{"id":121159,"date":"2024-11-02T09:33:03","date_gmt":"2024-11-02T02:33:03","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=121159"},"modified":"2024-11-02T09:33:03","modified_gmt":"2024-11-02T02:33:03","slug":"cold-sore-viruss-path-in-brain-revealed","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=121159","title":{"rendered":"Cold Sore Virus\u2019s Path in Brain Revealed"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Research has shown that HSV-1, the virus responsible for cold sores, can spread into specific areas of the brain and may contribute to neurodegenerative diseases. Mapping HSV-1\u2019s path reveals it targets regions crucial for functions like sleep, movement, and mood regulation.<\/p>\n<p>The study also found that HSV-1 activates the brain\u2019s immune cells, causing inflammation that could persist even after the virus clears. This prolonged inflammation may be a trigger for neurological diseases.<\/p>\n<p>Understanding HSV-1\u2019s interactions in the brain could inform future treatments. The findings offer vital clues on how this common virus may play a role in the onset of diseases like Alzheimer\u2019s.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ol class=\"wp-block-list\">\n<li>HSV-1 targets brain areas like the hypothalamus, impacting mood and hormonal control.<\/li>\n<li>HSV-1 activates microglia, the brain\u2019s immune cells, causing persistent inflammation.<\/li>\n<li>Chronic inflammation from HSV-1 may lead to neurological and neurodegenerative diseases.<\/li>\n<\/ol>\n<p><strong>Source: <\/strong>University of Colorado<\/p>\n<p><strong>Herpes simplex virus type 1 (HSV-1), the cause of the common cold sore, can spread into the central nervous system and preferences for certain parts of the brain. <\/strong><\/p>\n<p>Study results published today in the\u00a0<em>Journal of Virology<\/em>\u00a0are among the first to recognize how this common virus infiltrates the brain, leading to a better understanding of how HSV-1 may trigger neurological diseases.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105832\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience.jpg\" alt=\"This shows a brain.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/hsv-1-neurology-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Researchers also found HSV-1 in regions of the brain that produce serotonin and norepinephrine, as well as the hypothalamus, a critical center of appetite, sleep, mood, and hormonal control within the brain. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cRecently, this common virus has been implicated in neurodegenerative diseases, such as Alzheimer\u2019s disease, but no clear route of central nervous system invasion has been established,\u201d says Christy Niemeyer, PhD, assistant professor of neurology at the\u00a0University of Colorado Anschutz Medical Campus\u00a0and co-first and corresponding author.<\/p>\n<p>\u201cIdentifying how HSV-1 can get into the brain and what brain regions are vulnerable is key in understanding how it initiates disease.\u201d<\/p>\n<p>Once HSV-1 enters the brain, researchers also wanted to determine if the virus migrates at random or to specific areas. They were able to map where and how the virus travels within the brain and infects critical brain regions that control many vital functions, such as the brain stem, which controls sleep and movement.<\/p>\n<p>Researchers also found HSV-1 in regions of the brain that produce serotonin and norepinephrine, as well as the hypothalamus, a critical center of appetite, sleep, mood, and hormonal control within the brain.<\/p>\n<p>\u201cEven though the presence of HSV-1 is not causing full-blown encephalitis in the brain, it can still affect how these regions function,\u201d says Niemeyer.<\/p>\n<p>Niemeyer and coauthors also show how HSV-1 interacts with the brain\u2019s key immune cells; microglia. They found that microglia became \u201cinflamed\u201d when interacting with HSV-1, but in some brain regions, inflamed microglia persisted even after the virus was no longer detected.<\/p>\n<p>\u201cIdentifying the role of microglia provides helpful clues to the consequences of HSV-1 infection, and how it triggers neurological diseases,\u201d says Niemeyer.<\/p>\n<p>\u201cPersistently inflamed cells can lead to chronic inflammation, a known trigger for a number of neurological and neurodegenerative diseases. This research offers important takeaways in better understanding how viruses interact with overall brain health as well as the onset of pervasive neurological diseases.\u201d<\/p>\n<h2 class=\"wp-block-heading\">About this neurology research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#9cf7f9f0eff9fdb2ecf5f9e8f9eeefdcffe9fdf2effff4e9e8e6b2f9f8e9\" target=\"_blank\" rel=\"noreferrer noopener\">Kelsea Pieters<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/cuanschutz.edu\" target=\"_blank\" rel=\"noreferrer noopener\">University of Colorado<\/a><br \/><strong>Contact: <\/strong>Kelsea Pieters \u2013 University of Colorado<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Closed access.<br \/>\u201c<a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.00968-24\" target=\"_blank\" rel=\"noreferrer noopener\">Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity<\/a>\u201d by Christy Niemeyer et al. <em>Journal of Virology<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity<\/strong><\/p>\n<p>Herpes simplex virus type 1 (HSV-1) primarily targets the oral and nasal epithelia before establishing latency in the trigeminal ganglion (TG) and other peripheral ganglia.<\/p>\n<p>HSV-1 can also infect and become latent in the central nervous system (CNS) independent of latency in the TGs.<\/p>\n<p>Recent studies suggest entry to the CNS via two distinct routes: the TG-brainstem connection and olfactory nerve; however, to date, there is no characterization of brain regions targeted during HSV-1 primary infection.<\/p>\n<p>Furthermore, the immune response by microglia may also contribute to the heterogeneity between different brain regions. However, the response to HSV-1 by microglia has not been characterized in a region-specific manner.<\/p>\n<p>This study investigated the time course of HSV-1 spread within the olfactory epithelium (OE) and CNS following intranasal inoculation and the corresponding macrophage\/microglial response in a C57BL\/6 mouse model.<\/p>\n<p>We found an apical to basal spread of HSV-1 within the OE and underlying tissue accompanied by an inflammatory response of macrophages. OE infection was followed by infection of a small subset of brain regions targeted by the TG in the brainstem and other cranial nerve nuclei, including the vagus and hypoglossal nerve.<\/p>\n<p>Furthermore, other brain regions were positive for HSV-1 antigens, such as the locus coeruleus (LC), raphe nucleus (RaN), and hypothalamus while sparing the hippocampus and cortex.<\/p>\n<p>Within each brain region, microglia activation also varied widely. These findings provide critical insights into the region-specific dissemination of HSV-1 within the CNS, elucidating potential mechanisms linking viral infection to neurological and neurodegenerative diseases.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/hsv-1-neurology-brain-27962\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Research has shown that HSV-1, the virus responsible for cold sores, can spread into specific areas of the brain and may contribute to neurodegenerative diseases. Mapping HSV-1\u2019s path reveals &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=121159\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-121159","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/121159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=121159"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/121159\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=121159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=121159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=121159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}