{"id":122222,"date":"2024-11-05T05:40:44","date_gmt":"2024-11-04T22:40:44","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=122222"},"modified":"2024-11-05T05:40:44","modified_gmt":"2024-11-04T22:40:44","slug":"keto-diet-may-ease-multiple-sclerosis-symptoms","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=122222","title":{"rendered":"Keto Diet May Ease Multiple Sclerosis Symptoms"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>New research suggests the ketogenic diet could help manage multiple sclerosis (MS) by promoting the production of beneficial compounds in the gut. In a study, mice on a keto diet produced the ketone body \u03b2-hydroxybutyrate (\u03b2HB), which worked with gut bacteria to create immune-modulating metabolites. This interaction reduced inflammation and improved MS symptoms in mice.<\/p>\n<p>If these findings translate to humans, the approach could lead to supplement-based treatments for autoimmune diseases, offering a less restrictive option than the keto diet. Future studies are needed to confirm the therapeutic potential in people with autoimmune conditions.<\/p>\n<p><strong>Key Facts<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Keto diet-derived \u03b2HB in mice triggered beneficial gut microbes to produce anti-inflammatory compounds.<\/li>\n<li>Gut bacteria <em>Lactobacillus murinus<\/em> created indole lactic acid (ILA), which reduced harmful immune activity linked to MS.<\/li>\n<li>Findings suggest supplements might offer a more accessible alternative for managing MS symptoms.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>UCSF<\/p>\n<p><strong>Scientists have long suspected the keto diet might be able to calm an overactive immune system and help some people with diseases like multiple sclerosis.<\/strong><\/p>\n<p>Now, they have reason to believe it could be true.<\/p>\n<p>Scientists at UC San Francisco have discovered that the diet makes the gut and its microbes produce two factors that attenuated symptoms of MS in mice.<\/p>\n<p>If the study translates to humans, it points toward a new way of treating MS and other autoimmune disorders with supplements.<\/p>\n<p>The keto diet severely restricts carbohydrate-rich foods like bread, pasta, fruit and sugar, but allows unlimited fat consumption.<\/p>\n<p>Without carbohydrates to use as fuel, the body breaks down fat instead, producing compounds called ketone bodies. Ketone bodies provide energy for cells to burn and can also change the immune system.<\/p>\n<p>Working with a mouse model of MS, the researchers found that mice who produced more of a particular ketone body, called \u03b2-hydroxybutyrate (\u03b2HB), had less severe disease.<\/p>\n<p>The additional \u03b2HB also prompted the gut bacterium\u00a0<em>Lactobacillus murinus<\/em>\u00a0to produce a metabolite called indole lactic acid (ILA). This blocked the activation of T helper 17 immune cells, which are involved in MS and other autoimmune disorders.<\/p>\n<p>\u201cWhat was really exciting was finding that we could protect these mice from inflammatory disease just by putting them on a diet that we supplemented with these compounds,\u201d said\u00a0Peter Turnbaugh, PhD, of the\u00a0Benioff Center for Microbiome Medicine.<\/p>\n<p>Earlier, Turnbaugh had shown that when secreted by the gut, \u03b2HB counteracts immune activation. This prompted a postdoctoral scholar who was then working in his lab, Margaret Alexander, PhD, to see if the compound could ease the symptoms of MS in mice.<\/p>\n<p>In the new study, which appears Nov. 4 in\u00a0<em>Cell Reports<\/em>, the team looked at how the ketone body-rich diet affected mice that were unable to produce \u03b2HB in their intestines, and found that their inflammation was more severe.<\/p>\n<p>But when the researchers supplemented their diets with \u03b2HB, the mice got better.<\/p>\n<p>To find out how \u03b2HB affects the gut microbiome, the team isolated bacteria from the guts of three groups of mice that were fed either the keto diet, a high-fat diet, or the \u03b2HB supplemented high-fat diet.