{"id":121171,"date":"2024-11-02T10:10:51","date_gmt":"2024-11-02T03:10:51","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=121171"},"modified":"2024-11-02T10:10:51","modified_gmt":"2024-11-02T03:10:51","slug":"chemists-broke-a-100-year-old-rule-to-make-extremely-unstable-molecules","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=121171","title":{"rendered":"Chemists broke a 100-year-old rule to make extremely unstable molecules"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div itemprop=\"articleBody\" id=\"article-body\">\n<p>Scientists have broken a 100-year-old <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/chemistry\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/chemistry\"><u>chemistry<\/u><\/a> rule to synthesize a class of molecules previously thought to be too unstable to form.<\/p>\n<p>The molecules in question violate Bredt&#8217;s rule, which describes where certain types of bonds can occur within a class of 3D chemical compounds. Successfully synthesizing these &#8220;anti-Bredt&#8221; molecules, as described Nov. 1 in the journal<a data-analytics-id=\"inline-link\" href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adq3519\" target=\"_blank\" data-url=\"https:\/\/www.science.org\/doi\/10.1126\/science.adq3519\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"> <u>Science<\/u><\/a>, could help scientists make new kinds of medicine.<\/p>\n<aside class=\"hawk-nest\" data-block-type=\"embed\" data-render-type=\"fte\" data-skip=\"dealsy\" data-widget-type=\"seasonal\"\/>\n<p>&#8220;If there&#8217;s a rule that says something absolutely is impossible, then maybe you just haven&#8217;t thought of the right way of solving it. And if you do it, it actually might not be as difficult as you think,&#8221; study first author <a data-analytics-id=\"inline-link\" href=\"https:\/\/garg.chem.ucla.edu\/group-members\" target=\"_blank\" data-url=\"https:\/\/garg.chem.ucla.edu\/group-members\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Luca McDermott<\/u><\/a>, an organic chemist at UCLA, told Live Science.<\/p>\n<p>The anti-Bredt molecules fall into a class of compounds known as olefins. Olefins have at least one double bond \u2014 a strong chemical bond made from two pairs of electrons \u2014 connecting two <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/28698-facts-about-carbon.html\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/28698-facts-about-carbon.html\"><u>carbon<\/u><\/a> atoms. Each of those carbon atoms usually lies in the same 2D plane as the other atoms to which it&#8217;s bonded.<\/p>\n<p>Early in the 20th century, German chemist Julius Bredt studied double bonds in bicyclic molecules, a group of chemicals that contain two ring-shaped structures stuck together. To get an idea of the shape of these bicyclic molecules, imagine folding two five-sided sticky notes in half and sticking them together back to back. You&#8217;d end up with a roughly Y-shaped 3D structure.<\/p>\n<p><strong>Related: <\/strong><a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/chemistry\/inside-the-20-year-quest-to-unravel-the-bizarre-realm-of-quantum-superchemistry\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/chemistry\/inside-the-20-year-quest-to-unravel-the-bizarre-realm-of-quantum-superchemistry\"><u><strong>Inside the 20-year quest to unravel the bizarre realm of &#8216;quantum superchemistry&#8217;<\/strong><\/u><\/a><\/p>\n<p>Bredt&#8217;s rule, based on his observations in the laboratory, states that the carbon <a data-analytics-id=\"inline-link\" href=\"https:\/\/www.livescience.com\/37206-atom-definition.html\" data-before-rewrite-localise=\"https:\/\/www.livescience.com\/37206-atom-definition.html\"><u>atoms<\/u><\/a> at the junctions of that &#8220;Y&#8221; \u2014 otherwise known as the bridgehead position \u2014 can&#8217;t have a double bond. Since the bridgehead carbon and its surrounding atoms don&#8217;t all lie in the same plane, Bredt predicted that introducing a double bond at the bridgehead position would make the molecule too unstable to exist.<\/p>\n<div id=\"slice-container-newsletterForm-articleInbodyContent-Ehc4KJQgMoSuUdEcaJcuJ4\" class=\"slice-container newsletter-inbodyContent-slice newsletterForm-articleInbodyContent-Ehc4KJQgMoSuUdEcaJcuJ4 slice-container-newsletterForm\">\n<div data-hydrate=\"true\" class=\"newsletter-form__wrapper newsletter-form__wrapper--inbodyContent\">\n<div class=\"newsletter-form__container\">\n<section class=\"newsletter-form__top-bar\"\/>\n<section class=\"newsletter-form__main-section\">\n<p class=\"newsletter-form__strapline\">Get the world\u2019s most fascinating discoveries delivered straight to your inbox.<\/p>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<p>Now, McDermott and his colleagues have come up with a way to make anti-Bredt olefins and used the method to synthesize complex 3D molecules. Because the anti-Bredt olefins are unstable and highly reactive, the team wasn&#8217;t able to isolate them directly in the new study. Instead, they added other molecules that could immediately react with the anti-Bredt olefins and form more stable products. That allowed them to experiment with several different variations on anti-Bredt olefins and their more stable products.<\/p>\n<p>Reactions using anti-Bredt olefins could open doors to new types of medicines, study co-author <a data-analytics-id=\"inline-link\" href=\"https:\/\/garg.chem.ucla.edu\/about-neil\" target=\"_blank\" data-url=\"https:\/\/garg.chem.ucla.edu\/about-neil\" referrerpolicy=\"no-referrer-when-downgrade\" data-hl-processed=\"none\" rel=\"noopener\"><u>Neil Garg<\/u><\/a>, a professor and chemist at UCLA, told Live Science. The rigid, 3D structures could interact better with proteins in the body than existing flat medicinal compounds, he suggested.<\/p>\n<p>The researchers said they plan to synthesize more compounds with unusual structures and explore new types of reactivity in the future.<\/p>\n<p>&#8220;If we can question [Bredt&#8217;s rule] after 100 years and push the limits of it, there&#8217;s probably all sorts of other rules that are waiting to be reexamined,&#8221; Garg said.<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.livescience.com\/chemistry\/chemists-broke-a-100-year-old-rule-to-make-extremely-unstable-molecules\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have broken a 100-year-old chemistry rule to synthesize a class of molecules previously thought to be too unstable to form. The molecules in question violate Bredt&#8217;s rule, which describes &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=121171\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8628],"tags":[],"class_list":["post-121171","post","type-post","status-publish","format-standard","hentry","category-science","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/121171","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=121171"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/121171\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=121171"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=121171"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=121171"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}