{"id":122588,"date":"2024-11-06T05:06:00","date_gmt":"2024-11-05T22:06:00","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=122588"},"modified":"2024-11-06T05:06:00","modified_gmt":"2024-11-05T22:06:00","slug":"gene-study-links-alcohol-addiction-to-accelerated-alzheimers-progression","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=122588","title":{"rendered":"Gene Study Links Alcohol Addiction to Accelerated Alzheimer\u2019s Progression"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers discovered alcohol use disorder (AUD) and Alzheimer\u2019s disease (AD) exhibit similar patterns of gene dysregulation, hinting that alcohol consumption may hasten Alzheimer\u2019s progression. By analyzing gene expression across individual brain cells, the team found shared disruptions in inflammation, cell signaling, and blood vessel functions in both disorders.<\/p>\n<p>These findings highlight AUD as a potential risk factor for AD and could lead to new therapeutic targets. The research underscores the need to consider alcohol\u2019s impact in Alzheimer\u2019s prevention and treatment strategies. Future studies aim to validate findings with larger AUD datasets.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Both AUD and AD show similar gene dysregulation in inflammation and cell signaling.<\/li>\n<li>AUD may increase Alzheimer\u2019s progression by targeting overlapping molecular pathways.<\/li>\n<li>Single-cell RNA sequencing reveals shared cellular vulnerabilities between AUD and AD.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Scripps Research Institute<\/p>\n<p><strong>Nearly 7 million Americans have Alzheimer\u2019s disease, and this number is predicted to double by 2060. While aging and genetic predisposition are the most important risk factors for Alzheimer\u2019s, epidemiological studies suggest that lifestyle factors including alcohol use could also impact disease onset and progression.<\/strong><\/p>\n<p>Now, Scripps Research scientists have shown that Alzheimer\u2019s and\u00a0alcohol use disorder\u00a0(AUD) are associated with similarly altered\u00a0gene expression patterns\u00a0in the brain, supporting the idea that alcohol use may promote Alzheimer\u2019s disease progression.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105915\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"799\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence.jpg\" alt=\"This shows a man's face and broken bottles.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/aud-alzheimers-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">They showed that both AUD and Alzheimer\u2019s are associated with similar gene expression changes in the brain, including upregulation of inflammatory genes and pathways, disruption to cell signaling and cell-death-related pathways, and changes to blood vessel cells. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The study, published in\u00a0<em>eNeuro<\/em>\u00a0on September 19, 2024, could inform future preventative and treatment strategies.<\/p>\n<p>\u201cWe found several cell-type-specific genes and pathways that are dysregulated in both Alzheimer\u2019s disease and alcohol, which supports the hypothesis that alcohol use disorder can accelerate Alzheimer\u2019s disease progression by impinging on some of the same\u00a0molecular mechanisms\u00a0that are affected by Alzheimer\u2019s,\u201d says senior author Pietro Paolo Sanna, MD, a professor in the Immunology and Microbiology Department at Scripps Research.<\/p>\n<p>\u201cBy understanding these dysregulations with this level of molecular detail, we can understand what\u2019s causing these diseases, and we can also identify targets that could be used therapeutically.\u201d<\/p>\n<p>This is the first time researchers have used single cell transcriptomics\u2014a method that analyzes gene expression within\u00a0individual cells\u00a0by sequencing their RNA\u2014to compare changes associated with Alzheimer\u2019s disease and AUD in different populations of human brain cells.<\/p>\n<p>The study builds upon previously published research in the Sanna lab that showed that\u00a0excessive alcohol consumption accelerates Alzheimer\u2019s progression\u00a0in mice that are genetically predisposed to the disease.<\/p>\n<p>To examine cell-specific gene expression changes, the team analyzed RNA sequencing data from hundreds of thousands of individual brain cells from 75 patients with varying stages of Alzheimer\u2019s disease (early, intermediate or advanced), and 10 patients without Alzheimer\u2019s.<\/p>\n<p>Then, they compared this Alzheimer\u2019s gene expression data with previously published RNA sequencing data from individuals with AUD.<\/p>\n<p>They showed that both AUD and Alzheimer\u2019s are associated with similar gene expression changes in the brain, including upregulation of inflammatory genes and pathways, disruption to\u00a0cell signaling\u00a0and cell-death-related pathways, and changes to blood vessel cells.<\/p>\n<p>\u201cWhat we\u2019ve presented here is a differential analysis of two disorders that cause\u00a0cognitive decline,\u201d says first author Arpita Joshi, Ph.D., a staff scientist in Sanna\u2019s lab at Scripps Research.