<\/p>\n<p>Then, they screened the metabolic products of each group\u2019s distinct microbes in an immune assay and determined that the positive effects of the diet were coming from a member of the\u00a0<em>Lactobacillus<\/em>\u00a0genus:\u00a0<em>L. murinus<\/em>.<\/p>\n<p>Two other techniques, genome sequencing and mass spectrometry, confirmed that the L. murinus they found produced indole lactic acid, which is known to affect the immune system.<\/p>\n<p>Finally, the researchers treated the MS mice with either ILA or L. murinus, and their symptoms improved.<\/p>\n<p>Turnbaugh cautioned that the supplement approach still needs to be tested in people with autoimmune disorders.<\/p>\n<p>\u201cThe big question now is how much of this will translate into actual patients,\u201d he said. \u201cBut I think these results provide hope for the development of a more tolerable alternative to helping those people than asking them stick to a challenging restrictive diet.\u201d<\/p>\n<p><strong>Authors:<\/strong>\u00a0Additional authors of the study include Margaret Alexander, Vaibhav Upadhyay, Rachel Rock, Lorenzo Ramirez, Kai Trepka, Diego Oreilana, Qi Yan Ang, Caroline Whitty, Jessie Turnbaugh, Darren Dumlao, Renuka Nayak, and John C. Newman of UCSF, Patrycja Puchalska and Peter Crawford of the University of Minnesota, and Yuan Tian and Andrew Patterson Pennsylvania State University.<\/p>\n<p><strong>Funding:<\/strong>\u00a0This work was funded by the NIH (grants P30 DK063720, R01DK114034, R01HL122593, R01AR074500, R01AT011117, F32AI14745601, K99AI159227, R00AI159227-03, K08HL165106, K08AR073930, R01AG067333, R01DK091538, R01AG069781) and the Damon Runyon Cancer Research Foundation (DRR4216). Turnbaugh is a Chan Zuckerberg Biohub-San Francisco Investigator.<\/p>\n<h2 class=\"wp-block-heading\">About this multiple sclerosis research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#ddafb2bfb4b3f3b0bcafb6ae9da8beaebbf3b8b9a8\" target=\"_blank\" rel=\"noreferrer noopener\">Robin Marks<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/ucsf.edu\" target=\"_blank\" rel=\"noreferrer noopener\">UCSF<\/a><br \/><strong>Contact: <\/strong>Robin Marks \u2013 UCSF<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)01242-7\" target=\"_blank\" rel=\"noreferrer noopener\">A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity<\/a>\u201d by Peter Turnbaugh et al. <em>Cell Reports<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity<\/strong><\/p>\n<p>Diet can protect from autoimmune disease; however, whether diet acts via the host and\/or microbiome remains unclear. Here, we use a ketogenic diet (KD) as a model to dissect these complex interactions.<\/p>\n<p>A KD rescued the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis in a microbiota-dependent fashion. Dietary supplementation with a single KD-dependent host metabolite (\u03b2-hydroxybutyrate [\u03b2HB]) rescued EAE, whereas transgenic mice unable to produce \u03b2HB in the intestine developed more severe disease.<\/p>\n<p>Transplantation of the \u03b2HB-shaped gut microbiota was protective.\u00a0<em>Lactobacillus<\/em>\u00a0sequence variants were associated with decreased T helper 17 cell activation\u00a0<em>in\u00a0vitro<\/em>.<\/p>\n<p>Finally, we isolated an\u00a0<em>L<\/em>.\u00a0<em>murinus<\/em>\u00a0strain that protected from EAE, which was phenocopied by a\u00a0<em>Lactobacillus<\/em>\u00a0metabolite enriched by \u03b2HB supplementation, indole lactate.<\/p>\n<p>Thus, diet\u00a0alters the immunomodulatory potential of the gut microbiota by shifting host metabolism, emphasizing the utility of taking a more integrative approach to study diet-host-microbiome interactions.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/keto-diet-ms-microbiome-27978\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: New research suggests the ketogenic diet could help manage multiple sclerosis (MS) by promoting the production of beneficial compounds in the gut. 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