amp;type=jpg&amp;sig=_ppzdFXUO8r-4tHs9beMRw 2x\" type=\"image\/jpeg\"><source media=\"(max-width: 767px)\" srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=288&amp;h=216&amp;type=webp&amp;sig=YH7omJb_jyj1xyavygWpKw,&#10;            https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=576&amp;h=432&amp;type=webp&amp;sig=8c_EG1P3QGeBoTedqdeMVQ 2x\" type=\"image\/webp\"><img loading=\"lazy\" decoding=\"async\" alt=\"demonstrating McMaster's new inhaled COVID-19 vaccine\" class=\"featured-image__image type:primaryImage\" src=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=288&amp;h=216&amp;sig=ElhbgSeh-okZeJ_sH9tu-g\" srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=288&amp;h=216&amp;sig=ElhbgSeh-okZeJ_sH9tu-g,&#10;                    https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/nebulizer-matt-miller-labs-00981_jpg.jpg?quality=90&amp;strip=all&amp;w=576&amp;h=432&amp;sig=_ey9HHmxT9Gq0-A-tdh3vw 2x\" height=\"750\" width=\"1000\"\/><\/source><\/source><\/source><\/source><\/source><\/picture><figcaption class=\"featured-image__caption image-caption\"><span class=\"caption\">Matthew Miller, with trainee Hannah Stacey, demonstrating McMaster&#8217;s new inhaled COVID-19 vaccine. The vaccine is entering Phase 2 human trials this winter.<\/span> <span class=\"credit\">Photo by Supplied photo<\/span> \/<span class=\"distributor\">.<\/span><\/figcaption><\/figure>\n<\/div>\n<\/header>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<h2 class=\"visually-hidden\">Article content<\/h2>\n<p>When the first COVID-19 vaccines began to roll out in late 2020, they were met with gratitude and hope. To many people, the remarkable production of vaccines less than a year into the deadly global pandemic suggested the end would soon be in sight.<\/p>\n<p>But it wasn\u2019t. Nearly five years later, the global emergency around COVID-19 has ended as have many the public health measures along with the public\u2019s focus, but the pandemic continues. In recent weeks, a wave of infections \u2014 driven by newer, highly contagious variants \u2014 has spread across Canada and the early fall surge of COVID-19 continues.<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_2\">\n<section aria-describedby=\"advertisment4710631152645200164215421895966720\" class=\"ad\">\n<p>Advertisement 2<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-2\">\n<div class=\"ad__inner__container\" data-ad=\"[[6,6],[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-interscroller=\"6x6\" data-ad-loc=\"2\" data-ad-mobile=\"[[6,6],[320,50],[300,50],[300,250],[300,600]]\" data-aqa=\"advertisement\" id=\"ad-2\" style=\"--desktopHeight:250px;--mobileHeight:600px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<div class=\"article-block article-block-bg article-content__sign-in-group hidden\" data-aqa=\"identity-sign-in\" data-async=\"\" id=\"article-block\">\n<section class=\"row\">\n<header class=\"identity-intro col-xs-12 col-md-6 flex-justify-center\">\n<div class=\"col-xs-12 col-sm-10 col-md-10\"><img decoding=\"async\" alt=\"Ottawa Citizen\" class=\"market-logo\" height=\"37\" loading=\"lazy\" src=\"https:\/\/dcs-static.gprod.postmedia.digital\/17.1.1\/websites\/images\/identity\/logo-identity-oc-new.svg\" width=\"280\"\/><\/p>\n<div class=\"intro-body__premium hidden\">\n<p>THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLY<\/p>\n<p class=\"identity-intro__description\">Subscribe now to read the latest news in your city and across Canada.<\/p>\n<ul class=\"list-unstyled list-checkmark\">\n<li>Exclusive articles from Elizabeth Payne, David Pugliese, Andrew Duffy, Bruce Deachman and others. 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Plus, food reviews and event listings in the weekly newsletter, Ottawa, Out of Office.<\/li>\n<li>Unlimited online access to Ottawa Citizen and 15 news sites with one account.<\/li>\n<li>Ottawa Citizen ePaper, an electronic replica of the print edition to view on any device, share and comment on.<\/li>\n<li>Daily puzzles, including the New York Times Crossword.<\/li>\n<li>Support local journalism.<\/li>\n<\/ul>\n<\/div>\n<div class=\"intro-body__anonymous\">\n<p>REGISTER \/ SIGN IN TO UNLOCK MORE ARTICLES<\/p>\n<p class=\"identity-intro__description\">Create an account or sign in to continue with your reading experience.