{"id":115783,"date":"2024-10-19T02:32:47","date_gmt":"2024-10-18T19:32:47","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=115783"},"modified":"2024-10-19T02:32:47","modified_gmt":"2024-10-18T19:32:47","slug":"key-enzyme-found-to-drive-inflammation-in-aging-cells","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=115783","title":{"rendered":"Key Enzyme Found to Drive Inflammation in Aging Cells"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers have discovered that the enzyme ATP-citrate lyase (ACLY) plays a critical role in driving the inflammatory process linked to aging, known as the senescence-associated secretory phenotype (SASP). The study shows that blocking ACLY can reduce the expression of inflammation-related genes in aging cells, opening the door for potential therapies to combat age-related diseases like dementia and atherosclerosis.<\/p>\n<p> By inhibiting ACLY, researchers were able to suppress chronic inflammation in aged mice, offering a promising new strategy for extending healthy lifespans. This breakthrough could lead to treatments that specifically target the damaging aspects of aging without eliminating aging cells.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>ACLY enzyme drives inflammation in aging cells by activating inflammatory genes.<\/li>\n<li>Inhibiting ACLY reduced inflammation-related gene expression in aged mice.<\/li>\n<li>Targeting the ACLY-BRD4 pathway may promote healthy aging by controlling inflammation.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Kumamoto University<\/p>\n<p><strong>A team at Kumamoto University has made a groundbreaking discovery in the field of aging and inflammation. Japan\u2019s aging population is growing at an unprecedented rate, making it crucial to extend healthy lifespans rather than just lifespans. <\/strong><\/p>\n<p>The research focuses on \u201ccellular senescence,\u201d a process where cells stop dividing and enter a state associated with chronic inflammation and aging.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105516\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence.jpg\" alt=\"This shows cells.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/inflammation-enzyme-aging-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Furthermore, the study revealed that ACLY-derived acetyl-CoA modifies histones, proteins that DNA wraps around, allowing the chromatin reader BRD4 to activate inflammatory genes. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>This cellular state, known as the senescence-associated secretory phenotype (SASP), involves the secretion of inflammatory proteins that accelerate aging and disease, such as dementia, diabetes, and atherosclerosis.<\/p>\n<p>The researchers found that ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, plays a critical role in activating SASP. This discovery was made using advanced sequencing and bioinformatics analyses on human fibroblasts, a type of cell found throughout the body.<\/p>\n<p>They demonstrated that blocking ACLY activity, either genetically or with inhibitors, significantly reduced the expression of inflammation-related genes in aging cells. This suggests that ACLY is a crucial factor in maintaining the pro-inflammatory environment in aged tissues.<\/p>\n<p>Furthermore, the study revealed that ACLY-derived acetyl-CoA modifies histones, proteins that DNA wraps around, allowing the chromatin reader BRD4 to activate inflammatory genes.<\/p>\n<p>By targeting the ACLY-BRD4 pathway, the researchers were able to suppress inflammation responses in aged mice, highlighting the potential of ACLY inhibitors in controlling chronic inflammation while maintaining healthy aging.<\/p>\n<p>This discovery opens new avenues for developing treatments that specifically target the harmful aspects of aging cells without removing them, offering a promising strategy for managing aging and age-related diseases.<\/p>\n<p>The research provides a stepping stone toward therapies that can control cellular aging, promoting longer, healthier lives.<\/p>\n<h2 class=\"wp-block-heading\">About this inflammation and aging research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author:<\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#95e7f0e6f0f4e7f6fdb8f6fafae7f1fcfbf4e1fae7d5fffcf8e0bbfee0f8f4f8fae1fab8e0bbf4f6bbffe5\" target=\"_blank\" rel=\"noreferrer noopener\"><strong> <\/strong>Nuo LI<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/kumamoto-u.ac.jp\" target=\"_blank\" rel=\"noreferrer noopener\">Kumamoto University<\/a><br \/><strong>Contact: <\/strong>Nuo LI \u2013 Kumamoto University<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00825-8\" target=\"_blank\" rel=\"noreferrer noopener\">Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers<\/a>\u201d by Kan\u00a0Etoh et al. <em>Cell Reports<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers<\/strong><\/p>\n<p>The senescent microenvironment and aged cells per se contribute to tissue remodeling, chronic inflammation, and age-associated dysfunction. However, the metabolic and epigenomic bases of the senescence-associated secretory phenotype (SASP) remain largely unknown.<\/p>\n<p>Here, we show that ATP-citrate lyase (ACLY), a key enzyme in acetyl-coenzyme A (CoA) synthesis, is essential for the pro-inflammatory SASP, independent of persistent growth arrest in senescent cells.<\/p>\n<p>Citrate-derived acetyl-CoA facilitates the action of SASP gene enhancers. ACLY-dependent\u00a0<em>de novo<\/em>\u00a0enhancers augment the recruitment of the chromatin reader BRD4, which causes SASP activation.<\/p>\n<p>Consistently, specific inhibitions of the ACLY-BRD4 axis suppress the STAT1-mediated interferon response, creating the pro-inflammatory microenvironment in senescent cells and tissues.<\/p>\n<p>Our results demonstrate that ACLY-dependent citrate metabolism represents a selective target for controlling SASP designed to promote healthy aging.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/acyl-inflammation-cell-aging-27885\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers have discovered that the enzyme ATP-citrate lyase (ACLY) plays a critical role in driving the inflammatory process linked to aging, known as the senescence-associated secretory phenotype (SASP). The &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=115783\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8628],"tags":[],"class_list":["post-115783","post","type-post","status-publish","format-standard","hentry","category-science","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/115783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=115783"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/115783\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=115783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=115783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=115783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}