{"id":114260,"date":"2024-10-15T03:14:04","date_gmt":"2024-10-14T20:14:04","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=114260"},"modified":"2024-10-15T03:14:04","modified_gmt":"2024-10-14T20:14:04","slug":"imaging-links-fewer-brain-connections-to-autism-social-challenges","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=114260","title":{"rendered":"Imaging Links Fewer Brain Connections to Autism Social Challenges"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>A recent study used PET imaging to examine synaptic connections in autistic and non-autistic adults, marking the first time this technology was applied to autism research. Findings show autistic adults have fewer synapses, or connections between brain cells, which closely relates to social and communicative differences in autism.<\/p>\n<p>The study indicates that lower synaptic density may underlie some of the challenges in social interaction and communication experienced by autistic individuals. Researchers believe these insights could guide future support and interventions for autism. This research highlights a potential physiological basis for social differences in autism.<\/p>\n<p><strong>Key Facts<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>PET imaging shows fewer brain synapses in autistic adults compared to non-autistic adults.<\/li>\n<li>Fewer synapses strongly correlate with social and communicative challenges in autism.<\/li>\n<li>This insight may shape better-targeted support strategies for autistic individuals.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Yale<\/p>\n<p><strong>New research\u00a0published\u00a0in\u00a0<em>Molecular Psychiatry<\/em>\u00a0looks at the differences in social interaction and communication observed in autistic and non-autistic adults, using positron emission tomography (PET), a type of brain imaging. <\/strong><\/p>\n<p>In the study, PET was used to directly measure the connections between brain cells (synapses).<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105416\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece.jpg\" alt=\"This shows a brain puzzle with missing pieces.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/social-behavior-asd-neuroscinece-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">\u201cIt gives us important ideas about how we might better support autistic people,\u201d says McPartland. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cThis is the first time it has been done in autism, and we learned that\u00a0autistic adults\u00a0have fewer of these synapses throughout their brains. We also learned that this was very strongly related to the social and communicative differences in autism,\u201d says James McPartland, Ph.D., Harris Professor in the Child Study Center at Yale School of Medicine.<\/p>\n<p>In this imaging study, McPartland says they also learned that the fewer synapses a person had, the more likely they were to show difficulties in social interaction and communication.<\/p>\n<p>These findings give insight as to what might be actually happening in the brain that accounts for the challenges many autistic people experience, he says.<\/p>\n<p>\u201cIt gives us important ideas about how we might better support autistic people,\u201d says McPartland.<\/p>\n<h2 class=\"wp-block-heading\">About this autism research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"https:\/\/medicine.yale.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">James McPartland<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/medicine.yale.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Yale<\/a><br \/><strong>Contact: <\/strong>James McPartland \u2013 Yale<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Closed access.<br \/>\u201c<a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02776-2\" target=\"_blank\" rel=\"noreferrer noopener\">11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults<\/a>\u201d by James McPartland et al. <em>Molecular Psychiatry<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults<\/strong><\/p>\n<p>The neural bases of autism are poorly understood at the molecular level, but evidence from animal models, genetics, post-mortem studies, and single-gene disorders implicate synaptopathology.<\/p>\n<p>Here, we use positron emission tomography (PET) to assess the density of synapses with synaptic vesicle glycoprotein 2A (SV2A) in autistic adults using\u00a0<sup>11<\/sup>C-UCB-J.<\/p>\n<p>Twelve autistic (mean (SD)\u00a0age 25 (4)\u00a0years; six males), and twenty demographically matched non-autistic individuals (26 (3)\u00a0years; eleven males) participated in a\u00a0<sup>11<\/sup>C-UCB-J PET scan. Binding potential,\u00a0<em>BP<\/em><sub>ND<\/sub>, was the primary outcome measure and computed with the centrum semiovale as the reference region.<\/p>\n<p>Partial volume correction with Iterative Yang was applied to control for possible volumetric differences. Mixed-model statistics were calculated for between-group differences.<\/p>\n<p>Relationships to clinical characteristics were evaluated based on clinician ratings of autistic features. Whole cortex synaptic density was 17% lower in the autism group (<em>p<\/em>\u2009=\u20090.01). All brain regions in autism had lower\u00a0<sup>11<\/sup>C-UCB-J\u00a0<em>BP<\/em><sub>ND<\/sub>\u00a0compared to non-autistic participants.<\/p>\n<p>This effect was evident in all brain regions implicated in autism. Significant differences were observed across multiple individual regions, including the prefrontal cortex (\u221215%,\u00a0<em>p<\/em>\u2009=\u20090.02), with differences most pronounced in gray matter (<em>p<\/em>\u2009&lt;\u20090.0001). Synaptic density was significantly associated with clinical measures across the whole cortex (<em>r<\/em>\u2009=\u20090.67,\u00a0<em>p<\/em>\u2009=\u20090.02) and multiple regions (<em>r<\/em>s\u2009=\u2009\u22120.58 to \u22120.82,\u00a0<em>p<\/em>s\u2009=\u20090.05 to &lt;0.01).<\/p>\n<p>The first in vivo investigation of synaptic density in autism with PET reveals pervasive and large-scale lower density in the cortex and across multiple brain areas. Synaptic density also correlated with clinical features, such that a greater number of autistic features were associated with lower synaptic density.<\/p>\n<p>These results indicate that brain-wide synaptic density may represent an as-yet-undiscovered molecular basis for the clinical phenotype of autism and associated pervasive alterations across a diversity of neural processes.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/asd-social-brain-connections-27861\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A recent study used PET imaging to examine synaptic connections in autistic and non-autistic adults, marking the first time this technology was applied to autism research. Findings show autistic &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=114260\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-114260","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/114260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=114260"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/114260\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=114260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=114260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=114260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}