<\/p>\n<ul class=\"list-unstyled list-checkmark\">\n<li>Access articles from across Canada with one account.<\/li>\n<li>Share your thoughts and join the conversation in the comments.<\/li>\n<li>Enjoy additional articles per month.<\/li>\n<li>Get email updates from your favourite authors.<\/li>\n<\/ul>\n<\/div>\n<div class=\"intro-body__registration_only hidden\">\n<p>THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK.<\/p>\n<p class=\"identity-intro__description\">Create an account or sign in to continue with your reading experience.<\/p>\n<ul class=\"list-unstyled list-checkmark\">\n<li>Access articles from across Canada with one account<\/li>\n<li>Share your thoughts and join the conversation in the comments<\/li>\n<li>Enjoy additional articles per month<\/li>\n<li>Get email updates from your favourite authors<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/header>\n<div class=\"identity-screen m-x-0 p-x-0 col-xs-12 col-md-6 flex-justify-center flex-align-center\" aria-live=\"assertive\">\n<section class=\"sail\" data-account-id=\"b9d3df2fccd108b5eff3c44f573b2cd6\" data-sailthru-personalization-engine=\"\" data-sailthru-personalization-engine-component=\"\"\/>\n<div class=\"m-x-0 p-x-0 col-xs-12 col-sm-6 col-md-12 flex-align-justify-center\" data-auth-component=\"\" id=\"auth-screen-form\">\n<div class=\"identity-screen-form--active w-full flex-align-justify-center\">\n<div class=\"identity-screen-form identity-screen__content w-full\">\n<h2 class=\"blocker-title\">Sign In or Create an Account<\/h2>\n<p><span class=\"identity-divider__line\"\/><span class=\"identity-divider__text\">or<\/span><span class=\"identity-divider__line\"\/><\/p>\n<\/div>\n<\/div>\n<\/div>\n<footer class=\"identity-footer identity-screen__content m-x-0 p-x-0 col-sm-6 col-md-12\"\/><\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>Updated mRNA-based COVID-19 vaccines that are a better match for the latest variants are being rolled out, the latest in a series of vaccines that have reduced the most severe acute effects of the virus for many, as well as death rates and hospitalizations.<\/p>\n<p>It is a remarkable achievement that saved lives, but it has not been able to stop the virus from spreading. COVID-19 remains a leading cause of death in Canada. And, as health experts understand more about the long-term damage that can result from the virus, including Long COVID, heart disease, stroke, and dementia, among others, COVID-19 has continued to surprise even those who study it closest.<\/p>\n<p>\u201cI think anybody who tells you COVID-19 isn\u2019t a surprise is not being truthful,\u201d said Matthew Miller, who is co-director of the Canadian Pandemic Preparedness Hub, Canada Research Chair in Viral Pandemics and an associate professor in biochemistry at McMaster University in Hamilton. He is part of the research team that is developing an inhaled COVID-19 vaccine.<\/p>\n<p>\u201cI have studied pandemic viruses for a long time. I completely expected we would be in a place by now where COVID-19 was exhibiting seasonal trends (similar to influenza and other seasonal viruses that generally occur in the fall and winter). Clearly I was wrong.<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_3\">\n<section aria-describedby=\"advertisment7212287358435987350284914476974080\" class=\"ad\">\n<p>Advertisement 3<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-3\">\n<div class=\"ad__inner__container\" data-ad=\"[[7,7],[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-interscroller=\"7x7\" data-ad-loc=\"3\" data-ad-mobile=\"[[7,7],[300,250],[320,50],[300,50]]\" data-aqa=\"advertisement\" id=\"ad-3\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>\u201cI don\u2019t think there are many people who in good faith can say that when this was taking off they thought we might still be in the place we are now.\u201d<\/p>\n<p>But amid fatigue, there is a new hope that the end \u2014 at least to the pandemic as we know it \u2014 might eventually be in sight.<\/p>\n<p>That hope comes in the form of mucosal vaccines \u2014 next-generation vaccines that are needle-free and can be sprayed or inhaled. Some see mucosal vaccines as the best hope to end the COVID-19 pandemic. They are now in development in labs around the world, including in Canada. The United States and other countries are investing heavily in the development of mucosal vaccines for COVID-19 and beyond.