{"id":126908,"date":"2024-11-17T13:52:55","date_gmt":"2024-11-17T06:52:55","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=126908"},"modified":"2024-11-17T13:52:55","modified_gmt":"2024-11-17T06:52:55","slug":"when-your-muscles-work-out-they-help-neurons-grow-and-heal-4x-faster-mit-study-shows","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=126908","title":{"rendered":"When Your Muscles Work Out, They Help Neurons Grow and Heal 4x Faster, MIT Study Shows"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<figure id=\"attachment_211717\" aria-describedby=\"caption-attachment-211717\" style=\"width: 696px\" class=\"wp-caption aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-large wp-image-211717\" src=\"https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-1024x549.jpg\" alt=\"\" width=\"696\" height=\"373\" srcset=\"https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-1024x549.jpg 1024w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-326x175.jpg 326w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-768x412.jpg 768w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-696x373.jpg 696w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-1068x573.jpg 1068w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-783x420.jpg 783w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E-530x284.jpg 530w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/women-friends-exercise-walking-fitness-health-Natalia-Blauth-For-Unsplash-J9aeIjzAH6E.jpg 1399w\" sizes=\"(max-width: 696px) 100vw, 696px\"\/><figcaption id=\"caption-attachment-211717\" class=\"wp-caption-text\">Natalia Blauth \/ Unsplash+<\/figcaption><\/figure>\n<p>There\u2019s no doubt that exercise does a body good\u2014strengthening muscles and bolstering our bones, blood vessels, and immune system\u2014but now, MIT engineers have found that it also has benefits at the level of individual neurons.<\/p>\n<p>They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines. In the presence of these muscle-generated signals, neurons grew four times farther compared to neurons that were not exposed to myokines.<\/p>\n<p>These cellular-level experiments suggest that exercise can have a significant biochemical effect on nerve growth. Surprisingly, the researchers also found that neurons respond not only to the biochemical signals of exercise but also to its physical impacts.<\/p>\n<p>While previous studies have indicated a potential biochemical link between muscle activity and nerve growth, this is the first to show that physical effects can be just as important\u2014and the results shed light on the connection between muscles and nerves during exercise, and could inform exercise-related therapies for repairing nerves.<\/p>\n<p>\u201cNow that we know this muscle-nerve crosstalk exists, it can be useful for treating things like nerve injury, where communication between nerve and muscle is cut off,\u201d<a href=\"https:\/\/news.mit.edu\/2024\/when-muscles-work-out-they-help-neurons-grow-1112\" target=\"_blank\" rel=\"noopener\"> says Ritu Raman<\/a>, Assistant Professor of Mechanical Engineering at MIT and senior author of the study. \u201cMaybe if we stimulate the muscle, we could encourage the nerve to heal, and restore mobility to those who have lost it due to traumatic injury or neurodegenerative diseases.\u201d<\/p>\n<h2>\u201cExercise as medicine\u201d<\/h2>\n<p>In 2023, Raman and her colleagues reported that they could restore mobility in mice that had experienced a traumatic muscle injury, by first implanting muscle tissue at the site of injury, then exercising the new tissue by stimulating it repeatedly with light. Over time, they found that the exercised graft helped mice to regain their motor function, reaching activity levels comparable to those of healthy mice.<\/p>\n<p>When the researchers analyzed the graft itself, it appeared that regular exercise stimulated the grafted muscle to produce certain biochemical signals that are known to promote nerve and blood vessel growth.<\/p>\n<p><strong>POPULAR<\/strong>: <a title=\"New Study of 10,000+ People Revealed Regular Physical Activity Is Linked to Larger Healthier Brains\" href=\"https:\/\/www.goodnewsnetwork.org\/a-new-study-of-over-10000-people-revealed-regular-physical-activity-is-linked-to-larger-healthier-brains\/\" rel=\"bookmark\">New Study of 10,000+ People Revealed Regular Physical Activity Is Linked to Larger Healthier Brains<\/a><\/p>\n<figure id=\"attachment_211716\" aria-describedby=\"caption-attachment-211716\" style=\"width: 696px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-211716\" src=\"https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-1024x565.jpg\" alt=\"\" width=\"696\" height=\"384\" srcset=\"https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-1024x565.jpg 1024w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-326x180.jpg 326w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-768x423.jpg 768w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-696x385.jpg 696w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-1068x589.jpg 1068w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-762x420.jpg 762w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT-530x292.jpg 530w, https:\/\/www.goodnewsnetwork.org\/wp-content\/uploads\/2024\/11\/After-exercise-motor-neurons-purple-exhibit-new-growth-green-faster-Credit\u2013Angel-Bu-released-by-MIT.jpg 1400w\" sizes=\"auto, (max-width: 696px) 100vw, 696px\"\/><figcaption id=\"caption-attachment-211716\" class=\"wp-caption-text\">After exercise, motor neurons (purple) exhibit new growth (green) faster than without exercise \u2013 Credit: Angel Bu \/ MIT<\/figcaption><\/figure>\n<p>\u201cWe always think that nerves control muscle, but we don\u2019t think of muscles talking back to nerves,\u201d Raman says. \u201cSo, we started to think stimulating muscle was encouraging nerve growth. And people replied that maybe that\u2019s the case, but there\u2019s hundreds of other cell types in an animal, and it\u2019s really hard to prove that the nerve is growing more because of the muscle, rather than the immune system or something else playing a role.