{"id":113161,"date":"2024-10-12T04:03:51","date_gmt":"2024-10-11T21:03:51","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=113161"},"modified":"2024-10-12T04:03:51","modified_gmt":"2024-10-11T21:03:51","slug":"hdl-cholesterol-quality-not-quantity-linked-to-alzheimers-risk","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=113161","title":{"rendered":"HDL Cholesterol Quality, Not Quantity, Linked to Alzheimer\u2019s Risk"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Higher levels of HDL, the so-called \u201cgood cholesterol,\u201d may not protect against Alzheimer\u2019s in postmenopausal women, with the risk potentially tied to the quality, not quantity, of HDL particles. A new study shows that larger HDL particles, which increase during menopause, lose efficiency in supporting cognitive health.<\/p>\n<p>Researchers found that women with more smaller HDL particles and phospholipid-rich particles in midlife maintained better memory over time. The study suggests that health behaviors can improve HDL quality, aiding brain health. This adds to evidence that lifestyle changes, even in one\u2019s 40s, may reduce Alzheimer\u2019s risk in later years.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>HDL quality, not just levels, is linked to cognitive health in postmenopausal women.<\/li>\n<li>Larger, less functional HDL particles increase as women transition through menopause.<\/li>\n<li>Lifestyle factors can improve HDL quality, potentially supporting brain health.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Pittsburgh<\/p>\n<p><strong>Higher levels of HDL-C\u2014known as the \u201cgood cholesterol\u201d\u2014have been shown to correlate with\u00a0heightened risk for Alzheimer\u2019s disease. <\/strong><\/p>\n<p>A new study published in\u00a0the\u00a0<em>Journal of Clinical Endocrinology &amp; Metabolism<\/em>\u00a0might explain why.<\/p>\n<p>Once women reach the menopause transition, it\u2019s a matter of the quality, rather than quantity, of the total cholesterol carried by HDL particles circulating in a woman\u2019s bloodstream, and that quality declines over time, according to a research team led by a University of Pittsburgh School of Public Health epidemiologist.<\/p>\n<p>HDL particles vary in their size, composition and level of functioning. The team measured these features in the blood of 503 women from the\u00a0Study of Women\u2019s Health Across the Nation (SWAN)\u00a0HDL ancillary study.<\/p>\n<p>The researchers found that, over time, the number of larger HDL particles in the women\u2019s bodies increased\u2014and these larger particles, unfortunately, did not function as well as their smaller counterparts.\u00a0<\/p>\n<p>The researchers conducted repeated assessments of study participants\u2019 cognitive function from 2000 to 2016 and compared these data to changes in the women\u2019s HDL particles, composition and function as they aged.<\/p>\n<p>\u201cWe were able to show that as early as midlife, women who have more of the smaller-sized particles and those whose particles\u2019 concentrations of phospholipids increased over the menopause transition are more likely to experience better episodic memory later in life,\u201d said\u00a0Samar R. El Khoudary, Ph.D., M.P.H., professor of\u00a0epidemiology at Pitt Public Health, adding that loss of working memory is the first sign of Alzheimer\u2019s disease.<\/p>\n<p>Previously, El Khoudary\u2019s team has shown that health behaviors\u2014such as those included in the American Heart Association\u2019s (AHA)\u00a0Life\u2019s Essential 8\u2014work to improve the quality of HDL particles, for example by adding more of the phospholipid-rich particles in the bloodstream.<\/p>\n<p>\u201cThat\u2019s the good news in this developing picture of brain health and the \u2018not-so-good-after-all\u2019 cholesterol,\u201d said El Khoudary.<\/p>\n<p>\u201cEven though higher levels of HDL-C may not be protective as you get older, there are things you can do that might help, even as early as your 40s. The same, modifiable risk factors that the AHA is advocating for\u2014including physical activity, ideal body weight and quitting smoking\u2014can help you protect your brain, too.\u201d\u00a0<\/p>\n<p>Meiyuzhen Qi, Ph.D., post-doctoral researcher in the Department of Epidemiology at Pitt Public Health, is first author of this study.