<\/p>\n<p>Much of the excitement around mucosal vaccines is focused on their potential to stop infections before they take hold by creating a protective immune barrier in the respiratory tract and mucosal system, the entry point for infections<strong>. <\/strong>Existing COVID-19 vaccines can prevent severe disease, but not infection.<\/p>\n<p>The team Miller is part of at McMaster is about to begin Phase 2 trials on a COVID-19 vaccine that is inhaled using a device similar to an asthma inhaler. It is the most promising mucosal COVID-19 vaccine under development in Canada and is expected to be tested in Canadian cities, including Ottawa, next year. The platform used for the COVID-19 vaccine can be used against other illnesses as well.<\/p>\n<\/section>\n<div class=\"js-widget-content article-content__widget-group article-content__widget-group--content-slot25 article-content__widget-group--newsletter-slot\">\n<section class=\"newsletter-widget__new-story-page None background--primary-light-gradient\" aria-labelledby=\"OttawaCitizenEveningUpdate3895930205113231511616969013985280\" data-account-id=\"b9d3df2fccd108b5eff3c44f573b2cd6\" data-aqa=\"widget-newsletter\" data-newsletter=\"single\" data-newsletter-component=\"\" data-target-list=\"OC_Covid19_Newsletter\" data-widget=\"newsletter\">\n<div class=\"newsletter-new-story-page-template\">\n<div class=\"newsletter-widget__header__new-story-page\">\n<div class=\"newsletter-widget__banner__new-story-page\"><img decoding=\"async\" alt=\"Ottawa Citizen\" loading=\"lazy\" src=\"https:\/\/dcs-static.gprod.postmedia.digital\/17.1.1\/websites\/images\/newsletters\/icon-oc-eveningUpdate.svg\"\/><\/div>\n<div>\n<p>Evening Update<\/p>\n<p class=\"newsletter-widget__text__new-story-page\">The Ottawa Citizen\u2019s best journalism, delivered directly to your inbox by 7 p.m. on weekdays.<\/p>\n<\/div>\n<\/div>\n<div class=\"newsletter-widget__body__new-story-page\">\n<div class=\"js-replace-main__new-story-page\">\n<p class=\"newsletter-widget__disclaimer__new-story-page text-size--tiny\">By signing up you consent to receive the above newsletter from Postmedia Network Inc.<\/p>\n<\/div>\n<div class=\"js-submit-success\" hidden=\"\" id=\"submitSuccessOC_Covid19_Newsletter\">\n<p>Thanks for signing up!<\/p>\n<p class=\"newsletter-widget__text__new-story-page\">A welcome email is on its way. If you don&#8217;t see it, please check your junk folder.<\/p>\n<p class=\"newsletter-widget__text__new-story-page newsletter__feedback--last\">The next issue of Evening Update will soon be in your inbox.<\/p>\n<\/div>\n<p class=\"newsletter-widget__text__new-story-page js-submit-error\" style=\"margin-top: 8px\" hidden=\"\" id=\"submitErrorOC_Covid19_Newsletter\">We encountered an issue signing you up. Please try again<\/p>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_4\">\n<section aria-describedby=\"advertisment6287143773745396140568016272228352\" class=\"ad\">\n<p>Advertisement 4<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-4\">\n<div class=\"ad__inner__container\" data-ad=\"[[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-loc=\"4\" data-ad-mobile=\"[[320,50],[300,50],[300,250]]\" data-aqa=\"advertisement\" id=\"ad-4\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>\u201cI think we need mucosal vaccines generally. I think we are going to see a future with mucosal vaccines, and they have a whole variety of possible indications beyond COVID,\u201d Miller said. \u201cOur propensity to stick (vaccines) into peoples\u2019 arms is more out of habit than anything else.\u201d<\/p>\n<p>But Miller and others warn that expectations should be tempered for just how much, and how quickly, mucosal vaccines can make a difference.<\/p>\n<p>Still, many people have high hopes.<\/p>\n<p>Just last month, early, promising data from a mucosal vaccine being developed in China created a buzz. In the midst of early-stage testing of the vaccine, China lifted its highly restrictive Zero COVID policy, resulting in a massive wave. Still, more than 86 per cent of people who had two doses of the experimental vaccine remained uninfected. The vaccine is still undergoing testing.