\u201d<\/p>\n<p>In their <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202403712\" target=\"_blank\" rel=\"noopener\">new study published in<\/a> the journal Advanced Healthcare Materials, the team set out to determine whether exercising muscles has direct effect on how nerves grow, by focusing solely on muscle and nerve tissue.<\/p>\n<p>The team genetically modified the muscle to contract in response to light. With this modification, the team could flash a light repeatedly, causing the muscle to squeeze in response, in a way that mimicked the act of exercise. Raman previously developed a novel gel mat on which to grow and exercise muscle tissue. The gel\u2019s properties are such that it can support muscle tissue and prevent it from peeling away as the researchers stimulated the muscle to exercise.<\/p>\n<p><strong>GROWS YOUR BRAIN:<\/strong> <a title=\"New Study of 10,000+ People Revealed Regular Physical Activity Is Linked to Larger Healthier Brains\" href=\"https:\/\/www.goodnewsnetwork.org\/a-new-study-of-over-10000-people-revealed-regular-physical-activity-is-linked-to-larger-healthier-brains\/\" rel=\"bookmark\">New Study of 10,000+ People Revealed Regular Physical Activity Is Linked to Larger Healthier Brains<\/a><\/p>\n<p>The team then collected samples of the surrounding solution in which the muscle tissue was exercised, thinking that the solution should hold myokines, including growth factors, RNA, and a mix of other proteins.<\/p>\n<p>\u201cMuscles are pretty much always secreting myokines, but when you exercise them, they make more,\u201d Raman says.<\/p>\n<p>The researchers grew the neurons from stem cells derived from mice. As with the muscle tissue, the neurons were grown on a similar gel mat. After the neurons were exposed to the myokine mixture, the team observed that they quickly began to grow\u2014four times faster than neurons that did not receive the biochemical solution.<\/p>\n<p>\u201cThey grow much farther and faster, and the effect is pretty immediate,\u201d Raman notes.<\/p>\n<p>For a closer look at how neurons changed in response to the exercise-induced myokines, the team ran a genetic analysis, extracting RNA from the neurons to see whether the myokines induced any change in the expression of certain neuronal genes.<\/p>\n<p><strong>ALSO GREAT FOR DEPRESSION AND THE HEART:<\/strong> <a title=\"Exercise Cuts Heart Disease Risk by 23% With Benefits Doubling for Those With Depression\" href=\"https:\/\/www.goodnewsnetwork.org\/exercise-cuts-heart-disease-risk-by-23-with-benefits-doubling-for-those-with-depression\/\" rel=\"bookmark\">Exercise Cuts Heart Disease Risk by 23% With Benefits Doubling for Those With Depression<\/a><\/p>\n<p>\u201cWe saw that many of the genes up-regulated in the exercise-stimulated neurons was not only related to neuron growth, but also neuron maturation, how well they talk to muscles and other nerves, and how mature the axons are,\u201d Raman says. \u201cExercise seems to impact not just neuron growth but also how mature and well-functioning they are.\u201d<\/p>\n<p>The results suggest that biochemical effects of exercise can promote neuron growth. Then the group wondered: Could exercise\u2019s purely physical impacts have a similar benefit?<\/p>\n<p>\u201cNeurons are physically attached to muscles, so they are also stretching and moving with the muscle,\u201d Raman says. \u201cWe also wanted to see, even in the absence of biochemical cues from muscle, could we stretch the neurons back and forth, mimicking the mechanical forces (of exercise), and could that have an impact on growth as well?\u201d<\/p>\n<p>It turned out that both biochemical and physical effects of exercise are \u201cequally important\u201d.<\/p>\n<p><strong>GET WALKING:<\/strong> <a title=\"Millions Who Suffer Back Pain Can Ease Symptoms Simply by Walking More\u2013For \u2018Huge Benefits\u2019\" href=\"https:\/\/www.goodnewsnetwork.org\/millions-who-suffer-back-pain-can-ease-symptoms-simply-by-walking-more-for-huge-benefits\/\" rel=\"bookmark\">Millions Who Suffer Back Pain Can Ease Symptoms Simply by Walking More\u2013For \u2018Huge Benefits\u2019<\/a><\/p>\n<p>Now that the group has shown that exercising muscle can promote nerve growth at the cellular level, they plan to study how targeted muscle stimulation can be used to grow and heal damaged nerves, and restore mobility for people who are living with a neurodegenerative disease such as ALS.<\/p>\n<p>\u201cThis is just our first step toward understanding and controlling exercise as medicine,\u201d Raman says.<\/p>\n<p><strong>SHARE THE NEWS With Fitness Gurus On Social Media\u2026<\/strong><\/p>\n<\/p><\/div>\n<p><script type=\"text\/javascript\">!function(f,b,e,v,n,t,s)\n{if(f.fbq)return;n=f.fbq=function(){n.callMethod?\nn.callMethod.apply(n,arguments):n.queue.push(arguments)};\nif(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';\nn.queue=[];t=b.createElement(e);t.async=!0;\nt.src=v;s=b.getElementsByTagName(e)[0];\ns.parentNode.insertBefore(t,s)}(window,document,'script',\n'https:\/\/connect.facebook.net\/en_US\/fbevents.js');\n fbq('init', '1923853574557163'); \nfbq('track', 'PageView');\n<\/script><br \/>\n<br \/><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.goodnewsnetwork.org\/when-your-muscles-work-out-they-help-neurons-grow-and-heal-4x-faster-mit-study-shows\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Natalia Blauth \/ Unsplash+ There\u2019s no doubt that exercise does a body good\u2014strengthening muscles and bolstering our bones, blood vessels, and immune system\u2014but now, MIT engineers have found that it &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=126908\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-126908","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=126908"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126908\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=126908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=126908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=126908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}