{"id":123459,"date":"2024-11-08T12:05:52","date_gmt":"2024-11-08T05:05:52","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=123459"},"modified":"2024-11-08T12:05:52","modified_gmt":"2024-11-08T05:05:52","slug":"researchers-might-have-found-working-cancer-treatment","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=123459","title":{"rendered":"Researchers might have found working cancer treatment"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div id=\"startBannerSticky\">&#13;<\/p>\n<p>Researchers at <a href=\"https:\/\/www.jpost.com\/tags\/habima\">Tel Aviv University<\/a> have uncovered a cancer mechanism that prevents the immune system from attacking tumors, a breakthrough that could pave the way for more effective immunotherapies, according to a paper published late September.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<p>The discovery, led by Prof. Carmit Levy, Prof. Yaron Carmi, and PhD student Avishai Maliah, was published in the peer-reviewed academic journal <em>Nature Communications<\/em> and discussed that reversing the newly discovered mechanism stimulates the immune system to target cancer cells, even in types of <a href=\"https:\/\/www.jpost.com\/tags\/cancer\">cancer<\/a> that tend to be more resistant to existing therapies.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<p>According to the researchers, the breakthrough emerged by chance while studying both cancer and the effects of ultraviolet (UV) radiation on the immune system. &#8220;We proposed a different approach: investigating how UV exposure suppresses the <a href=\"https:\/\/www.jpost.com\/tags\/immune-system\">immune system<\/a> and applying our findings to cancer,&#8221; Prof. Levy explained.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<section class=\"fake-br-for-article-body\"\/>\n<section class=\"hide-for-premium\">  <\/section>\n<section class=\"fake-br-for-article-body\"\/>\n<p>The researchers discovered that UV exposure caused a significant increase in the expression of a protein associated with immune response, which was initially identified in the skin after UV exposure. This led them to investigate its role in cancer.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<figure class=\"article-image-in-body\"><figcaption class=\"article-image-caption article-image-credit\" style=\"max-width:100%;height:auto;\"> Prof. Carmit Levy (LEFT) &amp; Prof. Yaron Carmi (RIGHT). (credit: TEL AVIV UNIVERSITY)<\/figcaption><\/figure>\n<\/p>\n<p>Avishai Maliah, who led the project, found that the protein was overexpressed in cancerous tumors, including melanoma and colon cancer, and likely served as a &#8220;brake&#8221; to inhibit T cells\u2014immune cells that play a critical role in fighting cancer. &#8220;We suspected that [the protein] serves as a brake through which UV inhibits the immune system, and that by releasing this brake, optimal activation of the immune system might be resumed,&#8221; Maliah said.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<h3><strong>Protein to enhance immunotherapy<\/strong><\/h3>\n<p>Prof. Levy and the team\u2019s hypothesis was seemingly confirmed, according to them, when treatment with antibodies relating to the protein led to substantial tumor shrinkage in animal models, even in cases where the cancers had been resistant to other forms of immunotherapy.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<p>Prof. Levy remarked, &#8220;We were surprised to discover that this protein, Ly6a, is also overexpressed in cancer tumors\u2014apparently inhibiting T cells.&#8221; Their findings suggest that the protein could be a key player in how tumors affect the immune system.<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<section class=\"hide-for-premium\"> <\/section>\n<\/p>\n<p>The breakthrough has significant implications for immunotherapy, &#8220;Immunotherapy has revolutionized the treatment of cancer. However, about 50% of patients do not respond to the currently prevailing treatment,&#8221; Prof. Carmi explained. &#8220;We discovered a new protein, and found that its antibody eradicated tumors in our model animals.&#8221;<\/p>\n<section class=\"fake-br-for-article-body\"\/>\n<p>The team is working to translate their findings into a potential treatment for human cancer patients, with hopes of offering an innovative treatment option for those who currently have limited responses to existing therapies.<\/p>\n<p>&#13;<\/p>\n<section>&#13;<br \/>\n\t\t\t\t\t&#13;<br \/>\n\t\t\t\t<\/section>\n<p>&#13;\n\t\t\t<\/p><\/div>\n<p><script>\n  !function(f,b,e,v,n,t,s)\n  {if(f.fbq)return;n=f.fbq=function(){n.callMethod?\n  n.callMethod.apply(n,arguments):n.queue.push(arguments)};\n  if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';\n  n.queue=[];t=b.createElement(e);t.async=!0;\n  t.src=v;s=b.getElementsByTagName(e)[0];\n  s.parentNode.insertBefore(t,s)}(window, document,'script',\n  'https:\/\/connect.facebook.net\/en_US\/fbevents.js');\n  fbq('init', '1730128020581377');\n  fbq('track', 'PageView');\n<\/script><br \/>\n<br \/><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.jpost.com\/health-and-wellness\/article-828086\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#13; Researchers at Tel Aviv University have uncovered a cancer mechanism that prevents the immune system from attacking tumors, a breakthrough that could pave the way for more effective immunotherapies, &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=123459\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-123459","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/123459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=123459"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/123459\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=123459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=123459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=123459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}