{"id":116943,"date":"2024-10-22T05:02:46","date_gmt":"2024-10-21T22:02:46","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=116943"},"modified":"2024-10-22T05:02:46","modified_gmt":"2024-10-21T22:02:46","slug":"vitamin-d-deficiency-in-childhood-linked-to-higher-autoimmune-risk","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=116943","title":{"rendered":"Vitamin D Deficiency in Childhood Linked to Higher Autoimmune Risk"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>A recent study found that vitamin D deficiency during childhood accelerates the aging of the thymus, a crucial organ in training immune cells. As the thymus ages, it becomes less effective at filtering out cells that could mistakenly attack the body\u2019s own tissues, increasing the risk of autoimmune diseases like type 1 diabetes.<\/p>\n<p>This research highlights the importance of ensuring children get adequate vitamin D, especially during the \u201cvitamin D winter\u201d months when sunlight can\u2019t provide enough. The findings could inform new strategies to prevent autoimmune conditions by focusing on early vitamin D intake.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>Vitamin D deficiency in childhood speeds up thymus aging, raising autoimmune risk.<\/li>\n<li>An aged thymus can lead to a \u201cleaky\u201d immune system, increasing disease susceptibility.<\/li>\n<li>Vitamin D supplementation, especially in winter months, is essential for immune health.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>McGill University<\/p>\n<p><strong>As Canadians brace for \u201cvitamin D winter\u201d\u2014months when the sun\u2019s angle is too low to produce the vitamin in the skin\u2014a McGill University study explains why vitamin D deficiency early in life is associated with a higher risk of autoimmune diseases.<\/strong><\/p>\n<p>During childhood, the thymus helps train\u00a0immune cells\u00a0to distinguish between the body\u2019s own tissues and harmful invaders. A vitamin D deficiency at that stage of life causes the thymus to age more quickly, the researchers discovered.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105579\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence.jpg\" alt=\"This shows a child standing in the sunshine.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/vitamin-d-autoimmune-disease-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">It found that children who were supplemented early in life with vitamin D had up to a five-fold-lower risk of developing type 1 diabetes later in life. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The study is\u00a0published\u00a0in the journal\u00a0<em>Science Advances<\/em>.<\/p>\n<p>\u201cAn aging thymus leads to a \u2018leaky\u2019 immune system,\u201d said lead author John White, a Professor in and Chair of McGill\u2019s Department of Physiology.<\/p>\n<p>\u201cThis means the thymus becomes less effective at filtering out immune cells that could mistakenly attack healthy tissues, increasing the risk of autoimmune diseases like type 1 diabetes.\u201d<\/p>\n<p>He noted that researchers have known for years that vitamin D helps the body absorb calcium for strong bones, and that more recent research has discovered its crucial role in regulating the immune system.<\/p>\n<p>\u201cOur findings bring new clarity to this connection and could lead to new strategies for preventing autoimmune diseases,\u201d he said.<\/p>\n<p>Although the research was conducted with mice, the findings are relevant to human health because the thymus functions similarly in both species, White added.<\/p>\n<h2 class=\"wp-block-heading\">The importance of a sunlight substitute<\/h2>\n<p>The findings highlight the importance of adequate vitamin D intake, especially for children.<\/p>\n<p>\u201cIn places like Montreal, where we stop making the vitamin from sunlight between late fall and\u00a0early spring, supplementation is key,\u201d said White.<\/p>\n<p>\u201cIf you have a\u00a0young child, it\u2019s important to consult with your health-care provider to ensure they\u2019re getting enough.\u201d<\/p>\n<p>The breakthrough builds on a 2001 Finnish study, which followed more than 10,000 children. It found that children who were supplemented early in life with vitamin D had up to a five-fold-lower risk of developing type 1 diabetes later in life.<\/p>\n<p>Finland, with its long periods of vitamin D winter, served as an ideal case study to learn more about the nutrient\u2019s many roles, said White.<\/p>\n<p>In the McGill study, researchers used mice that couldn\u2019t produce vitamin D to examine how the deficiency affected the thymus, employing cell analysis and gene sequencing to see how it impacts the immune system.<\/p>\n<p>In future studies, White hopes to explore how vitamin D affects the human\u00a0thymus, something he notes has not been done before.<\/p>\n<h2 class=\"wp-block-heading\">About this neurology research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/www.mcgill.ca\/\" target=\"_blank\" rel=\"noreferrer noopener\">Keila DePape<\/a><br \/><strong>Source: <\/strong><a href=\"http:\/\/www.mcgill.ca\/\" target=\"_blank\" rel=\"noreferrer noopener\">McGill University<\/a><br \/><strong>Contact: <\/strong>Keila DePape \u2013 McGill University<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adm9582\" target=\"_blank\" rel=\"noreferrer noopener\">Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling<\/a>\u201d by Patricio Artusa et al. <em>Science Advances<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling<\/strong><\/p>\n<p>Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression.<\/p>\n<p>Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between vitamin D deficiency and autoimmunity. We find that mice lacking Cyp27b1, which cannot produce hormonally active vitamin D, display profoundly reduced thymic cellularity, with a reduced proportion of Aire<sup>+<\/sup>\u00a0mTECs, attenuated TRA expression, and poorly defined cortical-medullary boundaries.<\/p>\n<p>Markers of T cell negative selection are diminished, and organ-specific autoantibodies are present in knockout (KO) mice. Single-cell RNA sequencing revealed that loss of Cyp27b1 skews mTEC differentiation toward Ccl21<sup>+<\/sup>\u00a0intertypical TECs and generates a gene expression profile consistent with premature aging. KO thymi display accelerated involution and reduced expression of thymic longevity factors.<\/p>\n<p>Thus, loss of thymic vitamin D signaling disrupts normal mTEC differentiation and function and accelerates thymic aging.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/vitamin-d-autoimmune-disease-27903\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A recent study found that vitamin D deficiency during childhood accelerates the aging of the thymus, a crucial organ in training immune cells. As the thymus ages, it becomes &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=116943\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-116943","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/116943","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=116943"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/116943\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=116943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=116943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=116943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}