{"id":117326,"date":"2024-10-23T05:28:45","date_gmt":"2024-10-22T22:28:45","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=117326"},"modified":"2024-10-23T05:28:45","modified_gmt":"2024-10-22T22:28:45","slug":"zombie-aging-cells-may-speed-up-brain-decline","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=117326","title":{"rendered":"&#8220;Zombie&#8221; Aging Cells May Speed Up Brain Decline"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Recent research shows that senescent, or \u201czombie,\u201d skin cells may accelerate aging throughout the body. When transplanted into a preclinical model, these cells caused senescence to spread to other organs, impairing muscle function and brain health.<\/p>\n<p>This discovery suggests that skin aging could drive broader systemic aging, offering new insights into the connection between skin conditions and overall decline. The study supports anti-aging strategies that address both physical and cognitive health by targeting senescent cells.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>Senescent skin cells can accelerate aging in other organs and systems.<\/li>\n<li>The spread of these cells impairs muscle function and brain health.<\/li>\n<li>The research supports anti-aging approaches that target senescent cells in the skin.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Mayo Clinic<\/p>\n<p><strong>Mayo Clinic researchers have found that senescent cells\u2014non-dividing \u201czombie\u201d cells\u2014accumulate in the skin as people age and may influence aging in other parts of the body.<\/strong><\/p>\n<p>Their recent study revealed that transplanting senescent skin cells into a preclinical model revealed that they not only caused that senescence to spread to other tissues but also accelerated physical decline, impaired muscle function and adversely affected brain health. This discovery indicates that senescent cells in the skin could drive broader, systemic aging.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105642\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience.jpg\" alt=\"This shows an older man.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/10\/zombie-cells-brain-decline-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">This research also offers support for anti-aging strategies that aim to keep both the body and mind healthier for longer. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cThis discovery is significant because it suggests that senescent cells in the skin\u2014an organ not typically associated with aging, beyond wrinkles\u2014might be driving broader, systemic aging processes.<\/p>\n<p>\u201cThese findings could also help explain the link between\u00a0skin conditions\u00a0and\u00a0cognitive decline, offering potential new pathways for addressing both physical and mental deterioration as we age,\u201d says Mayo Clinic researcher Jo\u00e3o Passos, Ph.D., who is one of the lead authors on the study,\u00a0published\u00a0in\u00a0<em>Aging Cell<\/em>.<\/p>\n<p>This research also offers support for anti-aging strategies that aim to keep both the body and mind healthier for longer.<\/p>\n<p>\u201cThis study suggests that skin senescence may accelerate aging in other organs, highlighting the importance of preventing factors like\u00a0sun exposure, smoking, alcohol and\u00a0poor diet\u00a0that contribute to premature skin aging,\u201d says Ana Catarina Franco, the study\u2019s first author and Mayo Clinic visiting graduate student.<\/p>\n<p>The researchers aim to investigate whether senolytic drugs, originally developed at Mayo Clinic and shown to eliminate senescent cells among people with a high number of senescent cells, can improve overall health when applied topically to the skin.<\/p>\n<p>They also plan to do more research to try to understand the mechanisms by which\u00a0senescent cells\u00a0may spread from the skin to other organs.<\/p>\n<h2 class=\"wp-block-heading\">About this brain aging research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"https:\/\/www.mayoclinic.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ana Catarina Franco<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/www.mayoclinic.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mayo Clinic<\/a><br \/><strong>Contact: <\/strong>Ana Catarina Franco \u2013 Mayo Clinic<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acel.14340\" target=\"_blank\" rel=\"noreferrer noopener\">Senescent cell transplantation into the skin induces age\u2010related peripheral dysfunction and cognitive decline<\/a>\u201d by Ana Catarina Franco et al. <em>Aging Cell<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Senescent cell transplantation into the skin induces age\u2010related peripheral dysfunction and cognitive decline<\/strong><\/p>\n<p>Cellular senescence is an established cause of cell and tissue aging. Senescent cells have been shown to increase in multiple organs during aging, including the skin. Here we hypothesized that senescent cells residing in the skin can spread senescence to distant organs, thereby accelerating systemic aging processes.<\/p>\n<p>To explore this hypothesis, we initially observed an increase in several markers of senescence in the skin of aging mice. Subsequently, we conducted experiments wherein senescent fibroblasts were transplanted into the dermis of young mice and assessed various age-associated parameters.<\/p>\n<p>Our findings reveal that the presence of senescent cells in the dermal layer of young mice leads to increased senescence in both proximal and distal host tissues, alongside increased frailty, and impaired musculoskeletal function.<\/p>\n<p>Additionally, there was a significant decline in cognitive function, concomitant with increased expression of senescence-associated markers within the hippocampus brain area.<\/p>\n<p>These results support the concept that the accumulation of senescent cells in the skin can exert remote effects on other organs including the brain, potentially explaining links between skin and brain disorders and diseases and, contributing to physical and cognitive decline associated with aging.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/zombie-cells-brain-aging-27919\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Recent research shows that senescent, or \u201czombie,\u201d skin cells may accelerate aging throughout the body. When transplanted into a preclinical model, these cells caused senescence to spread to other &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=117326\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-117326","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/117326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=117326"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/117326\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=117326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=117326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=117326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}