{"id":125640,"date":"2024-11-14T06:33:53","date_gmt":"2024-11-13T23:33:53","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=125640"},"modified":"2024-11-14T06:33:53","modified_gmt":"2024-11-13T23:33:53","slug":"study-revolutionize-restless-legs-syndrome-treatment","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=125640","title":{"rendered":"Study Revolutionize Restless Legs Syndrome Treatment"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers released new clinical guidelines for treating restless legs syndrome (RLS), emphasizing patient-centered care and evidence-based updates. Iron supplementation is now a key recommendation, addressing low brain iron as a cause of RLS.<\/p>\n<p>Dopamine agonists like pramipexole and ropinirole are de-emphasized due to risks of worsening symptoms, while newer treatments such as alpha-2-delta ligands, nerve stimulation, and low-dose opioids gain conditional or strong recommendations. Innovative options like peroneal nerve stimulation and gabapentin are highlighted for their effectiveness without the augmentation risks seen with older medications.<\/p>\n<p>The guidelines also stress addressing lifestyle factors like caffeine and untreated sleep apnea to optimize RLS management. These updates reflect a decade of advancements and aim to improve treatment outcomes for millions affected by RLS.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Iron supplementation is a primary recommendation for addressing low brain iron in RLS patients.<\/li>\n<li>Dopaminergic agents are now discouraged due to risks of symptom worsening over time.<\/li>\n<li>New treatments, including gabapentin and nerve stimulation, are supported for better efficacy and fewer side effects.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>AASM<\/p>\n<p><strong>A new clinical practice guideline developed by the American Academy of Sleep Medicine provides updated recommendations for the\u00a0treatment of restless legs syndrome. The guideline reflects the latest scientific evidence and recommends significant changes in the standard treatment of RLS in adults.<\/strong><\/p>\n<p>Available online as an accepted paper in the\u00a0<em>Journal of Clinical Sleep Medicine<\/em>,\u00a0the guideline updates the AASM\u2019s previous guidance published in 2012. The authors noted that numerous clinical trials and longitudinal studies have been conducted in the last decade, contributing vital evidence that supports these new recommendations.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106165\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology.jpg\" alt=\"This shows a man sitting awake in bed.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/rls-treatment-neurology-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The authors advised that the first step in the management of RLS should be to address exacerbating factors including alcohol, caffeine, certain antidepressant and antihistamine medications, and untreated obstructive sleep apnea. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cThis new clinical practice guideline from the AASM represents an important turning point in the treatment of RLS in adults,\u201d said Dr. John Winkelman, chair of the AASM task force, professor of psychiatry at Harvard Medical School, and chief of the sleep disorders clinical research program at Massachusetts General Hospital.<\/p>\n<p>\u201cGuided by the best evidence in the scientific literature, we\u2019ve provided recommendations that will improve the ability of clinicians to provide patient-centered care for people who have RLS.\u201d<\/p>\n<p>RLS is a sleep-related movement disorder\u00a0characterized by a strong, nearly irresistible urge to move the legs, which is often accompanied by other uncomfortable sensations felt in the legs.<\/p>\n<p>These symptoms begin or worsen during periods of rest or inactivity, are temporarily or totally relieved by movement, and occur exclusively or predominantly in the evening or at night. RLS can cause sleep disturbance, distress, and impairment in functioning.<\/p>\n<p>One of the significant changes in the new guideline is that it elevates the importance of iron evaluation in everyone with RLS and, depending on iron indices, recommends iron supplementation.<\/p>\n<p>These recommendations reflect evidence suggesting that low brain iron is an important underlying cause of RLS. For adults with RLS, the guideline provides a strong recommendation for intravenous ferric carboxymaltose and conditional recommendations for two other formulations of intravenous iron and one formulation of oral iron \u2014 ferrous sulfate.<\/p>\n<p>For children with RLS, ferrous sulfate received a conditional recommendation, making it the only treatment recommended for pediatric patients.<\/p>\n<p>A \u201cstrong\u201d recommendation is one that clinicians should follow under most circumstances. A \u201cconditional\u201d recommendation reflects a lower degree of certainty and requires the clinician to use clinical judgment and consider the patient\u2019s values and preferences to determine the best course of action.