{"id":112844,"date":"2024-10-11T08:28:47","date_gmt":"2024-10-11T01:28:47","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=112844"},"modified":"2024-10-11T08:28:47","modified_gmt":"2024-10-11T01:28:47","slug":"your-cells-get-all-their-power-from-mothers-dna","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=112844","title":{"rendered":"Your cells get all their power from mother&#8217;s DNA"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<div class=\"post-featured-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"900\" alt=\"cool mom\" src=\"https:\/\/studyfinds.org\/wp-content\/uploads\/2021\/04\/pexels-katie-e-3662770-scaled-e1728585853296-1200x900.jpg\"\/><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"900\" src=\"https:\/\/studyfinds.org\/wp-content\/uploads\/2021\/04\/pexels-katie-e-3662770-scaled-e1728585853296-1200x900.jpg\" alt=\"cool mom\"\/><\/p>\n<p class=\"post-featured-image-caption\">(Credit: Katie E from Pexels)<\/p>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p><strong>BOULDER, Colo. \u2014 <\/strong>Are you an energizer bunny or constantly find yourself battling feelings of fatigue? The answer likely has a lot to do with your mother. Although science tells us that half our genes come from Mom and half from Dad, a new study has discovered that the tiny power plants, called mitochondria, in our cells only contain DNA from our mothers.<\/p>\n<p>So, what happened to your father\u2019s mitochondrial genes? Researchers from the University of Colorado Boulder have found that they\u2019re destroyed right when sperm meets egg.<\/p>\n<p>Why does this happen? Moreover, what if it doesn\u2019t work properly? The study, published in the journal <em><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adp8351\" target=\"_blank\" rel=\"noreferrer noopener nofollow external\" data-wpel-link=\"external\">Science Advances<\/a><\/em>, is shedding light on these questions. The answers could significantly impact our understanding of certain rare but serious diseases.<\/p>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>First, let\u2019s break down what <a href=\"https:\/\/studyfinds.org\/tag\/mitochondria\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" data-wpel-link=\"internal\">mitochondria<\/a> actually are. You can think of them as tiny batteries inside almost every cell in your body. Their job is to produce a chemical called ATP (adenosine triphosphate), which is essentially the energy currency that powers nearly everything your cells do.<\/p>\n<p>What makes mitochondria special is that they have their own DNA, separate from the DNA in the cell\u2019s nucleus. In most animals, including humans, this mitochondrial DNA comes <a href=\"https:\/\/studyfinds.org\/young-mothers-more-likely-to-have-children-with-adhd-study-finds\/\" target=\"_blank\" rel=\"noreferrer noopener\" data-wpel-link=\"internal\">exclusively from the mother<\/a>.<\/p>\n<p>\u201cIt could be humiliating for a guy to hear, but it\u2019s true. Our stuff is so undesirable that evolution has designed multiple mechanisms to make sure it is cleared during reproduction,\u201d explains Dr. Ding Xue, a professor at UC Boulder and senior author of the study, in a media release.<\/p>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>So, what happens if this process, called \u201cpaternal mitochondria elimination\u201d (PME for short), doesn\u2019t work properly? That\u2019s what Xue and his team set out to discover.<\/p>\n<p>They turned to a tiny worm called C. elegans for their experiments. Don\u2019t let its size fool you \u2013 this worm has a nervous system, gut, and muscles similar to humans, making it a great model for this kind of research.<\/p>\n<p>The scientists couldn\u2019t completely stop PME from happening (which shows just how important this process is), but they managed to delay it by about 10 hours. The striking results revealed that developing embryos had much lower levels of ATP, meaning less energy to fuel their growth. Many of the worms didn\u2019t survive at all. Those who did survive had trouble thinking clearly, showed unusual activity patterns, and had difficulty reproducing. In simpler terms, letting Dad\u2019s mitochondrial DNA hang around caused some serious problems.<\/p>\n<\/div>\n<div class=\"wp-block-group has-octonary-background-color has-background is-layout-constrained wp-block-group-is-layout-constrained\">\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"790\" alt=\"diagram of Mitochondria\" class=\"wp-image-125061\" srcset=\"https:\/\/studyfinds.org\/wp-content\/uploads\/2024\/03\/mitochondria.jpeg 1200w, https:\/\/studyfinds.org\/wp-content\/uploads\/2024\/03\/mitochondria-400x263.jpeg 400w\" data-lazy-sizes=\"(max-width: 1200px) 100vw, 1200px\" src=\"https:\/\/studyfinds.org\/wp-content\/uploads\/2024\/03\/mitochondria-1200x790.jpeg\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"790\" src=\"https:\/\/studyfinds.org\/wp-content\/uploads\/2024\/03\/mitochondria-1200x790.jpeg\" alt=\"diagram of Mitochondria\" class=\"wp-image-125061\" srcset=\"https:\/\/studyfinds.org\/wp-content\/uploads\/2024\/03\/mitochondria.jpeg 1200w, https:\/\/studyfinds.org\/wp-content\/uploads\/2024\/03\/mitochondria-400x263.jpeg 400w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><figcaption class=\"wp-element-caption\">Diagram of Mitochondria (\u00a9 L.Darin \u2013 stock.adobe.com)<\/figcaption><\/figure>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>Here\u2019s where things get really interesting. The researchers found that treating the worms with a form of <a href=\"https:\/\/studyfinds.org\/vitamin-k-cell-death\/\" target=\"_blank\" rel=\"noreferrer noopener\" data-wpel-link=\"internal\">vitamin K2<\/a> (specifically, a type called MK-4) seemed to fix many of these issues. It brought ATP levels back to normal in the embryos and improved memory, activity, and reproduction in the adult worms.<\/p>\n<p>This finding opens up exciting possibilities for potential treatments in humans. Dr. Xue speculates that someday, families with a history of mitochondrial disorders might take vitamin K2 as a precautionary measure during pregnancy.