{"id":127221,"date":"2024-11-18T09:49:53","date_gmt":"2024-11-18T02:49:53","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=127221"},"modified":"2024-11-18T09:49:53","modified_gmt":"2024-11-18T02:49:53","slug":"study-finds-potential-downside-to-vigorous-exercise-that-we-didnt-know-about-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=127221","title":{"rendered":"Study Finds Potential Downside to Vigorous Exercise That We Didn&#8217;t Know About : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Bad news for any extreme exercise junkies out there: excessive vigorous exercise could muffle your immune system. At least, that&#8217;s what a 2023 study analyzing over 4,700 post-exercise fluid molecules from firefighters suggests.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>This may be problematic for workers with consistently physically demanding jobs that require intense fitness training, such as emergency workers and athletes.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;People who are very fit might be more prone to viral respiratory infection immediately after vigorous exercise,&#8221; <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1007461\">said<\/a> Pacific Northwest National Laboratory (PNNL) biomedical scientist Ernesto Nakayasu. &#8220;Having less inflammatory activity to fight off an infection could be one cause.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While there is <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32139352\/\">strong evidence<\/a> to suggest that moderate physical activity among healthy individuals <a href=\"https:\/\/ashpublications.org\/bloodadvances\/article\/4\/8\/1801\/454550\/Impact-of-exercise-on-the-immune-system-and\">can favor the immune system<\/a> in the long run, what happens to the immune system directly following vigorous exercise is <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5911985\/\">controversial<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>There is little reliable evidence that supports the claim that intense exercise heightens the risk of opportunistic infections, although a few <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16558471\">previous<\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2266764\/\">studies<\/a> have <a href=\"https:\/\/www.doi.org\/10.1249\/MSS.0b013e318243253d\">noted<\/a> self-reported upper tract respiratory infections in athletes, compared to control groups, after strenuous activities. Whether these are correlations or causations is unknown.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>So Nakayasu and colleagues tested the blood plasma, urine, and saliva, from 11 firefighters before and after 45 minutes of intense exercise hauling up to 20 kilograms (44 pounds) of gear over hilly terrain.<\/p>\n<figure id=\"attachment_143822\" aria-describedby=\"caption-attachment-143822\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/CarryingGearUpHill642.jpg\" alt=\"People carrying gear up a hill\" width=\"642\" height=\"500\" class=\"size-full wp-image-143822\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/CarryingGearUpHill642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CarryingGearUpHill642-533x415.jpg 533w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CarryingGearUpHill642-600x467.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-143822\" class=\"wp-caption-text\">People who are very fit might be more prone to viral respiratory infection immediately after vigorous exercise. (<a href=\"https:\/\/www.pexels.com\/photo\/hikers-walking-uphill-8482180\/\">Kirill Lazarev\/Pexels<\/a>)<\/figcaption><\/figure>\n<p>&#8220;We wanted to take an in-depth look at what&#8217;s happening in the body and see if we&#8217;re able to detect danger from exhaustion in its earliest stages,&#8221; <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1007461\">explained<\/a> PNNL bioanalytical chemist Kristin Burnum-Johnson. &#8220;Perhaps we can reduce the risk of strenuous exercise for first responders, athletes, and members of the military.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>There&#8217;s no question exercise does wonders for our health, from boosting moods to <a href=\"https:\/\/www.sciencealert.com\/exercise-might-delay-the-spread-of-cancer-by-fuelling-the-immune-system\">strengthening our immune systems<\/a>. But as in previous studies, the new research detected possible signs of immune suppression within the worked-out firefighters.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Amidst the expected physical changes helping our bodies maintain the increase in fluids, energy, and oxygen that exercise demands, there was a decrease in molecules involved in inflammation. This was accompanied by increased <a href=\"https:\/\/en.wikipedia.org\/wiki\/Opiorphin\">opiorphin<\/a>, a dilator of peripheral blood vessels.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>What these changes ultimately mean for the short-term function of the immune system is unclear, but the researchers have a few ideas.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;[Opiorphin] may increase blood flow to muscles during the exercise regimen to improve the delivery of oxygen and nutrients,&#8221; the team <a href=\"https:\/\/doi.org\/10.1186\/s40779-023-00477-5\">writes in their paper<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We postulate that the decrease in inflammatory molecules we observed in the saliva after exercise might represent an adaptive mechanism to improve gas exchange in response to higher cellular oxygen demand.&#8221;<\/p>\n<figure id=\"attachment_143821\" aria-describedby=\"caption-attachment-143821\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/ManWorkingOut642.jpg\" alt=\"A man using battle ropes\" width=\"642\" height=\"500\" class=\"size-full wp-image-143821\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/ManWorkingOut642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/ManWorkingOut642-533x415.jpg 533w, https:\/\/www.sciencealert.com\/images\/2024\/11\/ManWorkingOut642-600x467.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-143821\" class=\"wp-caption-text\">There&#8217;s no question exercise does wonders for our health. (<a href=\"https:\/\/www.canva.com\/photos\/MADt-FxXAaE\/\">Ugur Karakoc\/Canva<\/a>)<\/figcaption><\/figure>\n<p>There was change in the participants&#8217; oral microbiome too. The scientists suspect this was due to the increase in antimicrobial peptides found in the firefighter&#8217;s mouths after their intense activity, possibly to compensate for the immune suppression, although this conclusion is <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5911985\/\">contested<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;However, this increase in antimicrobial peptides had no effect on inhibiting <em>E. coli<\/em> growth,&#8221; Nakayasu and colleagues <a href=\"https:\/\/doi.org\/10.1186\/s40779-023-00477-5\">elaborate<\/a>, &#8220;suggesting a limited capacity of antimicrobial peptides within the oral cavity to protect against host infections.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>That said, other scientists argue some of the changes observed may not be indications of immune suppression but of a &#8220;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5911985\/\">heightened state of immune surveillance and immune regulation<\/a>&#8220;.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While a within-subject comparison reduced the impact of their small sample size, firefighters experience unique exposures to pollutants during fires which may also change their immune reactions.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>What&#8217;s more, this study only considered healthy and active men, the researchers cautioned, so further research amongst a broader community is needed to confirm their findings.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>However, taken with previous studies, &#8220;there is evidence supporting a relationship between physical demands and a higher incidence of respiratory infections,&#8221; Nakayasu and team <a href=\"https:\/\/doi.org\/10.1186\/s40779-023-00477-5\">conclude<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>This research was published in <a href=\"https:\/\/doi.org\/10.1186\/s40779-023-00477-5\"><em>Military Medical Research<\/em><\/a>.<\/p>\n<p><em>An earlier version of this article was published in November 2023<\/em>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/study-finds-potential-downside-to-vigorous-exercise-that-we-didnt-know-about\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bad news for any extreme exercise junkies out there: excessive vigorous exercise could muffle your immune system. At least, that&#8217;s what a 2023 study analyzing over 4,700 post-exercise fluid molecules &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=127221\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8628],"tags":[],"class_list":["post-127221","post","type-post","status-publish","format-standard","hentry","category-science","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/127221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=127221"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/127221\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=127221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=127221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=127221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}