<\/p>\n<p>Additional coauthors include scientists from the University of Pennsylvania Perelman School of Medicine, Rush University Rush Medical Center, University of California Los Angeles David Geffen School of Medicine, Albert Einstein College of Medicine, University of Michigan School of Public Health and University of Massachusetts Medical School.<\/p>\n<h2 class=\"wp-block-heading\">About this Alzheimer\u2019s disease research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#cea6b7aab4a7a5afa38ebbbea3ade0abaabb\" target=\"_blank\" rel=\"noreferrer noopener\">Allison Hydzik<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/upmc.edu\" target=\"_blank\" rel=\"noreferrer noopener\">University of Pittsburgh<\/a><br \/><strong>Contact: <\/strong>Allison Hydzik \u2013 University of Pittsburgh<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/academic.oup.com\/jcem\/advance-article-abstract\/doi\/10.1210\/clinem\/dgae697\/7811361\" target=\"_blank\" rel=\"noreferrer noopener\">High-density lipoprotein over midlife and future cognition in women: The SWAN HDL ancillary study<\/a>\u201d by Samar R. El Khoudary et al. <em><em>The Journal of Clinical Endocrinology &amp; Metabolism<\/em><\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>High-density lipoprotein over midlife and future cognition in women: The SWAN HDL ancillary study<\/strong><\/p>\n<p><strong>Context<\/strong><\/p>\n<p>Limited data provides evidence-based insights on the association between comprehensive metrics of high-density lipoproteins (HDL) and cognitive performance, especially in midlife women for whom benefit might be the greatest.<\/p>\n<p><strong>Objective<\/strong><\/p>\n<p>To assess the associations of serum HDL metrics including HDL lipid content [HDL cholesterol, phospholipid (HDL-PL), triglyceride], proteins\/subclasses [apolipoprotein A-1 (apoA-1); small, medium, large, total HDL particle (HDL-P); and HDL size], and cholesterol efflux capacity with cognitive performance in midlife women.<\/p>\n<p><strong>Methods<\/strong><\/p>\n<p>This prospective cohort study was conducted among 503 midlife women (1234 observations) from the Study of Women\u2019s Health Across the Nation HDL ancillary study. Joint models were applied to examine associations of HDL metrics assessed at midlife (50.2 \u00b1\u00a02.9 years, baseline of the current study) and their changes over midlife (6.1 \u00b1\u00a03.9 years of duration) with subsequent cognitive performance [working memory (Digit Span Backward Test), processing speed (Symbol Digit Modalities Test), and episodic memory immediate and delayed recall (East Boston memory test)] assessed repeatedly (maximum 5 times) 1.5 \u00b1\u00a01 years later over 7.72 \u00b1 4.10 years of follow up.<\/p>\n<p><strong>Results<\/strong><\/p>\n<p>Higher total HDL-P and smaller HDL size at midlife were associated with a better subsequent immediate recall, delayed recall and\/or processing speed. Greater increase in HDL-PL, apoA-1, medium HDL-P, and total HDL-P and less increase in HDL size over midlife were associated with a better subsequent immediate and\/or delayed recall.<\/p>\n<p><strong>Conclusions<\/strong><\/p>\n<p>Enhancing specific serum HDL metrics during midlife could be promising in cognitive restoration, particularly memory, the initial and predominant symptom of Alzheimer\u2019s disease.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/hdl-cholesterol-alzheimers-27844\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Higher levels of HDL, the so-called \u201cgood cholesterol,\u201d may not protect against Alzheimer\u2019s in postmenopausal women, with the risk potentially tied to the quality, not quantity, of HDL particles. &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=113161\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-113161","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/113161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=113161"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/113161\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=113161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=113161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=113161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}