<\/p>\n<p>Now, you might be wondering \u2013 does this actually happen in humans? While it\u2019s rare, there have been a few documented cases where scientists think they\u2019ve found traces of paternal mitochondrial DNA in adults.<\/p>\n<p>One case involved a 28-year-old man who had trouble breathing, weak muscles, and couldn\u2019t handle exercise. Another study looked at 17 people from three different families who experienced <a href=\"https:\/\/studyfinds.org\/long-covid-fatigue-2-years\/\" target=\"_blank\" rel=\"noreferrer noopener\" data-wpel-link=\"internal\">fatigue<\/a>, muscle pain, speech delays, and neurological symptoms.<\/p>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>While more research is necessary, Dr. Xue suspects that in some cases, even a small delay in getting rid of Dad\u2019s mitochondrial DNA could be behind some hard-to-diagnose diseases.<\/p>\n<p>\u201cIf you have a problem with ATP it can impact every stage of the human life cycle,\u201d the study author explains.<\/p>\n<p>This research doesn\u2019t just help us understand a quirky biological process. It could have major implications for diagnosing and treating a group of conditions called <a href=\"https:\/\/studyfinds.org\/parents-drinking-accelerated-aging\/\" target=\"_blank\" rel=\"noreferrer noopener\" data-wpel-link=\"internal\">mitochondrial disorders<\/a>. These diseases, which affect about one in 5,000 people, happen when mitochondria don\u2019t work properly, leaving the body struggling to produce enough energy.<\/p>\n<p>\u201cThere are a lot of diseases that are poorly understood. No one really knows what is going on. This research offers clues,\u201d Dr. Xue says. <\/p>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<p>While we\u2019re still a long way from definitive treatments based on this study, it opens up new avenues for research. It might lead to better ways to diagnose mitochondrial disorders or even novel treatment approaches.<\/p>\n<p>So, the next time you think about inheritance, remember \u2013 while you\u2019re a mix of both your parents in many ways, the tiny power plants in your cells are all thanks to Mom. That specialized inheritance pattern might be more important to your health than anyone realized.<\/p>\n<\/div>\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-group has-quaternary-background-color has-background is-layout-constrained wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\" id=\"h-paper-summary\">Paper Summary<\/h2>\n<h4 class=\"wp-block-heading\" id=\"h-methodology\">Methodology<\/h4>\n<p>The study focused on <em>Caenorhabditis elegans<\/em> (a small worm) to explore how a delay in removing the father\u2019s mitochondria during early development impacts the adult animals\u2019 behavior and cognitive function. Normally, after fertilization, the father\u2019s mitochondria are quickly eliminated, but the researchers caused a slight delay in this process. They achieved this delay by altering a specific gene in the worms.<\/p>\n<p>The scientists then measured energy production in the embryos and tested the adult worms\u2019 behaviors, like mating, memory, and movement patterns. They also used a special vitamin (MK-4) to see if it could fix the problems caused by the delayed mitochondrial removal.<\/p>\n<h4 class=\"wp-block-heading\" id=\"h-key-results\">Key Results<\/h4>\n<p>The study found that even a slight delay in getting rid of the father\u2019s mitochondria in the embryos caused significant changes in adult worms. These changes included problems with mating, memory, and movement. The delayed mitochondrial removal reduced energy production in the embryos, which seemed to cause these problems in the adult worms. Interestingly, when the scientists treated the worms with MK-4 (a type of vitamin K), the energy levels were restored, and the worms\u2019 behaviors improved.<\/p>\n<h4 class=\"wp-block-heading\" id=\"h-study-limitations\">Study Limitations<\/h4>\n<p>One limitation of the study is that it was conducted on worms, which may not perfectly represent what happens in humans. Additionally, the delay in mitochondrial removal was created artificially in the lab, so it\u2019s unclear how often this would naturally occur in real-life conditions. The study also focused on a specific genetic mutation, which may not apply to all types of mitochondrial issues.<\/p>\n<h4 class=\"wp-block-heading\" id=\"h-discussion-amp-takeaways\">Discussion &amp; Takeaways<\/h4>\n<p>The study suggests that even a brief delay in eliminating paternal mitochondria during development can have lasting negative effects on important functions like mating and memory in adult animals. This indicates that the quick removal of paternal mitochondria is crucial for normal development. The study also opens up the possibility that treatments like MK-4 could help fix mitochondrial-related problems in other organisms, including humans. This could be especially important for understanding certain diseases caused by mitochondrial dysfunction.<\/p>\n<h4 class=\"wp-block-heading\" id=\"h-funding-amp-disclosures\">Funding &amp; Disclosures<\/h4>\n<p>The research was supported by the NIH grant R35 GM118188 and March of Dimes grant 1-FY17-655 (D.X.). Some strains were provided by the Caenorhabditis Genetics Center, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). The authors declare that they have no competing interests.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/studyfinds.org\/cells-get-power-mothers-dna\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Credit: Katie E from Pexels) BOULDER, Colo. \u2014 Are you an energizer bunny or constantly find yourself battling feelings of fatigue? The answer likely has a lot to do with &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=112844\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8628],"tags":[],"class_list":["post-112844","post","type-post","status-publish","format-standard","hentry","category-science","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/112844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=112844"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/112844\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=112844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=112844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=112844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}