{"id":126983,"date":"2024-11-17T18:58:49","date_gmt":"2024-11-17T11:58:49","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=126983"},"modified":"2024-11-17T18:58:49","modified_gmt":"2024-11-17T11:58:49","slug":"long-covid-may-be-far-more-common-than-previously-known","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=126983","title":{"rendered":"Long COVID may be far more common than previously known"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Though the pandemic hit hardest in communities of color where residents had high rates of preexisting conditions and many held service industry jobs that placed them at high risk of contracting the virus, the vast majority of those diagnosed with long COVID are white, non-Hispanic females who live in affluent communities and have greater access to healthcare, he said.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Moreover, many of the patients who receive a long COVID diagnosis concluded on their own that they have the condition and then persuaded their doctors to look into it, he said. As a result, the available statistics we have both underestimate the true number of patients suffering from the condition and skew it to a specific demographic.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">\u201cNot all people even know that their condition might be caused or exacerbated by COVID,\u201d Estiri said. \u201cSo those who go and get a diagnosis represent a small proportion of the population.\u201d<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Diagnosis is complicated by the fact that long COVID can cause hundreds of different symptoms, many of which are difficult to describe or are easily dismissed, such as sleep problems, headaches or generalized pain, Estiri said. According to its formal<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMsb2408466\"> definition<\/a>, long COVID occurs after a COVID-19 infection, lasts for at least three months, affects one or more organ systems, and includes a broad range of symptoms such as crushing fatigue, pain, and a racing heart rate.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">The US Centers for Disease Control and Prevention suggested that in 2022 roughly 6.9 percent of Americans had long COVID. But the algorithm developed by Estiri\u2019s team estimated that 22.8 percent of those who\u2019d tested positive for COVID-19 met the diagnostic criteria for long COVID in the 12 months that followed, even though the vast majority had not received an official diagnosis.<\/span><\/p>\n<div id=\"\" class=\"image | relative margin_bottom_16&#10;          margin_top width_full&#10;          false&#10;          false&#10;          \">\n<figure class=\"font_primary false&#10;               false&#10;              false&#10;            \" style=\"height:auto\" id=\"img-BEY274ILODLVHBLPVSLCQ5UXNE\"><img decoding=\"async\" id=\"img-BEY274ILODLVHBLPVSLCQ5UXNE-image\" alt=\"(from left) Shawn Murphy, chief research information officer, Hossein Estiri, head of AI Research, Jiangh Cheng, research scientist, and Jiazi Tian, data scientist, hold a meeting at Mass General Brigham. Estiri, Murphy, Tian and Cheng were authors on the algorithm that can diagnose long COVID by scanning medical records. All work has been done through the Center for AI and Biomedical Informatics of the Learning Healthcare Systems (CAIBILS). \" class=\"height_a width_full invisible width_full--mobile width_full--tablet-only\" src=\"https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440\" srcset=\"https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 1440w, https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 1280w, https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 1024w, https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 820w, https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 600w, https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 420w, https:\/\/bostonglobe-prod.cdn.arcpublishing.com\/resizer\/v2\/BEY274ILODLVHBLPVSLCQ5UXNE.JPG?auth=6ff35a7b5df10fcdf51feae6bf7fd46006927afbf6503be352ab7b1f36707efa&amp;width=1440 240w\" loading=\"lazy\"\/><figcaption class=\" img_caption | margin_horizontal_0--mobile margin_horizontal_0--tablet&#10;        \"><span class=\"caption | margin_right_half\">(from left) Shawn Murphy, chief research information officer, Hossein Estiri, head of AI Research, Jiangh Cheng, research scientist, and Jiazi Tian, data scientist, hold a meeting at Mass General Brigham. Estiri, Murphy, Tian and Cheng were authors on the algorithm that can diagnose long COVID by scanning medical records. All work has been done through the Center for AI and Biomedical Informatics of the Learning Healthcare Systems (CAIBILS). <\/span><span class=\"credit uppercase\">Danielle Parhizkaran\/Globe Staff<\/span><\/figcaption><\/figure>\n<\/div>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">To calculate their number, Estiri\u2019s team built a custom artificial intelligence tool to analyze data from the electronic health records of more than 295,000 patients served at four hospitals and 20 community health centers in Massachusetts. The AI program pulled out 85,000 people who had been diagnosed with COVID through June 2022, and then applied a pattern recognition algorithm to identify those that matched the criteria for long COVID in the 12 months that followed.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Some researchers questioned the paper\u2019s conclusions. Dr. Eric Topol, author of the 2019 book \u201cDeep Medicine: How Artificial Intelligence Can Make Healthcare Human Again,\u201d said the medical field is still divided over precisely what constitutes long COVID, and that complicates efforts to program an accurate AI algorithm.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">\u201cSince we have difficulties with defining long Covid, using AI on electronic health records may not be a way to make the diagnosis accurately,\u201d said Topol, who is executive vice president of Scripps Research in San Diego. \u201cI\u2019m uncertain about this report.