{"id":117516,"date":"2024-10-23T17:40:49","date_gmt":"2024-10-23T10:40:49","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=117516"},"modified":"2024-10-23T17:40:49","modified_gmt":"2024-10-23T10:40:49","slug":"what-drugmakers-did-not-tell-volunteers-in-alzheimers-trials","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=117516","title":{"rendered":"What Drugmakers Did Not Tell Volunteers in Alzheimer\u2019s Trials"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div data-testid=\"companionColumn-0\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">By 2021, nearly 2,000 volunteers had answered the call to test an experimental Alzheimer\u2019s drug known as BAN2401. For the drugmaker Eisai, the trial was a shot at a windfall \u2014 potentially billions of dollars \u2014 for defanging a disease that had confounded researchers for more than a century.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">To assess the drug\u2019s effectiveness and safety, Eisai sought to include people whose genetic profiles made them especially prone to develop Alzheimer\u2019s. But these same people were also more vulnerable to brain bleeding or swelling if they received the drug.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">To identify these high-risk volunteers, Eisai told everyone that they would be given a genetic test. But the results, the company added, would remain secret.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In all, 274 volunteers joined the trial without Eisai telling them they were at an especially high risk for brain injuries, documents obtained by The New York Times show.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div data-testid=\"companionColumn-1\">\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">One of them was Genevieve Lane, a 79-year-old resident of the Villages in Florida who died in September 2022 after three doses of the drug, her brain riddled with 51 microhemorrhages. An autopsy determined that the drug\u2019s side effects had contributed to her death. Her final hours were spent thrashing so violently that nurses had to tie her down.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Another high-risk trial volunteer died, and more than 100 others suffered brain bleeding or swelling. While most of those injuries were mild and asymptomatic, some were serious and life-threatening.<\/p>\n<div class=\"css-1336jj\">\n<div class=\"css-121kum4\">\n<div class=\"css-asuuk5\"><noscript><\/p>\n<div class=\"css-7axq9l\" data-testid=\"optimistic-truncator-noscript\"><svg width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" aria-hidden=\"true\" class=\"css-1b5b8u1\"><path fill=\"currentColor\" fill-rule=\"evenodd\" d=\"M2.5 12a9.5 9.5 0 1 1 19 0 9.5 9.5 0 0 1-19 0Zm8.5 1.75v-7.5h2v7.5h-2Zm0 2v2h2v-2h-2Z\" clip-rule=\"evenodd\"\/><\/svg><\/p>\n<div data-testid=\"optimistic-truncator-noscript-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">We are having trouble retrieving the article content.<\/p>\n<p class=\"css-3kpklk\">Please enable JavaScript in your browser settings.<\/p>\n<\/div>\n<\/div>\n<p><\/noscript><\/p>\n<div class=\"css-1dv1kvn\" id=\"optimistic-truncator-a11y\" tabindex=\"-1\">\n<hr\/>\n<p>Thank you for your patience while we verify access. If you are in Reader mode please exit and\u00a0<a href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F10%2F23%2Fhealth%2Falzheimers-drug-brain-bleeding.html&amp;asset=opttrunc\">log into<\/a>\u00a0your Times account, or\u00a0<a href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F10%2F23%2Fhealth%2Falzheimers-drug-brain-bleeding.html\">subscribe<\/a>\u00a0for all of The Times.<\/p>\n<hr\/>\n<\/div>\n<div class=\"css-1g71tqy\"><svg width=\"24\" height=\"24\" viewbox=\"0 0 24 24\" aria-hidden=\"true\" class=\"css-63woee\" data-testid=\"optimistic-truncator-spinner\"><g fill=\"currentColor\"><path d=\"M11.28 22.8a.72.72 0 1 0 1.44 0v-6.72a.72.72 0 1 0-1.44 0v6.72Z\" opacity=\".37\"\/><path d=\"M17.766 21.16a.72.72 0 1 0 1.165-.846l-3.95-5.436a.72.72 0 1 0-1.165.846l3.95 5.437Z\" opacity=\".26\"\/><path d=\"M1.506 14.653a.72.72 0 0 0 .445 1.37l6.391-2.078a.72.72 0 1 0-.445-1.369l-6.39 2.077Z\" opacity=\".61\"\/><path d=\"M5.07 20.314a.72.72 0 0 0 1.164.847l3.95-5.437a.72.72 0 1 0-1.165-.846l-3.95 5.436Z\" opacity=\".48\"\/><path d=\"M22.049 16.022a.72.72 0 0 0 .445-1.37l-6.391-2.076a.72.72 0 1 0-.445 1.37l6.39 2.076Z\" opacity=\".17\"\/><path d=\"M22.494 9.347a.72.72 0 1 0-.445-1.37l-6.391 2.078a.72.72 0 1 0 .445 1.369l6.39-2.077Z\" opacity=\".09\"\/><path d=\"M6.234 2.84a.72.72 0 0 0-1.165.846l3.95 5.436a.72.72 0 0 0 1.165-.846l-3.95-5.437Z\" opacity=\".87\"\/><path d=\"M1.951 7.978a.72.72 0 1 0-.445 1.37l6.391 2.076a.72.72 0 1 0 .445-1.37l-6.39-2.076Z\" opacity=\".74\"\/><path d=\"M18.93 3.686a.72.72 0 0 0-1.164-.847l-3.95 5.437a.72.72 0 0 0 1.165.846l3.95-5.436Z\" opacity=\".02\"\/><path d=\"M12.72 1.2a.72.72 0 1 0-1.44 0v6.72a.72.72 0 0 0 1.44 0V1.2Z\"\/><\/g><\/svg><\/p>\n<div data-testid=\"optimistic-truncator-message\" class=\"css-6yo1no\">\n<p class=\"css-3kpklk\">Thank you for your patience while we verify access.<\/p>\n<p class=\"css-3kpklk\">Already a subscriber?\u00a0<a data-testid=\"log-in-link\" class=\"css-z5ryv4\" href=\"https:\/\/myaccount.nytimes.com\/auth\/login?response_type=cookie&amp;client_id=vi&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F10%2F23%2Fhealth%2Falzheimers-drug-brain-bleeding.html&amp;asset=opttrunc\">Log in<\/a>.<\/p>\n<p class=\"css-3kpklk\">Want all of The Times?\u00a0<a data-testid=\"subscribe-link\" class=\"css-z5ryv4\" href=\"https:\/\/www.nytimes.com\/subscription?campaignId=89WYR&amp;redirect_uri=https%3A%2F%2Fwww.nytimes.com%2F2024%2F10%2F23%2Fhealth%2Falzheimers-drug-brain-bleeding.html\">Subscribe<\/a>.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2024\/10\/23\/health\/alzheimers-drug-brain-bleeding.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>By 2021, nearly 2,000 volunteers had answered the call to test an experimental Alzheimer\u2019s drug known as BAN2401. For the drugmaker Eisai, the trial was a shot at a windfall &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=117516\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-117516","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/117516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=117516"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/117516\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=117516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=117516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=117516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}