<\/p>\n<p>\u201cThis is what I\u2019ve been waiting for. It could finally give us a real ending to the pandemic,\u201d Toronto emergency physician Dr. Kashif Pirzada wrote on the social media platform X in response to the results of a study on the Chinese vaccine. \u201cNo more waves of illness, no more rushing for tests and antivirals if you\u2019re elderly or vulnerable. Hope this comes out soon!\u201d<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_5\">\n<section aria-describedby=\"advertisment6746566570431097619798208628654080\" class=\"ad\">\n<p>Advertisement 5<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-5\">\n<div class=\"ad__inner__container\" data-ad=\"[[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-loc=\"5\" data-ad-mobile=\"[[320,50],[300,50],[300,250]]\" data-aqa=\"advertisement\" id=\"ad-5\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>Pirzada is a board member of the national non-profit Canadian Covid Society, which was founded, in part, to fill information gaps after public health pulled back on public awareness campaigns and preventative measures.<\/p>\n<p>University of Ottawa professor Dr. Marc-Andr\u00e9 Langlois, whose lab has also worked on a mucosal vaccine for COVID-19, said the world had been fortunate to have vaccines that could be deployed rapidly during the early months of the pandemic. \u201cThey worked very well to reduce severe disease symptoms in those who got infected. The key point, though, is they worked in those who got infected.\u201d<\/p>\n<p>The advantage of mucosal vaccines, he said, is the possibility that \u201cyou don\u2019t get infected.\u201d Langlois envisages a future in which mucosal vaccines could be sold off the shelf in pharmacies and easily administered at home.<\/p>\n<figure class=\"embedded-image\" data-aqa=\"embed-image\"><picture class=\"embedded-image__ratio\"><source data-srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=564&amp;type=webp&amp;sig=YwM6sm8OJZsAnFkzGWgJVQ,&#10;            https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=1128&amp;type=webp&amp;sig=cE7VtgGGU0on8Pm0iWT2QQ 2x\" media=\"(min-width: 1200px)\" srcset=\"data:,1w\" type=\"image\/webp\"><source data-srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=564&amp;type=jpg&amp;sig=7mCqLXNCCv_eKXbCeiTDQg,&#10;                https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=1128&amp;type=jpg&amp;sig=qMWvxvTenKEnW8xKqS5pXw 2x\" media=\"(min-width: 1200px)\" srcset=\"data:,1w\" type=\"image\/jpeg\"><source data-srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=472&amp;type=webp&amp;sig=5ZRKQB5iTYKIYDGqRJpXXQ,&#10;            https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=944&amp;type=webp&amp;sig=dKGOYn8HFil6t75Jf-_-1A 2x\" media=\"(min-width: 768px)\" srcset=\"data:,1w\" type=\"image\/webp\"><source data-srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=472&amp;type=jpg&amp;sig=-dvijviCZ0EkvY0r7ZCG7Q,&#10;                https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=944&amp;type=jpg&amp;sig=GyCn_YO-4R_IIPRtiACWMg 2x\" media=\"(min-width: 768px)\" srcset=\"data:,1w\" type=\"image\/jpeg\"><source data-srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=288&amp;type=webp&amp;sig=Lo816iFD1hCnj18_PNtpug,&#10;            https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=576&amp;type=webp&amp;sig=5oTibDbsILsjR2SPGeIxGA 2x\" media=\"(max-width: 767px)\" srcset=\"data:,1w\" type=\"image\/webp\"><img decoding=\"async\" alt=\"Marc-Andr\u00e9 Langlois and Allyson MacLean,\" class=\"embedded-image__image lazyload\" data-src=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=288&amp;sig=CVAmGn_ZNCFI38J3-jzlZQ\" data-srcset=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=288&amp;sig=CVAmGn_ZNCFI38J3-jzlZQ,&#10;                https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=90&amp;strip=all&amp;w=576&amp;sig=OGcdqnf_xkQwMvgjF2ksBw 2x\" src=\"https:\/\/smartcdn.gprod.postmedia.digital\/ottawacitizen\/wp-content\/uploads\/2024\/10\/138797.jpg?quality=5&amp;strip=all&amp;w=100&amp;sig=xsvvKseAFk-K38I7R5pBPQ\" height=\"750\" loading=\"lazy\" width=\"1000\"\/><\/source><\/source><\/source><\/source><\/source><\/picture><figcaption class=\"image-caption\"><span class=\"caption\"> Marc-Andr\u00e9 Langlois and Allyson MacLean, uOttawa researchers, were working on a plant-based nasal COVID booster vaccine until government funding ended.