{"id":123747,"date":"2024-11-09T06:24:29","date_gmt":"2024-11-08T23:24:29","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=123747"},"modified":"2024-11-09T06:24:29","modified_gmt":"2024-11-08T23:24:29","slug":"keto-diet-protects-against-ms-in-mice-by-modifying-gut-bacteria","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=123747","title":{"rendered":"Keto diet protects against MS in mice by modifying gut bacteria"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>A <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499830\/\">ketogenic diet<\/a> \u2014 a very low-carbohydrate, high-fat eating plan called a keto diet for short \u2014 was able to lessen the severity of <a href=\"https:\/\/multiplesclerosisnewstoday.com\/multiple-sclerosis-overview\/\">multiple sclerosis<\/a> (MS) in mouse models by modulating the activity of gut bacteria and their metabolites, a new study shows.<\/p>\n<p>The findings suggest that molecules made by gut bacteria are key for the beneficial effects of this type of diet in MS models, implying that supplements of these bacterial-made molecules might be a useful strategy for treating MS in people.<\/p>\n<p>\u201cWhat was really exciting was finding that we could protect these mice from inflammatory disease just by putting them on a diet that we supplemented with these compounds,\u201d Peter Turnbaugh, PhD, co-author of the study at the University of California, San Francisco, said in a <a href=\"https:\/\/www.ucsf.edu\/news\/2024\/11\/428771\/how-keto-diet-could-one-day-treat-autoimmune-disorders\">university news story<\/a>.<\/p>\n<p>The study noted that \u201cif this finding holds in humans, [such] supplementation alone could offer a viable therapeutic alternative.\u201d<\/p>\n<p>Titled \u201c<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)01242-7\"><span style=\"text-decoration: underline;\">A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity<\/span><\/a>,\u201d the study was published in the journal <em>Cell Reports<\/em>.<\/p>\n<div class=\"bio-post-preview-inline\">\n  <span class=\"bio-post-preview--eyebrow bio-type-body--xsmall\">Recommended Reading<\/span><\/p>\n<div class=\"bio-post-preview-inline--card bio-card--shadow \">\n<div class=\"bio-post-preview--image\">\n      <img decoding=\"async\" src=\"https:\/\/multiplesclerosisnewstoday.com\/wp-content\/uploads\/2021\/09\/Bionews_Expertvoices_v1-150x0-c-default.png\" alt=\"Doctors, scientists and other medical professionals going about their daily routine with \" expert=\"\" voices=\"\" logo=\"\" in=\"\" front.=\"\"\/>\n    <\/div>\n<\/p><\/div>\n<\/div>\n<h3>Molecules made by gut bacteria key to beneficial effects of keto diet<\/h3>\n<p><a href=\"https:\/\/multiplesclerosisnewstoday.com\/living-with-ms\/ms-diet-nutrition\/healthy-eating-ms\/\">Diet<\/a> can have profound effects on health for all people, but especially those with autoimmune diseases like MS and other conditions. A ketogenic, or keto, diet involves minimizing the intake of carbohydrates, which forces the body to burn fat for energy. The diet gets its name because, when the body is using fats as its main source of energy, it makes molecules called ketone bodies.<\/p>\n<p>There isn\u2019t any one diet recommended for people with MS, although the keto diet is one dietary strategy that is sometimes explored by people with the disease. Some small studies have indicated that this eating plan may <a href=\"https:\/\/multiplesclerosisnewstoday.com\/news-posts\/2022\/05\/06\/ketogenic-diet-clinical-trial-quality-of-life-rrms\/\">help to ease fatigue and depression<\/a>, and experimental evidence also suggests that a keto diet can lessen disease severity in animal models of MS.<\/p>\n<p>However, it hasn\u2019t been clear why exactly this type of diet shows benefits in MS models.<\/p>\n<p>In this study, the researchers wanted to determine whether the impact of a keto diet in MS models is dependent on the gut microbiome \u2014 the billions of bacteria and other microorganisms that live in the intestinal tract.