{"id":122414,"date":"2024-11-05T17:54:53","date_gmt":"2024-11-05T10:54:53","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=122414"},"modified":"2024-11-05T17:54:53","modified_gmt":"2024-11-05T10:54:53","slug":"the-cold-sore-virus-can-infect-your-brain-but-how-does-it-get-inside-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=122414","title":{"rendered":"The Cold Sore Virus Can Infect Your Brain. But How Does It Get Inside? : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>We already know that the  <a href=\"https:\/\/www.sciencealert.com\/virus\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73053\" data-postid=\"142284\" rel=\"nofollow noopener\" target=\"_self\">virus<\/a> behind <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cold_sore\">cold sores<\/a>, herpes simplex virus type 1 (HSV-1), can also infect the brain and the central nervous system, and now a new study sheds more light on how the viral attack spreads out.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Led by researchers from the University of Colorado and the University of Bourgogne in France, the study took a close look at the effects of the HSV-1 virus on the brains of mice, mapping out the different regions affected and assessing what the consequences might be.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>HSV-1 can be introduced to the central nervous system through two routes \u2013 the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Trigeminal_nerve\">trigeminal nerve<\/a> or the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Olfactory_system\">olfactory nerve<\/a> \u2013 although it remains unclear how the infection then spreads within the brain.<\/p>\n<figure id=\"attachment_142288\" aria-describedby=\"caption-attachment-142288\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/ColdSore.jpg\" alt=\"Cold sore\" width=\"642\" height=\"446\" class=\"wp-image-142288 size-full\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/ColdSore.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/ColdSore-597x415.jpg 597w, https:\/\/www.sciencealert.com\/images\/2024\/11\/ColdSore-600x417.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-142288\" class=\"wp-caption-text\">Cold sores are signs of HSV-1. (<a href=\"https:\/\/en.wikipedia.org\/wiki\/Cold_sore#\/media\/File:Herpes(PHIL_1573_lores).jpg\">Wikimedia Commons\/Public Domain<\/a>)<\/figcaption><\/figure>\n<p>&#8220;Recently, this common virus has been implicated in neurodegenerative diseases, such as  <a href=\"https:\/\/www.sciencealert.com\/go\/IaO\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73015\" data-postid=\"142284\" rel=\"nofollow noopener\" target=\"_self\">Alzheimer&#8217;s<\/a> disease, but no clear route of central nervous system invasion has been established,&#8221; <a href=\"https:\/\/news.cuanschutz.edu\/news-stories\/silent-intruder-how-the-cold-sore-virus-maps-its-way-through-the-brain\">says<\/a> neurologist Christy Niemeyer from the University of Colorado.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Identifying how HSV-1 can get into the brain and what brain regions are vulnerable is key in understanding how it initiates disease.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The team found that HSV-1 took hold in several of the brain&#8217;s most important regions, including the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Brainstem\">brain stem<\/a> (responsible for co-ordinating heart and breath rate, along with sleep and movement), and the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Hypothalamus\">hypothalamus<\/a> (which handles everything from sleep and moods to appetite and hormone levels).<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>However, other areas of the brain remained untouched by HSV-1 antigens, including the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Hippocampus\">hippocampus<\/a> (the region that looks after memory and special navigation, often connected to diseases like Alzheimer&#8217;s) and the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cerebral_cortex\">cortex<\/a> (linked to memory and attention).<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The researchers also looked at the activity of <a href=\"https:\/\/en.wikipedia.org\/wiki\/Microglia\">microglia <\/a>(in-house immune cells of the central nervous system) in the mouse brains, which became inflamed when interacting with HSV-1. In certain regions, these immune cells stayed busy even after the virus had gone, suggesting ongoing inflammation.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>In the most serious cases, HSV-1 can cause <a href=\"https:\/\/en.wikipedia.org\/wiki\/Encephalitis\">encephalitis<\/a>, a life-threatening condition where inflammation affects the whole brain. While this didn&#8217;t happen here, the research shows there might still be damage being done.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Even though the presence of HSV-1 is not causing full-blown encephalitis in the brain, it can still affect how these regions function,&#8221; <a href=\"https:\/\/news.cuanschutz.edu\/news-stories\/silent-intruder-how-the-cold-sore-virus-maps-its-way-through-the-brain\">says<\/a> Niemeyer.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>All of this additional knowledge gives scientists a better idea of how HSV-1 infections might be related to neurodegenerative diseases \u2013 something which has been the subject of <a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.12008\">several recent studies<\/a>. The new study is another useful step forward that further research can now build on.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>It&#8217;s been suggested that HSV-1 and microglia-related inflammation could be part of the reason why Alzheimer&#8217;s takes hold in some brains, or they may have some effect on its rate of progress. With that in mind, it&#8217;s interesting to see where there&#8217;s overlap in the brain regions affected by both HSV-1 and Alzheimer&#8217;s.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Persistently inflamed cells can lead to chronic inflammation, a known trigger for a number of neurological and neurodegenerative diseases,&#8221; <a href=\"https:\/\/news.cuanschutz.edu\/news-stories\/silent-intruder-how-the-cold-sore-virus-maps-its-way-through-the-brain\">says<\/a> Niemeyer.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;This research offers important takeaways in better understanding how  <a href=\"https:\/\/www.sciencealert.com\/virus\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73053\" data-postid=\"142284\" rel=\"nofollow noopener\" target=\"_self\">viruses<\/a> interact with overall brain health as well as the onset of pervasive neurological diseases.&#8221;<\/p>\n<p>The research has been published in the <a href=\"https:\/\/journals.asm.org\/doi\/10.1128\/jvi.00968-24\"><em>Journal of Virology<\/em><\/a>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/the-cold-sore-virus-can-infect-your-brain-but-how-does-it-get-inside\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We already know that the virus behind cold sores, herpes simplex virus type 1 (HSV-1), can also infect the brain and the central nervous system, and now a new study &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=122414\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-122414","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/122414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=122414"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/122414\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=122414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=122414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=122414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}