<\/span> <span class=\"credit\">Photo by Jean Levac<\/span> \/<span class=\"distributor\">Postmedia<\/span><\/figcaption><\/figure>\n<p>Langlois knows the subject well: A molecular virologist with a background in immunology who is executive director of the national Coronavirus Variants Rapid Response Network, his work focused on HIV until the pandemic hit. He re-tooled his lab to work on COVID-19, including the development of a plant-based nasal spray vaccine.<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_6\">\n<section aria-describedby=\"advertisment370315132737923936939576139972608\" class=\"ad\">\n<p>Advertisement 6<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-6\">\n<div class=\"ad__inner__container\" data-ad=\"[[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-loc=\"6\" data-ad-mobile=\"[[320,50],[300,50],[300,250]]\" data-aqa=\"advertisement\" id=\"ad-6\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>But that project, which began in June 2021, is being shelved after funding ended. He calls the lack of federal government interest in the project and other pandemic-related work discouraging and short-sighted, especially since the potential of mucosal vaccines \u2014 for COVID-19 and beyond \u2014 is huge.<\/p>\n<p>\u201cThey are the key to stopping transmission, and really that is what we want, to completely prevent infection. The research will be applied to influenza and other respiratory viruses as well,\u201d he said.<\/p>\n<p>Miller and the team at McMaster were already working on an inhaled vaccine for tuberculosis when the pandemic hit. With pandemic funding, they pivoted to work on a mucosal COVID-19 vaccine.<\/p>\n<p>The researchers recognized that all the vaccines being developed by major pharmaceutical companies at the beginning of the pandemic were unlikely to end the pandemic. They all focused on the spike protein in SARS-CoV-2, the virus that causes COVID-19. That spike protein mutates quickly, which is why vaccines need to be updated and boosted frequently to protect against new strains.<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_7\">\n<section aria-describedby=\"advertisment9363918727310986412786020297736192\" class=\"ad\">\n<p>Advertisement 7<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-7\">\n<div class=\"ad__inner__container\" data-ad=\"[[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-loc=\"7\" data-ad-mobile=\"[[320,50],[300,50],[300,250]]\" data-aqa=\"advertisement\" id=\"ad-7\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>The mucosal vaccine being tested in Miller\u2019s lab focuses on other parts of the virus, in addition to spike protein, which will hopefully reduce, or end, the need for frequent vaccinations.<\/p>\n<p>\u201cThe whole point of our vaccine was to get away from the need for constant boosters and chasing variants. That is what we are shooting for.\u201d<\/p>\n<p>Their vaccine uses the same viral vector \u2014 adenovirus \u2014 to prime an immune response as was used in several injected COVID-19 vaccines associated with a higher risk of rare but potentially dangerous clotting (known as vaccine-induced immune thrombotic thrombocytopenia or VITT). Health Canada suspended use of the AstraZeneca-Oxford vaccine in people under 55, Janssen withdrew its vaccine.\u00a0<span\/><\/p>\n<p>Miller noted that the scientific community does not fully understand why VITT happens in rare cases, \u201cbut it seems as though \u2018leakage\u2019 of the adenovirus vaccine into the bloodstream when it is injected may be responsible. Because our vaccine is inhaled and non-replicating, it only ever reaches (the lungs) and as far as we know does not reach the bloodstream. This is a key difference that we think will overcome the important safety concern around VITT.\u201d<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_8\">\n<section aria-describedby=\"advertisment2313579565818614154986239356305408\" class=\"ad\">\n<p>Advertisement 8<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-8\">\n<div class=\"ad__inner__container\" data-ad=\"[[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-loc=\"8\" data-ad-mobile=\"[[320,50],[300,50],[300,250]]\" data-aqa=\"advertisement\" id=\"ad-8\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>He said there were no \u201cworrisome safety signals\u201d detected in the relatively small Phase 1 study, and it will continue to be monitored closely.