<\/p>\n<p>In their initial experiments, the researchers induced experimental autoimmune encephalomyelitis, or EAE, an MS-like disease, in mice, then fed the animals either a high-fat diet or a ketogenic one. In line with prior research, mice given the ketogenic diet had much less severe disease.<\/p>\n<p>The researchers then repeated the experiment using germ-free mice that were engineered to completely lack a gut microbiome. Contrasting with the original findings, disease severity was comparable in germ-free mice fed a ketogenic or high-fat diet, illustrating that the impact of the ketogenic diet in this model is dependent on gut bacteria.<\/p>\n<p>When mice are fed a ketogenic diet, a ketone body called beta-hydroxybutyrate, or BHB, is significantly increased in circulation relative to the high-fat diet. This molecule is known to modulate the activity of inflammatory immune cells, so the researchers speculated that reduced production of BHB in germ-free mice might explain why these mice didn\u2019t benefit from the keto diet.<\/p>\n<p>Supporting this idea, the researchers found that supplementing the mice\u2019s high-fat diet with BHB led to less severe disease \u2014 similar to that seen with the keto diet.<\/p>\n<p>\u201cWe discovered that oral delivery of a [BHB] can mimic the protective effects of a [ketogenic diet],\u201d the researchers wrote. \u201cThe translational implications [from animals to humans] are profound, as [ketogenic diets] are difficult to maintain and can have negative side effects.\u201d<\/p>\n<div class=\"bio-post-preview-inline\">\n  <span class=\"bio-post-preview--eyebrow bio-type-body--xsmall\">Recommended Reading<\/span><\/p>\n<div class=\"bio-post-preview-inline--card bio-card--shadow \">\n<div class=\"bio-post-preview--image\">\n      <img decoding=\"async\" src=\"https:\/\/multiplesclerosisnewstoday.com\/wp-content\/uploads\/2023\/03\/VariedDiet-1-150x0-c-default.png\" alt=\"An illustration of various healthy foods, including fruits, vegetables, and fish.\"\/>\n    <\/div>\n<\/p><\/div>\n<\/div>\n<h3>Researchers say \u2018big question now\u2019 is translating findings to humans<\/h3>\n<p>In further experiments, the researchers found that BHB leads to an increased abundance of gut bacteria, which can produce an anti-inflammatory compound called indole-3-lactate (ILA).<\/p>\n<p>When EAE mice fed a high-fat diet were treated with either those bacteria or ILA, disease severity was also much lower \u2014 and the mice had a higher likelihood of surviving through day 18 compared with untreated controls.<\/p>\n<p>Studies in humans have shown that people with MS tend to have abnormally low levels of ILA, suggesting a potential mechanism for how these diet-mediated changes in gut bacteria impact disease.<\/p>\n<blockquote class=\"bio-blockquote bio-blockquote--align-left\">\n<p class=\"bio-blockquote-text\">I think these results provide hope for the development of a more tolerable alternative to helping [MS patients] than asking them [to] stick to a challenging and restrictive diet.<\/p>\n<\/blockquote>\n<p>\u201cThe pathway we have identified herein provides a common mechanism through which these diverse dietary interventions may impact MS,\u201d the researchers wrote, noting that these findings set the stage for further experiments to examine the potential of BHB and\/or ILA supplements as a strategy for MS treatment.<\/p>\n<p>According to Turnbaugh, \u201cthe big question now is how much of this will translate into actual patients. \u2026\u00a0I think these results provide hope for the development of a more tolerable alternative to helping [patients] than asking them [to] stick to a challenging and restrictive diet.\u201d<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/multiplesclerosisnewstoday.com\/news-posts\/2024\/11\/08\/keto-diet-modifies-gut-bacteria-protecting-mice-ms\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A ketogenic diet \u2014 a very low-carbohydrate, high-fat eating plan called a keto diet for short \u2014 was able to lessen the severity of multiple sclerosis (MS) in mouse models &hellip; 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