{"id":113366,"date":"2024-10-12T17:00:49","date_gmt":"2024-10-12T10:00:49","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=113366"},"modified":"2024-10-12T17:00:49","modified_gmt":"2024-10-12T10:00:49","slug":"ferroptosis-findings-offer-hope-for-cancer-and-cell-protection","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=113366","title":{"rendered":"Ferroptosis Findings Offer Hope for Cancer and Cell Protection"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Scientists have uncovered a new pathway regulating cell death, or ferroptosis, which could pave the way for innovative cancer treatments. By examining how oxidative stress damages lipid membranes, the team found that the proteasome recycling system becomes clogged, accelerating cell destruction.<\/p>\n<p>Importantly, they identified an enzyme, DDI2, that helps clear these blockages and could be therapeutically targeted. This discovery sheds light on how ferroptosis can be controlled, potentially allowing for selective targeting of cancer cells while sparing healthy cells. The research opens avenues for both new cancer treatments and ways to protect cells from death due to disease.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>Ferroptosis is a form of programmed cell death triggered by oxidative lipid damage.<\/li>\n<li>The enzyme DDI2 aids in protecting cells by unclogging the proteasome recycling system.<\/li>\n<li>Targeting DDI2 could provide therapies that selectively influence cancer cell death.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>LMU<\/p>\n<p><strong>Programmed cell death protects the body against cancer and other diseases. A team of researchers led by Professor\u00a0Alexander Bartelt\u00a0from the\u00a0Institute for Cardiovascular Prevention (IPEK)\u00a0has decoded a new mechanism by which oxidative stress influences cell death. <\/strong><\/p>\n<p>The researchers hope this discovery will lead to novel approaches for targeting cancer cells and other diseases. Their findings were recently published in the journal\u00a0<em>Cell Death &amp; Differentiation<\/em>.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105350\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence.jpg\" alt=\"This shows cells.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/ferroptosis-oxidative-stress-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Using state-of-the-art methods of mass spectrometry, the team investigated whether the recycling of proteins is disrupted during ferroptosis. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>When the lipids in the plasma are attacked, it is referred to as ferroptosis. In a chain reaction, the lipid molecules that make up the membrane are being destroyed and the cell literally dissolves.\u00a0<\/p>\n<p>\u201cFerroptosis is a recently discovered form of cell death and we\u2019re searching for ways to control the process,\u201d says Bartelt.<\/p>\n<p>The team concentrated on the proteasome, which functions as a sort of recycling bin for the cell. Through the operations of the proteasome, old or damaged proteins are broken down and made available to the cell again.<\/p>\n<p>Using state-of-the-art methods of mass spectrometry, the team investigated whether the recycling of proteins is disrupted during ferroptosis. In this way, the researchers found that the proteasome is effectively clogged up, accelerating cell death. At the same time, they identified the enzyme DDI2, which cranks up the recycling again and protects against cell death.<\/p>\n<p>\u201cDDI2 is a protease \u2013 a type of enzyme it\u2019s possible to therapeutically influence,\u201d says Anahita Ofoghi, who carried out the study.<\/p>\n<p>The findings point to a new way of manipulating cell death. This could be relevant not only for new cancer therapies, but also indicates how we might be able to protect healthy cells against death.<\/p>\n<p>\u201cWe\u2019ve contributed a small piece to the fascinating puzzle of ferroptosis,\u201d says Bartelt.<\/p>\n<p>The authors now hope to exploit this molecular mechanism for therapies.<\/p>\n<h2 class=\"wp-block-heading\">About this ferroptosis and brain cancer research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#22410c465047554e4d624e4f570c4647\" target=\"_blank\" rel=\"noreferrer noopener\">Constanze Drewlo<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/lmu.de\" target=\"_blank\" rel=\"noreferrer noopener\">LMU<\/a><br \/><strong>Contact: <\/strong>Constanze Drewlo \u2013 LMU<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.nature.com\/articles\/s41418-024-01398-z\" target=\"_blank\" rel=\"noreferrer noopener\">Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis<\/a>\u201d by Alexander Bartelt et al. <em><em>Cell Death and Differentiation<\/em><\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis<\/strong><\/p>\n<p>Ferroptosis is an iron-dependent, non-apoptotic form of cell death initiated by oxidative stress and lipid peroxidation.<\/p>\n<p>Recent evidence has linked ferroptosis to the action of the transcription factor Nuclear factor erythroid-2 derived,-like-1 (NFE2L1). NFE2L1 regulates proteasome abundance in an adaptive fashion, maintaining protein quality control to secure cellular homeostasis, but the regulation of NFE2L1 during ferroptosis and the role of the ubiquitin-proteasome system (UPS) herein are still unclear.<\/p>\n<p>In the present study, using an unbiased proteomic approach charting the specific ubiquitylation sites, we show that induction of ferroptosis leads to recalibration of the UPS. RSL3-induced ferroptosis inhibits proteasome activity and leads to global hyperubiquitylation, which is linked to NFE2L1 activation. As NFE2L1 resides in the endoplasmic reticulum tethered to the membrane, it undergoes complex posttranslational modification steps to become active and induce the expression of proteasome subunit genes.<\/p>\n<p>We show that proteolytic cleavage of NFE2L1 by the aspartyl protease DNA-damage inducible 1 homolog 2 (DDI2) is a critical step for the ferroptosis-induced feed-back loop of proteasome function. Cells lacking DDI2 cannot activate NFE2L1 in response to RSL3 and show global hyperubiquitylation.<\/p>\n<p>Genetic or chemical induction of ferroptosis in cells with a disrupted DDI2-NFE2L1 pathway diminishes proteasomal activity and promotes cell death. Also, treating cells with the clinical drug nelfinavir, which inhibits DDI2, sensitized cells to ferroptosis. In conclusion, our results provide new insight into the importance of the UPS in ferroptosis and highlight the role of the DDI2-NFE2L1 as a potential therapeutic target.<\/p>\n<p>Manipulating DDI2-NFE2L1 activity through chemical inhibition might help sensitizing cells to ferroptosis, thus enhancing existing cancer therapies.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/ferroptosis-oxidative-stress-27844\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Scientists have uncovered a new pathway regulating cell death, or ferroptosis, which could pave the way for innovative cancer treatments. By examining how oxidative stress damages lipid membranes, the &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=113366\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8628],"tags":[],"class_list":["post-113366","post","type-post","status-publish","format-standard","hentry","category-science","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/113366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=113366"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/113366\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=113366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=113366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=113366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}