<\/p>\n<p>The urgency of the pandemic expedited research on inhaled vaccines \u201cthat may benefit humanity far beyond the pandemic,\u201d Miller wrote. Early research in animals suggested the inhaled COVID-19 vaccine currently being tested \u201cwill last longer, be more effective and stand up well to future variants of the COVID-19 virus.\u201d<\/p>\n<p>Miller is cautious, though, about broader hopes that mucosal vaccines will offer complete so-called \u201csterilizing immunity\u201d \u2014 an end to infections.<\/p>\n<p>\u201cI think it is important to give the public realistic expectations,\u201d he said. \u201cThey are not going to be perfect.\u201d<\/p>\n<p>He is far from alone in his caution. A recent article in the journal eBio Medicine titled \u201cMucosal vaccines for SARS-CoV-2: triumph of hope over experience,\u201d argued that more work needs to be done on the vaccines. Its authors noted that mucosal vaccines are known for being safe, easy to administer and cost-effective, but proof that they offer better mucosal immunity (than current vaccines) and prevent infection and transmission \u201cremains elusive.\u201d<\/p>\n<\/section>\n<div class=\"ad__section-border article-content__ad-group ad_counter_9\">\n<section aria-describedby=\"advertisment6749383223453974752042445321535488\" class=\"ad\">\n<p>Advertisement 9<\/p>\n<div class=\"ad__container\">\n<div class=\"ad__inner\" id=\"ad__inner-9\">\n<div class=\"ad__inner__container\" data-ad=\"[[1200,250],[1200,90],[970,90],[970,250],[728,90],[300,250]]\" data-ad-loc=\"9\" data-ad-mobile=\"[[320,50],[300,50],[300,250]]\" data-aqa=\"advertisement\" id=\"ad-9\" style=\"--desktopHeight:250px;--mobileHeight:250px\">\n<div aria-hidden=\"true\" class=\"ad__placeholder\">\n<p>This advertisement has not loaded yet, but your article continues below.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<p>Miller says the virus that causes COVID-19 is unlikely to disappear completely. \u201cThis virus is just too good at spreading.\u201d<\/p>\n<p>But it is likely the virus will begin to exhibit more predictable seasonal circulation patterns, similar to influenza, RSV and the common cold, which are also coronaviruses.<\/p>\n<p>\u201cThat, I think, is possible,\u201d Miller said.<\/p>\n<p>\u201cSettling into a place where COVID behaves much more like a common cold virus would be a huge step in the right direction.\u201d<\/p>\n<div><i>Our website is your destination for up-to-the-minute news, so make sure to bookmark our homepage and<span>\u00a0<\/span><a rel=\"noopener noreferrer\" class=\"OWAAutoLink\" data-auth=\"NotApplicable\" data-linkindex=\"2\" data-loopstyle=\"linkonly\" href=\"https:\/\/ottawacitizen.com\/newsletters\/\" target=\"_blank\" title=\"https:\/\/ottawacitizen.com\/newsletters\/\">sign up for our newsletters<\/a>\u00a0so we can keep you informed.<\/i><\/div>\n<\/section>\n<section class=\"article-content__content-group article-content__content-group--story\">\n<p>Article content<\/p>\n<\/section>\n<section class=\"article-content__share-group article-delimiter\" data-evt-val=\"{\" control_fields=\"\" data-evt-typ=\"page_scroll\">\n<p>Share this article in your social network<\/p>\n<\/section>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/ottawacitizen.com\/news\/local-news\/is-this-the-way-covid-ends-next-generation-nasal-vaccines-could-be-the-key-to-end-the-pandemic\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Breadcrumb Trail Links Local News Existing COVID-19 vaccines can prevent severe disease, but not infection. A new hope comes in the form of needle-free mucosal vaccines. Get the latest from &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=112749\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-112749","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/112749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=112749"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/112749\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=112749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=112749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=112749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}