<\/p>\n<p>\u201cIt deepens our understanding of Alzheimer\u2019s disease and what the three clinically defined stages of Alzheimer\u2019s entail, and it underscores the importance of considering alcohol use disorder as a risk factor for Alzheimer\u2019s.\u201d<\/p>\n<p>Because the study was based on a small sample size for AUD, in the future, researchers plan to repeat their analysis using larger gene expression databases from individuals with AUD, which they expect to become available in the next year.<\/p>\n<p>\u201cWe are eagerly awaiting the release of larger alcohol use datasets so that we can test the robustness of these findings and examine the commonalities between the two disorders with finer cell-type granularity,\u201d says Joshi.<\/p>\n<p>\u201cThis is a global effort to unravel complex diseases at the single-cell level, which will lead to a better understanding of the molecular and cellular perturbations in individuals with Alzheimer\u2019s disease, alcohol use disorder, and their interactions.\u201d<\/p>\n<p>In addition to Sanna and Joshi, the study, \u201cTranscriptional Patterns in Stages of Alzheimer\u2019s Disease Are Cell-Type\u2013Specific and Partially Converge with the Effects of Alcohol Use Disorder in Humans,\u201d was co-authored by Federico Manuel Giorgi of Scripps Research and the University of Bologna.<\/p>\n<h2 class=\"wp-block-heading\">About this AUD and Alzheimer\u2019s disease research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/www.scripps.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Pietro Paolo Sanna<\/a><br \/><strong>Source: <\/strong><a href=\"http:\/\/www.scripps.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">Scripps Research Institute<\/a><br \/><strong>Contact: <\/strong>Pietro Paolo Sanna \u2013 Scripps Research Institute<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/www.eneuro.org\/content\/11\/10\/ENEURO.0118-24.2024\" target=\"_blank\" rel=\"noreferrer noopener\">Transcriptional Patterns in Stages of Alzheimer\u2019s Disease Are Cell-Type\u2013Specific and Partially Converge with the Effects of Alcohol Use Disorder in Humans<\/a>\u201d by Pietro Paolo Sanna et al. <em>eNeuro<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Transcriptional Patterns in Stages of Alzheimer\u2019s Disease Are Cell-Type\u2013Specific and Partially Converge with the Effects of Alcohol Use Disorder in Humans<\/strong><\/p>\n<p>Advances in single-cell technologies have led to the discovery and characterization of new brain cell types, which in turn lead to a better understanding of the pathogenesis of Alzheimer\u2019s disease (AD).<\/p>\n<p>Here, we present a detailed analysis of single-nucleus (sn)RNA-seq data for three stages of AD from middle temporal gyrus and compare it with snRNA-seq data from the prefrontal cortices from individuals with alcohol use disorder (AUD).<\/p>\n<p>We observed a significant decrease in both inhibitory and excitatory neurons, in general agreement with previous reports. We observed several cell-type\u2013specific gene expressions and pathway dysregulations that delineate AD stages.<\/p>\n<p>Endothelial and vascular leptomeningeal cells showed the greatest degree of gene expression changes. Cell-type\u2013specific evidence of neurodegeneration was seen in multiple neuronal cell types particularly in somatostatin and Layer 5 extratelencephalic neurons, among others.<\/p>\n<p>Evidence of inflammatory responses was seen in non-neuronal cells, particularly in intermediate and advanced AD.<\/p>\n<p>We observed common perturbations in AD and AUD, particularly in pathways, like transcription, translation, apoptosis, autophagy, calcium signaling, neuroinflammation, and phosphorylation, that imply shared transcriptional pathogenic mechanisms and support the role of excessive alcohol intake in AD progression.<\/p>\n<p>Major AUD gene markers form and perturb a network of genes significantly associated with intermediate and advanced AD.<\/p>\n<p>Master regulator analysis from AUD gene markers revealed significant correlation with advanced AD of transcription factors that have implications in intellectual disability, neuroinflammation, and other neurodegenerative conditions, further suggesting a shared nexus of transcriptional changes between AD and AUD.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/genetics-aud-alzheimers-27981\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers discovered alcohol use disorder (AUD) and Alzheimer\u2019s disease (AD) exhibit similar patterns of gene dysregulation, hinting that alcohol consumption may hasten Alzheimer\u2019s progression. By analyzing gene expression across &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=122588\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-122588","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/122588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=122588"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/122588\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=122588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=122588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=122588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}