{"id":124698,"date":"2024-11-11T19:31:48","date_gmt":"2024-11-11T12:31:48","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=124698"},"modified":"2024-11-11T19:31:48","modified_gmt":"2024-11-11T12:31:48","slug":"alzheimers-brain-timeline-shift-trickle-torrent-shots-health-news-npr","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=124698","title":{"rendered":"Alzheimer\u2019s-brain-timeline-shift-trickle-torrent : Shots &#8211; Health News : NPR"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div id=\"storytext\">\n<div id=\"resg-s1-33644\" class=\"bucketwrap image large\">\n<div class=\"imagewrap has-source-dimensions\" data-crop-type=\"\" style=\"&#10;        --source-width: 2308;&#10;        --source-height: 1298;&#10;    \">\n        <picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2308x1298+0+0\/resize\/1100\/quality\/85\/format\/webp\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fda%2Fde%2F67ab43aa480686bc27e27961afb9%2Fgettyimages-1328955938.jpg\" class=\"img\" type=\"image\/webp\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2308x1298+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fda%2Fde%2F67ab43aa480686bc27e27961afb9%2Fgettyimages-1328955938.jpg\" data-format=\"webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2308x1298+0+0\/resize\/1100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fda%2Fde%2F67ab43aa480686bc27e27961afb9%2Fgettyimages-1328955938.jpg\" class=\"img\" type=\"image\/jpeg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2308x1298+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fda%2Fde%2F67ab43aa480686bc27e27961afb9%2Fgettyimages-1328955938.jpg\" data-format=\"jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2308x1298+0+0\/resize\/1100\/quality\/85\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fda%2Fde%2F67ab43aa480686bc27e27961afb9%2Fgettyimages-1328955938.jpg\" class=\"img\" alt=\"Scientists have found one type of neuron is affected early in Alzheimer's.\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/2308x1298+0+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fda%2Fde%2F67ab43aa480686bc27e27961afb9%2Fgettyimages-1328955938.jpg\" data-format=\"jpeg\"\/>\n        <\/picture>\n<\/div>\n<div class=\"credit-caption\">\n<div class=\"caption-wrap\">\n<div class=\"caption\" aria-label=\"Image caption\">\n<p>\n                Scientists have found one type of neuron is affected early in Alzheimer&#8217;s.<br \/>\n                <b class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>                    koto_feja\/Getty Images\/E+<\/p>\n<p>                <\/b><br \/>\n                <b class=\"hide-caption\"><b>hide caption<\/b><\/b>\n            <\/p>\n<\/p><\/div>\n<p>            <b class=\"toggle-caption\"><b>toggle caption<\/b><\/b>\n    <\/div>\n<p>    <span class=\"credit\" aria-label=\"Image credit\"><\/p>\n<p>        koto_feja\/Getty Images\/E+<\/p>\n<p>    <\/span>\n<\/div>\n<\/p><\/div>\n<p>A study of cells from 84 cadaver brains suggests that Alzheimer\u2019s has two distinct phases, and that one type of neuron is especially vulnerable.<\/p>\n<p>\u201cThere\u2019s an early phase where there\u2019s a very slow increase in the amount of pathology,\u201d says <a href=\"https:\/\/alleninstitute.org\/person\/ed-lein\/\">Ed Lein<\/a>, a senior investigator at the Allen Institute for Brain Science in Seattle, \u201cthen a more exponential phase where suddenly things get really bad.\u201d<\/p>\n<p>The study also found evidence that a small subset of neurons known as <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5635659\/#:~:text=Somatostatin%2Dexpressing%20GABAergic%20neurons%20constitute,the%20absence%20of%20synaptic%20input.\">somatostatin inhibitory neurons<\/a> begin to die off during the early phase of Alzheimer\u2019s, Lein and a team of nearly 100 other scientists <a href=\"https:\/\/www.nature.com\/articles\/s41593-024-01774-5\">report<\/a> in the journal <em>Nature Neuroscience<\/em>.<\/p>\n<aside id=\"ad-backstage-wrap\" class=\"ad-wrap backstage\" aria-label=\"advertisement\">\n<\/aside>\n<p>\u201cThat was quite a surprise,\u201d Lein says, because these neurons have received relatively little attention from Alzheimer\u2019s researchers.<\/p>\n<p>The findings suggest that Alzheimer\u2019s treatments are most likely to help early in the disease, and that one strategy might be to protect vulnerable inhibitory neurons.<\/p>\n<p>The results also show how scientists\u2019 understanding of Alzheimer\u2019s is being changed by new tools and techniques that can reveal detailed information about millions of individual brain cells.<\/p>\n<p>\u201cThey\u2019ve produced a picture of what\u2019s going on that no one could have anticipated just a few years ago,\u201d says <a href=\"https:\/\/www.nia.nih.gov\/about\/staff\/hodes-richard\">Dr. Richard Hodes<\/a>, who directs the National Institute on Aging, which played a key role in funding the research.<\/p>\n<h3 class=\"edTag\">Tracking brain cell changes<\/h3>\n<div id=\"resnx-s1-5183228-100\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImageg-s1-13519\" href=\"https:\/\/www.npr.org\/sections\/shots-health-news\/2024\/07\/29\/g-s1-13519\/alzheimers-protein-reelin-brain-aging-amyloid-tau-memory\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\\\/\\\/www.npr.org\\\/sections\\\/shots-health-news\\\/2024\\\/07\\\/29\\\/g-s1-13519\\\/alzheimers-protein-reelin-brain-aging-amyloid-tau-memory&quot;}\"><picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/100\/quality\/15\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/100\/quality\/15\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/3412x3412+853+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2F93%2F6b%2Fd3a8246645ac981568673fac0b33%2Fgettyimages-512298231.jpg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"A key protein called Reelin may help stave off Alzheimer's disease, according to a growing body of research.\" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5183228-100\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>The study looked at more than 3.4 million cells from the brains of people who died at age 65 or older. Some had healthy brains, while others were in various stages of Alzheimer\u2019s.<\/p>\n<p>The team focused on an area called the middle temporal gyrus, which is involved in language, memory, and vision.<\/p>\n<p>By comparing cells taken at different stages of Alzheimer\u2019s, scientists were able to create a timeline showing how the disease alters the brain.<\/p>\n<p>\u201cWe measure all the genes in each individual cell,\u201d Lien says. \u201cThat allows you to not only identify those cells, but look for changes in those cells as a result of disease.\u201d<\/p>\n<aside id=\"ad-secondary-wrap\" class=\"ad-wrap secondary\" aria-label=\"advertisement\">\n<\/aside>\n<p>Some of the changes confirmed earlier research. For example, cells related to immune function in the brain became more active.<\/p>\n<p>Lein says artificial intelligence and new imaging and genetic techniques allowed the team to search for other changes that previously would have gone undetected.<\/p>\n<p>\u201cWe were looking for vulnerable cell populations, for example particular types of neurons that might be specifically lost early in disease,\u201d Lein says.<\/p>\n<p>The team had expected to find changes to excitatory neurons, which form connections to distant areas of the brain and act like the accelerator in a car by encouraging other neurons to fire.<\/p>\n<p>\u201cBut it turns out that the first cells lost are actually some of the inhibitory neurons,\u201d Lien says.<\/p>\n<p>Inhibitory neurons act like the brake in a car by forming connections with nearby excitatory neurons and controlling their activity.<\/p>\n<div id=\"resnx-s1-5183228-101\" class=\"bucketwrap internallink insettwocolumn inset2col \">\n<div class=\"bucket img\">\n                  <a class=\"imagewrap\" id=\"featuredStackSquareImagenx-s1-5124734\" href=\"https:\/\/www.npr.org\/2024\/10\/02\/nx-s1-5124734\/fruit-fly-brain-connectome-neurons\" data-metrics-ga4=\"{&quot;category&quot;:&quot;recirculation&quot;,&quot;action&quot;:&quot;story_recirculation_click&quot;,&quot;clickType&quot;:&quot;inset box&quot;,&quot;clickUrl&quot;:&quot;https:\\\/\\\/www.npr.org\\\/2024\\\/10\\\/02\\\/nx-s1-5124734\\\/fruit-fly-brain-connectome-neurons&quot;}\"><picture><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/100\/quality\/15\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-format=\"webp\" class=\"img lazyOnLoad\" type=\"image\/webp\"\/><source srcset=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/100\/quality\/15\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-original=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" type=\"image\/jpeg\"\/><img decoding=\"async\" src=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/100\/quality\/100\/format\/jpeg\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-template=\"https:\/\/npr.brightspotcdn.com\/dims3\/default\/strip\/false\/crop\/1080x1080+420+0\/resize\/{width}\/quality\/{quality}\/format\/{format}\/?url=http%3A%2F%2Fnpr-brightspot.s3.amazonaws.com%2Fac%2F78%2F3dcc077d43509dcfd979342bd381%2F2.jpeg\" data-format=\"jpeg\" class=\"img lazyOnLoad\" alt=\"The fruit fly connectome contains a wide range of information, from cell types and synapses to neurotransmitters and network properties. Here, cells are color-coded by their defining chemical messenger. \" loading=\"lazy\"\/><\/picture><\/a>         <\/p>\n<p><!-- END CLASS=\"BUCKETBLOCK\" -->\n      <\/div>\n<p><!-- END CLASS=\"BUCKET IMG\" -->\n   <\/div>\n<p><!-- END ID=\"RESNX-S1-5183228-101\" CLASS=\"BUCKETWRAP INTERNALLINK INSETTWOCOLUMN INSET2COL \" --><\/p>\n<p>The specific type of inhibitory neurons that appear to die off early in Alzheimer\u2019s release a chemical messenger called somatostatin, which is known to decline in Alzheimer\u2019s patients.<\/p>\n<p>Somatostatin neurons help control the activity of brain networks involved in memory and thinking.<\/p>\n<p>Any decline in these cells could upset the delicate balance between inhibitory and excitatory neurons in the brain. Epilepsy and some other brain disorders are thought to be the result of an imbalance.<\/p>\n<p>\u201cIt could be that the loss of these [somatostatin] inhibitory neurons is causing a hyper-excitatory state which may be contributing to disease,\u201d Hodes says.<\/p>\n<p>If that\u2019s the case, Hodes says, treatment would need to start before too many inhibitory neurons are lost. And the new study suggests that may be possible,<\/p>\n<p>\u201cThe fact that there is a process early on that is slow is an inviting opportunity to intervene,\u201d he says.<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.npr.org\/sections\/shots-health-news\/2024\/11\/10\/nx-s1-5183228\/alzheimers-timeline-shows-changes-start-as-trickle-become-torrent\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have found one type of neuron is affected early in Alzheimer&#8217;s. koto_feja\/Getty Images\/E+ hide caption toggle caption koto_feja\/Getty Images\/E+ A study of cells from 84 cadaver brains suggests that &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=124698\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-124698","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/124698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=124698"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/124698\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=124698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=124698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=124698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}