\u201d<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Dr. Ziyad Al-Aly, chief of research and development at the VA St. Louis Health Care System, and an expert on long COVID, called the 22.8 percent figure unrealistically high and said the paper \u201cgrossly inflates\u201d its prevalence.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">\u201cTheir approach does not account for the fact that things happen without COVID (not everything that happens after COVID is attributable to COVID)\u2014 resulting in significant over-inflation of prevalence estimate,\u201d he wrote via email.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Estiri said the research team took  several measures to validate its AI algorithm, retroactively applying it to the charts of 800 people who had received a confirmed long COVID diagnosis from their doctor to see if it could predict the condition. The algorithm accurately diagnosed them more than three quarters of the time.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">The algorithm scanned the records for patients who had a COVID diagnosis prior to July 2022, then looked for a constellation of symptoms that could not be explained by other conditions and lasted longer than two months. To refine the program, they conferred with clinicians and assigned different weights to different symptoms and conditions based on how often they are associated with long COVID, which made them more likely to be identified as potential sufferers.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">Now that the initial paper has been published, the team is building a new algorithm that can be trained  to detect the presence of long COVID in the medical records of patients without a confirmed COVID-19 diagnosis so the condition can be confirmed by clinicians and they can get the care they need, Estiri said.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">But the most exciting part of the new research, Estiri said, is its potential to facilitate follow-up research and help refine and individualize treatment plans. In the months ahead, Estiri and his co-principal investigator Shawn Murphy, chief research information officer at Mass General Brigham, plan to ask a wide variety of questions by querying the medical records<b> <\/b>in their sample. Does vaccination make a patient more or less likely to develop the condition? How about treatment with Paxlovid? Do the symptoms patients develop differ based on those factors? What are the genomic characteristics of patients who are suffering from cardiovascular symptoms as opposed to those whose symptoms are associated with lung function or those who crash after exercising? Can they identify biomarkers in the bloodstream that could be used for diagnosis?<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">They have already prepared studies on vaccine efficacy, the effect of age as a risk factor, and whether the risk of long COVID increases with the fourth and fifth infection, Estiri said.<\/span><\/p>\n<p class=\"paragraph | gutter_20_0\"><span class=\"html-render\">\u201cWe were waiting for this paper to come out,\u201d he said. \u201cSo now we can actually go ahead with the follow-up studies. With this cohort we can do things that no other study has been able to do, and I\u2019m hoping it can really help people.\u201d<\/span><\/p>\n<hr class=\"tagline_hr | border_foreground border_half gutter_20_28--mobile&#10;               margin_none text_align_left width_100px\"\/>\n<p class=\"tagline | font_primary inline_block  margin_top_32\">Adam Piore can be reached at <a href=\"https:\/\/www.bostonglobe.com\/2024\/11\/16\/metro\/long-covid-prevalence-treatment\/mailto:adam.piore@globe.com\" class=\"\" target=\"_blank\" style=\"font-size:inherit;letter-spacing:.5px\" rel=\"noopener\">adam.piore@globe.com<\/a>.<\/p>\n<\/div>\n<p><script type=\"text\/javascript\">\nvar oneTrustActive = true;\nvar oneTrustConsentObj;\ntry {\n oneTrustConsentObj = JSON.parse(window.localStorage.getItem('consent_one_trust_bgmp') || '{}');\n} catch (err) {\n oneTrustConsentObj = {};\n}\n\/\/ Default to granted consent\nvar consent=\"grant\"\n\/\/ FB script decleration\n!function(f,b,e,v,n,t,s) {\n  if(f.fbq)return;n=f.fbq=function(){n.callMethod?n.callMethod.apply(n,arguments):n.queue.push(arguments)};\n  if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';\n  n.queue=[];t=b.createElement(e);t.async=!0;\n  t.src=v;s=b.getElementsByTagName(e)[0];\n  s.parentNode.insertBefore(t,s);\n}\n(window,document,'script', 'https:\/\/connect.facebook.net\/en_US\/fbevents.js');\nif (oneTrustActive && oneTrustConsentObj && oneTrustConsentObj.C0004 === false) {\n  consent=\"revoke\";\n}\n\/\/ We need to call consent before we run init and track\nfbq('consent', consent);\nfbq('set', 'autoConfig', 'false', '884869448226452');\nfbq('set', 'autoConfig', 'false', '493062270895851');\nfbq('init', '884869448226452');\nfbq('track', 'PageView');\n<\/script><br \/>\n<br \/><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.bostonglobe.com\/2024\/11\/16\/metro\/long-covid-prevalence-treatment\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Though the pandemic hit hardest in communities of color where residents had high rates of preexisting conditions and many held service industry jobs that placed them at high risk of &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=126983\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-126983","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=126983"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/126983\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=126983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=126983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=126983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}