{"id":113888,"date":"2024-10-14T02:50:52","date_gmt":"2024-10-13T19:50:52","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=113888"},"modified":"2024-10-14T02:50:52","modified_gmt":"2024-10-13T19:50:52","slug":"liver-inflammation-linked-to-cognitive-decline-in-aging","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=113888","title":{"rendered":"Liver Inflammation Linked to Cognitive Decline in Aging"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>New research explores how chronic liver inflammation may lead to brain inflammation and cognitive decline as people age. Through the study of necroptosis, a form of cell death that triggers inflammation, researchers are examining how inflammatory molecules released by the liver impact the brain. Early findings suggest that blocking necroptosis reduces liver and brain inflammation, potentially helping to maintain cognitive function.<\/p>\n<p>The study could lead to better treatments for liver and brain-related aging issues by reducing chronic inflammation. Obesity, a significant factor in inflammation, further complicates the potential impact on liver and brain health. These findings highlight the importance of understanding liver-brain communication for aging-related diseases.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Chronic liver inflammation may contribute to cognitive decline by triggering brain inflammation.<\/li>\n<li>Blocking necroptosis in the liver reduces inflammation in both the liver and brain.<\/li>\n<li>Obesity can exacerbate inflammation, increasing the risk of liver and brain diseases in aging.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Oklahoma<\/p>\n<p><strong>As people age, the liver is among several organs that experience chronic, low-grade inflammation, a state that keeps the immune system activated even though there is no threat.<\/strong><\/p>\n<p>Liver inflammation has been linked to several liver diseases, such as fatty liver disease and liver cancer, but the liver also communicates with the brain, triggering inflammation that can lead to cognitive decline. University of Oklahoma researcher Deepa Sathyaseelan, Ph.D., recently earned a $2 million grant from the National Institutes of Health to study the reasons behind this liver-brain crosstalk and test methods of protecting both organs.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105374\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence.jpg\" alt=\"This shows an older woman.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/live-inflammation-cognition-aging-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Her findings may have wide-ranging implications for both liver disease and cognitive impairment in the aging process.  Credit: Neuroscience News<\/figcaption><\/figure>\n<p>Specifically, Sathyaseelan is studying necroptosis, which is a natural form of cell death with a downside: Cells that die through necroptosis burst and release substances that lead to inflammation. In previously published research involving an aging mouse model, Sathyaseelan and her team demonstrated the damaging effects of necroptosis in the liver, as well as the reduction of those effects when necroptosis was blocked.<\/p>\n<p>They also found that activating necroptosis in the liver increased liver inflammation and, surprisingly, increased brain inflammation, which affected the mice\u2019s ability to build nests, a possible sign of cognitive impairment.<\/p>\n<p>On the strength of those studies, she earned this new NIH grant to better understand how necroptosis of liver cells causes the inflammation that affects both the liver and the brain with age. Such knowledge is crucial for ultimately devising a way to reduce inflammation and improve tissue function.<\/p>\n<p>\u201cWe hypothesize that when liver necroptosis is activated, the liver secretes toxic or inflammatory molecules that enter the bloodstream and cross the blood-brain barrier, where they cause inflammation in the brain,\u201d she said.<\/p>\n<p>\u201cThis type of organ crosstalk is becoming very important in research. Usually, when we study a disease condition, we focus on one organ, but when we do that, we miss the systemic effect.<\/p>\n<p>\u201cThis study tells us that, with age-associated cognitive decline or Alzheimer\u2019s disease, we shouldn\u2019t think only about targeting the brain. We also need to think about how liver inflammation plays a role,\u201d said Sathyaseelan, an assistant professor of biochemistry and physiology at the OU College of Medicine. She is also a research member of OU Health Stephenson Cancer Center and a researcher in the Center for Geroscience and Healthy Brain Aging.<\/p>\n<p>Sathyaseelan will investigate several additional inflammation-related factors in her study. Macrophages are immune cells that function positively during infections or injuries by \u201ceating\u201d dead cells, thereby boosting the body\u2019s ability to heal.<\/p>\n<p>However, when chronic inflammation puts the body in a constant state of alert, macrophage behavior becomes strange and further contributes to inflammation.<\/p>\n<p>She will also delve into the role of cellular senescence in liver inflammation. Senescent cells are essentially in limbo \u2013 they are no longer replicating, but neither do they die off. Senescence can be positive if, for example, it stops the cell\u2019s transformation into a cancer cell. But senescent cells also increase inflammation.<\/p>\n<p>Sathyaseelan will study the role of necroptosis on both macrophages and cellular senescence and will seek to reduce inflammation using compounds known to inhibit necroptosis.<\/p>\n<p>Her findings may have wide-ranging implications for both liver disease and cognitive impairment in the aging process. Few treatments are available for conditions like fatty liver disease and liver cancer, and older adults often are not candidates for liver transplants. In the brain, the longer that increased inflammation persists, the higher the likelihood that mild cognitive impairment will turn into severe cognitive dysfunction. Complicating the outlook for both conditions is the prevalence of obesity, another significant cause of inflammation in the body.<\/p>\n<p>\u201cWhat we have found in our mice studies so far matches what is reported for patients \u2013 that people with liver diseases have high inflammation in the liver and also have cognitive issues,\u201d Sathyaseelan said.<\/p>\n<p>\u201cOur key question is what is causing this increase in inflammation in aging? It is important that we advance our knowledge in this area because it is critical that we develop new ways to treat these diseases.\u201d<\/p>\n<p><strong>Funding:<\/strong><\/p>\n<p>The research reported in this news release is supported by the National Institute on Aging, a component of the National Institutes of Health, under award number 2R01AG059718-06A1.<\/p>\n<p>The content of this news release is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Oklahoma City-based Presbyterian Health Foundation also supported this research.<\/p>\n<p>Co-investigators for the grant are Veronica Galvan Hart, Ph.D., a professor of biochemistry and physiology at the OU College of Medicine and co-director of the Center for Geroscience and Healthy Brain Aging, and Willard Freeman, Ph.D., a researcher at the Oklahoma Medical Research Foundation. OMRF researcher Benjamin Miller, Ph.D., is also a collaborator.<\/p>\n<h2 class=\"wp-block-heading\">About this inflammation and cognitive decline research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#21405153484d0c4b0c56484d4a4453524e4f614e544952420f444554\" target=\"_blank\" rel=\"noreferrer noopener\">April Wilkerson<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/ouhsc.edu\" target=\"_blank\" rel=\"noreferrer noopener\">University of Oklahoma<\/a><br \/><strong>Contact: <\/strong>April Wilkerson \u2013 University of Oklahoma<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/liver-inflammation-cognitive-decline-27850\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: New research explores how chronic liver inflammation may lead to brain inflammation and cognitive decline as people age. Through the study of necroptosis, a form of cell death that &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=113888\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-113888","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/113888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=113888"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/113888\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=113888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=113888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=113888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}