{"id":126780,"date":"2024-11-17T05:44:45","date_gmt":"2024-11-16T22:44:45","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=126780"},"modified":"2024-11-17T05:44:45","modified_gmt":"2024-11-16T22:44:45","slug":"how-depression-alters-stress-health-and-lifespan","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=126780","title":{"rendered":"How Depression Alters Stress, Health, and Lifespan"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Depression disrupts the body\u2019s stress systems, causing physical health risks like heart disease, diabetes, and stroke, and reducing life expectancy by 7-10 years. The condition triggers brain structure changes, such as a 40% reduction in subgenual prefrontal cortex volume, and disrupts hormone systems involving CRH, norepinephrine, and cortisol.<\/p>\n<p>Different subtypes of depression, such as melancholic and atypical, show distinct stress responses, suggesting a need for personalized treatments. These findings open new pathways for therapies targeting neuroendocrine dysfunction to improve outcomes for depressive illnesses.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>Depression shortens life expectancy by up to 10 years due to stress system disruptions.<\/li>\n<li>It reduces subgenual prefrontal cortex volume by 40% and alters hormone pathways.<\/li>\n<li>Personalized treatments could emerge from targeting neuroendocrine dysfunction.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Genomic Press<\/p>\n<p><strong>A landmark paper by distinguished neuroendocrine psychiatrist Dr. Philip W. Gold, published in\u00a0<em>Brain Medicine<\/em>\u2018s Seymour Reichlin Centenary Festschrift collection, presents a masterful synthesis of how depression fundamentally alters the body\u2019s stress response systems, challenging long-held views of the condition.<\/strong><\/p>\n<p>The Viewpoint Review, published online November 14, 2024, represents a culmination of Dr. Gold\u2019s pioneering work in neuroendocrine psychiatry and honors the centenary of Dr. Seymour Reichlin, a foundational figure in neuroendocrinology whose work influenced generations of researchers.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106242\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience.jpg\" alt=\"This shows a head.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/depression-stress-lifespan-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The combined effects of CRH, norepinephrine, cortisol, and inflammatory pathways help explain why depression often leads to early onset of various illnesses and a shortened lifespan for those affected. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cDepression\u2019s toll reaches beyond mood and thought, extending into physical health risks like coronary artery disease, diabetes, osteoporosis, and stroke,\u201d explains Dr. Gold, documenting how these conditions collectively reduce life expectancy by approximately 7 to 10 years in affected individuals.<\/p>\n<p>His analysis reveals striking brain structure changes in depressed patients, including a 40% reduction in subgenual prefrontal cortex volume\u2014a crucial region for stress response regulation. These structural changes occur alongside disruptions in multiple hormone systems, particularly involving corticotropin-releasing hormone (CRH) and norepinephrine.<\/p>\n<p>\u201cThe combined effects of CRH, norepinephrine, cortisol, and inflammatory pathways help explain why depression often leads to early onset of various illnesses and a shortened lifespan for those affected,\u201d notes Dr. Gold, emphasizing the interconnected nature of these systems.<\/p>\n<p>Dr. Gold\u2019s work draws important distinctions between depression subtypes. While melancholic depression shows heightened stress system activation, atypical depression presents with lower CRH secretion and cortisol levels, suggesting different underlying biological mechanisms requiring distinct treatment approaches.<\/p>\n<p>This understanding opens new therapeutic possibilities. The paper points toward innovative treatments targeting neuroendocrine dysfunction, including CRH antagonists, IRS p53 agonists, and hormone receptor modulators, potentially offering more effective options for managing depressive illness.<\/p>\n<p>The findings raise intriguing questions about personalized treatment approaches: Could measuring neuroendocrine markers help predict which patients will respond best to specific antidepressants? How might early intervention in these hormone systems prevent both psychological symptoms and physical health complications?<\/p>\n<p>This contribution to the Reichlin Festschrift represents a fitting tribute to both scientists\u2019 legacies in advancing our understanding of neuroendocrine systems and their impact on human health.<\/p>\n<p>The Viewpoint Review titled \u201cIs depression a neuroendocrine disease?\u201d is available on 14 November 2024 in\u00a0<em>Brain Medicine<\/em>, accompanied by a detailed figure mapping the complex interactions between brain structure, neuroendocrine systems, and clinical manifestations in depression.\u00a0<\/p>\n<h2 class=\"wp-block-heading\">About this depression and longevity research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#9ef3fff2f7b0e9f1f0f9def9fbf0f1f3f7fdeeecfbededb0fdf1f3\" target=\"_blank\" rel=\"noreferrer noopener\">Ma-Li Wong<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/genomicpress.com\" target=\"_blank\" rel=\"noreferrer noopener\">Genomic Press<\/a><br \/><strong>Contact: <\/strong>Ma-Li Wong \u2013 Genomic Press<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/bm.genomicpress.com\/wp-content\/uploads\/2024\/11\/BM0106-Gold-2024.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Is depression a neuroendocrine disease?<\/a>\u201d by Philip W. Gold et al. <em>Brain Medicine<\/em><\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/depression-stress-longevity-28066\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Depression disrupts the body\u2019s stress systems, causing physical health risks like heart disease, diabetes, and stroke, and reducing life expectancy by 7-10 years. The condition triggers brain structure changes, &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=126780\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-126780","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=126780"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126780\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=126780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=126780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=126780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}