<\/p>\n<p>Another important change is that the new guideline includes conditional recommendations\u00a0<em>against<\/em>\u00a0the standard use of pramipexole and ropinirole, both of which were supported by strong recommendations in the 2012 guidance.<\/p>\n<p>Research published in the last 10 years has clarified that the long-term use of these dopamine agonists and other dopaminergic medications is often associated with the risk of \u201caugmentation,\u201d which is the gradual worsening of RLS symptom intensity and duration.<\/p>\n<p>In contrast, new evidence supporting three alpha-2-delta ligand calcium channel blockers \u2014 gabapentin enacarbil, gabapentin, and pregabalin \u2014 led the task force to support them as strong recommendations for RLS treatment. These medications are not associated with the augmentation of RLS symptoms observed with the dopaminergic agents.<\/p>\n<p>Bilateral high-frequency peroneal nerve stimulation, an innovative treatment developed in the years since the previous guidance was published, received a conditional recommendation of support. Treatment involves the use of a wearable device to stimulate the nerves in the legs before bedtime.<\/p>\n<p>The use of low-dose, extended-release oxycodone and other low-dose opioids also received conditional recommendations of support. The authors noted that low-dose opioids have demonstrated efficacy for RLS, but opioids also have risks that require cautious use and clinical oversight.<\/p>\n<p>A\u00a0national RLS opioid registry\u00a0based at Massachusetts General Hospital continues to collect longitudinal data to assess the long-term safety, dose stability, and efficacy of opioid medications for RLS.<\/p>\n<p>The authors advised that the first step in the management of RLS should be to address exacerbating factors including alcohol, caffeine, certain antidepressant and antihistamine medications, and untreated obstructive sleep apnea. They also noted that RLS is common in pregnancy.<\/p>\n<p>To develop the guideline, the AASM commissioned a task force of sleep medicine clinicians with expertise in RLS.<\/p>\n<p>They crafted 28 clinical practice recommendations based on a systematic review of the literature and an assessment of the evidence according to the GRADE process, taking into consideration the quality of evidence, beneficial and harmful effects, patient values and preferences, and resource use.<\/p>\n<h2 class=\"wp-block-heading\">About this restless leg syndrome research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#1f727a7b767e5f7e7e6c7231706d78\" target=\"_blank\" rel=\"noreferrer noopener\">Thomas Heffron<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/aasm.org\" target=\"_blank\" rel=\"noreferrer noopener\">AASM<\/a><br \/><strong>Contact: <\/strong>Thomas Heffron \u2013 AASM<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/jcsm.aasm.org\/doi\/10.5664\/jcsm.11390\" target=\"_blank\" rel=\"noreferrer noopener\">Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline<\/a>\u201d by John Winkelman et al. <em><em>Journal of Clinical Sleep Medicine<\/em><\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline<\/strong><\/p>\n<h3 class=\"wp-block-heading\" id=\"d1e387\">Introduction:<\/h3>\n<p>This guideline establishes clinical practice recommendations for Treatment of Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD) in adults and pediatric patients.<\/p>\n<h3 class=\"wp-block-heading\" id=\"d1e394\">Methods:<\/h3>\n<p>The American Academy of Sleep Medicine (AASM) commissioned a task force of experts in sleep medicine to develop recommendations and assign strengths based on a systematic review of the literature and an assessment of the evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. The task force provided a summary of the relevant literature and the certainty of evidence, the balance of benefits and harms, patient values and preferences, and resource use considerations that support the recommendations. The AASM Board of Directors approved the final recommendations<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/restless-legs-syndrome-treatment-28044\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers released new clinical guidelines for treating restless legs syndrome (RLS), emphasizing patient-centered care and evidence-based updates. Iron supplementation is now a key recommendation, addressing low brain iron as &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=125640\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-125640","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/125640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=125640"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/125640\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=125640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=125640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=125640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}