{"id":117874,"date":"2024-10-24T16:03:52","date_gmt":"2024-10-24T09:03:52","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=117874"},"modified":"2024-10-24T16:03:52","modified_gmt":"2024-10-24T09:03:52","slug":"repeated-covid-vaccinations-found-to-enhance-mucosal-immunity-against-the-virus","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=117874","title":{"rendered":"Repeated COVID vaccinations found to enhance mucosal immunity against the virus"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<div class=\"article-gallery lightGallery\">\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2021\/sarscov2covi.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/2021\/sarscov2covi.jpg\" data-sub-html=\"Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: National Institute of Allergy and Infectious Diseases, NIH\">\n<figure class=\"article-img\">\n            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2021\/sarscov2covi.jpg\" alt=\"SARS-CoV-2 , COVID-19\" title=\"Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: National Institute of Allergy and Infectious Diseases, NIH\" width=\"799\" height=\"530\"\/><figcaption class=\"text-darken text-low-up text-truncate-js text-truncate mt-3\">\n                Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, isolated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: National Institute of Allergy and Infectious Diseases, NIH<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<\/div>\n<p>During the COVID pandemic, many of us received multiple mRNA vaccines. New work by researchers at the VIB-UGent Center for Inflammation Research, Ghent University, and University Hospital Ghent, among others, has found that such repeated vaccinations lead to the presence of mucosal antibodies, for example, inside the nose. Their work <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adn2364\" target=\"_blank\" rel=\"noopener\">appears<\/a> in <i>Science Translational Medicine.<\/i><\/p>\n<p>Part of the global response strategy against the COVID pandemic involves the administration of booster shots, or vaccine updates, to ensure protection against new variants of the SARS-CoV-2 virus.<\/p>\n<p>The researchers set out to investigate the effects of multiple mRNA vaccines on mucosal immunity, referring to <a href=\"https:\/\/medicalxpress.com\/tags\/mucous+membranes\/\" rel=\"tag\" class=\"textTag\">mucous membranes<\/a> such as the ones on the inside of our noses. Specifically, the research involved a cohort of 183 participants who were sampled at multiple time points after primary and booster vaccinations.<\/p>\n<p>Ph.D. student Jozefien Declercq (VIB-UGent) explains, &#8220;We found that individuals who received multiple doses of mRNA vaccines exhibited a marked increase in neutralizing antibodies in nasal secretions, which are essential for blocking viral entry. Not only that, but the immune responses generated by mRNA vaccines may persist longer than previously thought, which provides hope for sustained protection against emerging variants of the virus.&#8221;<\/p>\n<h2>From the blood to the nose<\/h2>\n<p>How do the antibodies produced in response to the vaccine get to the nose, though?<\/p>\n<p>Prof. Dr. Stijn Vanhee (VIB-UGent), co-senior author of the study, explains. &#8220;Using a <a href=\"https:\/\/medicalxpress.com\/tags\/mouse+model\/\" rel=\"tag\" class=\"textTag\">mouse model<\/a>, we discovered that most mucosal neutralizing antibodies were of systemic origin, with antibodies circulating in the blood migrating to the respiratory mucosa in the nose, suggesting that repeated vaccination stimulates systemic antibody production that can reach mucosal membranes.&#8221;<\/p>\n<p>The findings suggest that repeated vaccinations not only bolster systemic immunity but also enhance mucosal antibody responses, providing a more robust defense against the virus.<\/p>\n<p>Prof. Dr. Linos Vandekerckhove (Ghent University), co-senior author of the study, emphasizes the critical role of mucosal immunity in the fight against COVID-19: &#8220;Our study provides compelling evidence that repeated mRNA <a href=\"https:\/\/medicalxpress.com\/tags\/vaccinations\/\" rel=\"tag\" class=\"textTag\">vaccinations<\/a> can improve mucosal antibody responses, or stimulate pre-existing infection induced mucosal responses, which are vital for preventing infection at the entry points of the virus. This could have <a href=\"https:\/\/medicalxpress.com\/tags\/profound+implications\/\" rel=\"tag\" class=\"textTag\">profound implications<\/a> for <a href=\"https:\/\/medicalxpress.com\/tags\/public+health+strategies\/\" rel=\"tag\" class=\"textTag\">public health strategies<\/a> moving forward, especially as we face new variants of concern.&#8221;<\/p>\n<div class=\"article-main__more p-4\">\n<p><strong>More information:<\/strong><br \/>\n                                                    Jozefien Declercq et al, Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa, <i>Science Translational Medicine<\/i> (2024). <a data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1126\/scitranslmed.adn2364\" target=\"_blank\" rel=\"noopener\">DOI: 10.1126\/scitranslmed.adn2364<\/a>. <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adn2364\" target=\"_blank\" rel=\"noopener\">www.science.org\/doi\/10.1126\/scitranslmed.adn2364<\/a><\/p>\n<\/p><\/div>\n<div class=\"d-inline-block text-medium my-4\">\n\t\t\t\t\t\t\t\t\t\t\t\tProvided by<br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/medicalxpress.com\/partners\/vib--the-flanders-institute-for-biotechnology-\/\">VIB (the Flanders Institute for Biotechnology)<\/a><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"icon_open\" href=\"http:\/\/www.vib.be\/VIB\/EN\/\" target=\"_blank\" rel=\"nofollow noopener\"><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<svg>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<use href=\"https:\/\/medx.b-cdn.net\/tmpl\/v6\/img\/svg\/sprite.svg#icon_open\" x=\"0\" y=\"0\"\/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/svg><br \/>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a><\/p><\/div>\n<p>                                        <!-- print only --><\/p>\n<div class=\"d-none d-print-block\">\n<p>\n                                                 <strong>Citation<\/strong>:<br \/>\n                                                 Repeated COVID vaccinations found to enhance mucosal immunity against the virus (2024, October 23)<br \/>\n                                                 retrieved 24 October 2024<br \/>\n                                                 from https:\/\/medicalxpress.com\/news\/2024-10-covid-vaccinations-mucosal-immunity-virus.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. 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Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=117874\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-117874","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/117874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=117874"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/117874\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=117874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=117874"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=117874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}