{"id":124100,"date":"2024-11-10T04:47:49","date_gmt":"2024-11-09T21:47:49","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=124100"},"modified":"2024-11-10T04:47:49","modified_gmt":"2024-11-09T21:47:49","slug":"disrupted-eating-cycles-liver-brain-signals-hold-key-to-balance","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=124100","title":{"rendered":"Disrupted Eating Cycles? Liver-Brain Signals Hold Key to Balance"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>A new study highlights how signals from the liver to the brain influence eating patterns tied to our circadian rhythms. This liver-brain communication can become disrupted in people working night shifts or irregular hours, leading to weight gain and metabolic issues.<\/p>\n<p>The research focused on a protein called REV-ERB in the liver that plays a role in regulating this internal clock. When disrupted, mice ate more during inactive hours, but restoring nerve connections improved eating patterns. This study suggests future therapies targeting liver-brain signals could help manage metabolic disorders in those with irregular schedules.<\/p>\n<p><strong>Key Facts<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Circadian Sync<\/strong>: Liver signals to the brain help align eating patterns with circadian rhythms.<\/li>\n<li><strong>REV-ERB\u2019s Role<\/strong>: This protein in liver cells aids in the body\u2019s internal clock, crucial for healthy eating schedules.<\/li>\n<li><strong>Potential Therapy<\/strong>: Targeting liver-brain signals may aid those with disrupted eating patterns due to night shifts or jet lag.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Pennsylvania<\/p>\n<p><strong>People who work the nightshift or odd hours and eat at irregular times are more prone to weight gain and diabetes, likely due to eating patterns not timed with natural daylight and when people typically eat. But is it possible to stave off the ill effects of eating at these \u201cunusual\u201d times despite it not being biologically preferable? <\/strong><\/p>\n<p>A new study from the Perelman School of Medicine at the University of Pennsylvania says \u2018yes\u2019, and sheds light on how the body knows when to eat.<\/p>\n<p>The study, published today in\u00a0<em>Science,\u00a0<\/em>explains how researchers discovered a connection between the liver\u2019s internal clock and feeding centers in the brain.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-105994\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"799\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience.jpg\" alt=\"This shows a brain and a clock.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/liver-brain-axis-circadian-rhythm-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Cutting the nerve connection in obese mice restored normal eating patterns and reduced food intake. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The team\u2019s research showed that the liver sends signals to the brain via the vagus nerve, letting the brain know if eating is happening at a time that follows the body\u2019s circadian rhythm.<\/p>\n<p>These signals can get disrupted from working unusual hours. The brain then overcompensates, leading to overeating at the wrong times.<\/p>\n<p>\u201cBoth mice and humans normally eat at times when they are awake and alert, and this circuit provides feedback from the liver to the central clock in the brain that keeps the system running smoothly,\u201d said the study\u2019s senior author,\u00a0Mitchell Lazar, MD, PhD,\u00a0the director of Penn Medicine\u2019s Institute for Diabetes, Obesity, and Metabolism, and the Ware Professor of Diabetes and Metabolic Diseases.<\/p>\n<p>\u201cThis feedback is through a nerve connection from the liver to the brain\u201d.<\/p>\n<p>Researchers specifically targeted genes called REV-ERBs in the liver cells of mice. REV-ERBs are important proteins that help regulate the body\u2019s circadian rhythm. The body\u2019s circadian rhythm is an internal 24-hour cycle that regulates various activities including sleep-wake cycles, hormone release, and eating habits.<\/p>\n<p>When these REV-ERB genes were turned off in mice \u2014 making the liver have a faulty clock \u2014 eating patterns shifted dramatically, with more food consumed during less active times.<\/p>\n<p>The effects were reversible. Cutting the nerve connection in obese mice restored normal eating patterns and reduced food intake.<\/p>\n<p>\u201cThis suggests that targeting this liver-brain communication pathway could be a promising approach for weight management in individuals with disrupted circadian rhythms,\u201d said Lauren N. Woodie, PhD, a post-doctoral researcher in Lazar\u2019s lab.<\/p>\n<p>The research team suggests that targeting specific parts of the vagus nerve could help people who work night shifts or experience jet lag by addressing overeating caused by disrupted body clocks.<\/p>\n<p>\u201cThese findings open the door to future therapies that can target specific neural pathways to help those struggling with metabolic disorders caused by irregular eating schedules.<\/p>\n<p>\u201cFuture research should focus on what kind of chemical signals the liver sends to the vagus nerve, to help us understand how the liver affects the brain and the body through this communication.\u201d<\/p>\n<p><strong>Funding: <\/strong>The study was funded by the National Institutes of Diabetes, Digestive Diseases, and Metabolism, the JPB Foundation, and the Cox Medical Research Institute.<\/p>\n<h2 class=\"wp-block-heading\">About this circadian rhythm research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#0e636f7a7a666b79207a616f624e7e6b6060636b6a676d67606b207b7e6b6060206b6a7b\" target=\"_blank\" rel=\"noreferrer noopener\">Matthew Toal<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/pennmedicine.upenn.edu\" target=\"_blank\" rel=\"noreferrer noopener\">University of Pennsylvania<\/a><br \/><strong>Contact: <\/strong>Matthew Toal \u2013 University of Pennsylvania<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Closed access.<br \/>\u201c<a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adn2786\" target=\"_blank\" rel=\"noreferrer noopener\">Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake<\/a>\u201d by Mitchell Lazar et al. <em>Science<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake<\/strong><\/p>\n<p>Circadian desynchrony induced by shiftwork or jet lag is detrimental to metabolic health, but how synchronous or desynchronous signals are transmitted among tissues is unknown.<\/p>\n<p>We report that liver molecular clock dysfunction is signaled to the brain through the hepatic vagal afferent nerve (HVAN), leading to altered food intake patterns that are corrected by ablation of the HVAN.<\/p>\n<p>Hepatic branch vagotomy also prevents food intake disruptions induced by high-fat diet feeding and reduces body weight gain.<\/p>\n<p>Our findings reveal a homeostatic feedback signal that relies on communication between the liver and the brain to control circadian food intake patterns.<\/p>\n<p>This identifies the hepatic vagus nerve as a potential therapeutic target for obesity in the setting of chronodisruption.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/liver-brain-circadian-eating-28002\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: A new study highlights how signals from the liver to the brain influence eating patterns tied to our circadian rhythms. This liver-brain communication can become disrupted in people working &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=124100\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-124100","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/124100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=124100"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/124100\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=124100"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=124100"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=124100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}