{"id":115430,"date":"2024-10-18T04:28:04","date_gmt":"2024-10-17T21:28:04","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=115430"},"modified":"2024-10-18T04:28:04","modified_gmt":"2024-10-17T21:28:04","slug":"chemical-mixtures-in-blood-show-additive-neurotoxic-effects","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=115430","title":{"rendered":"Chemical Mixtures in Blood Show Additive Neurotoxic Effects"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>A new study has found that even low concentrations of chemicals, when mixed, can have cumulative neurotoxic effects on human cells. Using blood samples from a cohort of pregnant women, researchers identified and analyzed the presence of over 300 chemicals.<\/p>\n<p>Testing these chemical mixtures revealed that they could impact nerve-like cells, supporting the concept that the combined effects of chemicals add up in complex bodily mixtures. This research suggests a need for revising chemical risk assessment, focusing on combined exposures instead of isolated chemicals.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Study found that low-level chemical mixtures can have cumulative neurotoxic effects.<\/li>\n<li>Over 300 chemicals were quantified in blood samples from pregnant women.<\/li>\n<li>Findings call for updated chemical risk assessments to consider mixture effects.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Helmholtz<\/p>\n<p><strong>\u201cIn our everyday lives, we are exposed to a wide variety of chemicals that are distributed and accumulate in our bodies. These are highly complex mixtures that can affect bodily functions and our health,\u201d says Prof Beate Escher, Head of the UFZ Department of Cell Toxicology and Professor at the University of T\u00fcbingen. <\/strong><\/p>\n<p>\u201cIt is known from environmental and water studies that the effects of chemicals add up when they occur in low concentrations in complex mixtures. Whether this is also the case in the human body has not yet been sufficiently investigated \u2013 this is precisely where our study comes in.\u201d<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105474\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince.jpg\" alt=\"This shows the outline of a person.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/neurotoxic-chemicals-blood-neurosiceince-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\"> The researchers first analysed the individual mixtures of chemicals present in these samples. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The extensive research work was based on over 600 blood samples from pregnant women from the Leipzig mother-child cohort\u00a0LiNA, which has been coordinated by the UFZ since 2006. The researchers first analysed the individual mixtures of chemicals present in these samples.<\/p>\n<p>\u201cWe wanted to find out which chemicals were contained in the blood plasma and in what concentrations. We used a two-step extraction process to isolate as diverse chemical mixtures as possible,\u201d says Georg Braun, postdoctoral researcher in Beate Escher\u2019s working group and first author of the study.<\/p>\n<p>\u201cUsing mass spectrometry analyses, we searched for 1,000 different chemicals that we knew could occur in the environment, could potentially be ingested by humans and could be relevant for adverse human health effects. Of these, we were able to quantify around 300 chemicals in several plasma samples.\u201d<\/p>\n<p>This provided the researchers with information on the composition and concentration ratios of the chemical mixtures present in the 600 individual plasma samples.<\/p>\n<p>The researchers used a prediction model to calculate the neurotoxic effects of the chemical mixtures. To test the predictions of the mixture effects experimentally, they used an established cellular bioassay based on human cells that indicates neurotoxic effects.<\/p>\n<p>\u201cWe analysed individual chemicals as well as around 80 different, self-produced chemical mixtures in realistic concentration ratios. The extracts of the plasma samples were also tested,\u201d says Georg Braun.<\/p>\n<p>The results were clear.<\/p>\n<p>\u201cThe laboratory experiments confirmed the predictions from the model: the effects of the chemicals add up in complex mixtures,\u201d says environmental toxicologist Beate Escher.<\/p>\n<p>\u201cEven if the individual concentrations of neurotoxic chemicals are so low that they are each below the effect threshold, there is still an effect on nerve-like cells in complex mixtures with many other chemicals.\u201d<\/p>\n<p>But what exactly do these results mean?<\/p>\n<p>\u201cWith our study, we were able to prove for the first time that what is known about the effects of chemical mixtures in the environment also applies to humans,\u201d says Escher.<\/p>\n<p>\u201cIt is therefore imperative that we rethink risk assessment. Indicator substances alone are far from sufficient. In future, we must learn to think in terms of mixtures.\u201d<\/p>\n<p>UFZ environmental immunologist and head of the LiNA study Dr Gunda Herberth adds: \u201cIt is becoming increasingly clear that many diseases such as allergies, immune system disorders, obesity or the development of the nervous system are linked to exposure to chemicals in the womb or in early childhood.\u201d<\/p>\n<p>The test method presented in this study \u2013 the extraction of chemical mixtures from human samples and their characterisation using chemical analysis combined with cell-based biotest systems \u2013 opens up new possibilities for researching the effects of complex chemical mixtures on human health.<\/p>\n<p>In future research projects, the scientists want to refine their test method and investigate the effects of chemical mixtures on other health-relevant endpoints such as immunotoxicity.<\/p>\n<p>In addition, they would like to uncover possible links between chemical exposure and the development of developmental disorders in children.<\/p>\n<p>As members of the German Centre for Child and Adolescent Health, a Germany-wide research network of university hospitals, universities and non-university research institutions, the UFZ researchers will work with numerous experts from the fields of medicine and epidemiology in the future in order to apply these methods of effect-based human biomonitoring in practice.<\/p>\n<h2 class=\"wp-block-heading\">About this environmental neuroscience research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#93e0e6e0f2fdfdf6bdfbe6f5f6d3e6f5e9bdf7f6\" target=\"_blank\" rel=\"noreferrer noopener\">Susanne Hufe<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/ufz.de\" target=\"_blank\" rel=\"noreferrer noopener\">Helmholtz<\/a><br \/><strong>Contact: <\/strong>Susanne Hufe \u2013 Helmholtz<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adq0336\" target=\"_blank\" rel=\"noreferrer noopener\">Neurotoxic mixture effects of chemicals extracted from blood of pregnant women<\/a>\u201d by Beate Escher et al. <em>Science<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Neurotoxic mixture effects of chemicals extracted from blood of pregnant women<\/strong><\/p>\n<p>Human biomonitoring studies typically capture only a small and unknown fraction of the entire chemical universe.<\/p>\n<p>We combined chemical analysis with a high-throughput in vitro assay for neurotoxicity to capture complex mixtures of organic chemicals in blood.<\/p>\n<p>Plasma samples of 624 pregnant women from the German LiNA cohort were extracted with a nonselective extraction method for organic chemicals. 294 of &gt;1000 target analytes were detected and quantified. Many of the detected chemicals as well as the whole extracts interfered with neurite development.<\/p>\n<p>Experimental testing of simulated complex mixtures of detected chemicals in the neurotoxicity assay confirmed additive mixture effects at concentrations less than individual chemicals\u2019 effect thresholds.<\/p>\n<p>The use of high-throughput target screening combined with bioassays has the potential to improve human biomonitoring and provide a new approach to including mixture effects in epidemiological studies.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/chemicals-neurotoxic-blood-27876\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A new study has found that even low concentrations of chemicals, when mixed, can have cumulative neurotoxic effects on human cells. Using blood samples from a cohort of pregnant &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=115430\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-115430","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/115430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=115430"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/115430\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=115430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=115430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=115430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}