{"id":126583,"date":"2024-11-16T17:32:08","date_gmt":"2024-11-16T10:32:08","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=126583"},"modified":"2024-11-16T17:32:08","modified_gmt":"2024-11-16T10:32:08","slug":"cannabis-really-can-induce-sleep-and-now-we-know-why-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=126583","title":{"rendered":"Cannabis Really Can Induce Sleep, And Now We Know Why : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Scientists have confirmed the cannabis ingredient <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabinol\">cannabinol<\/a> (CBN) can increase sleep in rats, highlighting a new path for future sleep treatments in humans.<\/p>\n<p>Researchers from the University of Sydney found a break-down product of the compound extends periods of both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in rats, comparable to the effects of a popular sleep aid.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Both stages of sleep are critical in maintaining physical and mental health. REM, also considered the dream stage, helps with <a href=\"https:\/\/www.sciencealert.com\/study-on-mice-shows-how-sleep-can-help-the-brain-regulate-emotions\">processing emotions<\/a>, while non-REM sleep is associated with <a href=\"https:\/\/www.sleepfoundation.org\/stages-of-sleep\/nrem-sleep\">essential body repairs<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While purified CBN products are sold as a sleep medication in the US, robust evidence backing up its restful benefits had been lacking until now. The study&#8217;s results set the foundation for future research into how the compound could help treat <a href=\"https:\/\/www.sciencealert.com\/when-nothing-seems-to-help-you-fall-asleep-try-these-suggestions\">sleep disorders<\/a>.<\/p>\n<figure id=\"attachment_143370\" aria-describedby=\"caption-attachment-143370\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/SleepyRat.jpg\" alt=\"Cannabis effects diagram\" width=\"642\" height=\"342\" class=\"wp-image-143370 size-full\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/SleepyRat.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/SleepyRat-600x320.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-143370\" class=\"wp-caption-text\">CBN boosted sleep in rats. (University of Sydney)<\/figcaption><\/figure>\n<p>&#8220;For decades, cannabis folklore has suggested that aged cannabis makes consumers sleepy via the build-up of CBN,&#8221; <a href=\"https:\/\/www.sydney.edu.au\/news-opinion\/news\/2024\/11\/12\/cannabinol-increases-sleep-objective-measure-lambert.html\">says<\/a> pharmacologist Jonathon Arnold.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Our study provides the first objective evidence that CBN increases sleep, at least in rats, by modifying the architecture of sleep in a beneficial way.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The main psychoactive element in cannabis, delta9-tetrahydrocannabinol or THC, slowly forms CBN in the plant when exposed to heat, oxygen, and light.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While THC has an intoxicating effect on the brain&#8217;s <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabinoid_receptor_1\">CB1 cannabinoid receptors<\/a>, the influence of CBN was far weaker, the researchers found.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>In fact, through a closer look at brain activity, the team discovered that the metabolite 11-hydroxy-CBN \u2013 produced by the breakdown of CBN in the animals \u2013 has a stronger effect on the CB1 cannabinoid receptors than CBN itself.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Given the importance of these brain receptors in <a href=\"https:\/\/www.sciencealert.com\/humans-used-to-sleep-in-two-shifts-maybe-we-should-again\">managing sleep<\/a>, it&#8217;s likely CBN&#8217;s metabolites may have a more significant influence on sleep than than CBN itself.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;It was a surprise that CBN metabolism in the body can yield a much greater effect on cannabinoid CB1 receptors than the parent molecule CBN, which has much more limited activity,&#8221; <a href=\"https:\/\/www.sydney.edu.au\/news-opinion\/news\/2024\/11\/12\/cannabinol-increases-sleep-objective-measure-lambert.html\">says<\/a> Arnold.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Medications containing CBN might aid sleep with relatively few side effects on other parts of the brain, though this possibility still needs to be investigated. Human  <a href=\"https:\/\/www.sciencealert.com\/clinical-trials\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73032\" data-postid=\"143793\" rel=\"nofollow noopener\" target=\"_self\">clinical trials<\/a> are already underway in patients <a href=\"https:\/\/www.sciencealert.com\/doing-this-one-thing-makes-insomnia-even-worse-psychologists-warn\">with insomnia<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;At this stage our results are confined to testing in rats,&#8221; <a href=\"https:\/\/www.sydney.edu.au\/news-opinion\/news\/2024\/11\/12\/cannabinol-increases-sleep-objective-measure-lambert.html\">says<\/a> Arnold. &#8220;Further research is needed to see if this translates to humans.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Our research encourages further basic and clinical research on CBN as a new treatment strategy for sleep disorders, including insomnia.&#8221;<\/p>\n<p>The research has been published in <a href=\"https:\/\/www.nature.com\/articles\/s41386-024-02018-7\"><em>Neuropsychopharmacology<\/em><\/a>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/cannabis-really-can-induce-sleep-and-now-we-know-why\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have confirmed the cannabis ingredient cannabinol (CBN) can increase sleep in rats, highlighting a new path for future sleep treatments in humans. Researchers from the University of Sydney found &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=126583\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-126583","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=126583"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126583\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=126583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=126583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=126583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}