{"id":127596,"date":"2024-11-19T09:38:44","date_gmt":"2024-11-19T02:38:44","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=127596"},"modified":"2024-11-19T09:38:44","modified_gmt":"2024-11-19T02:38:44","slug":"repurposed-multiple-sclerosis-drug-may-improve-memory","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=127596","title":{"rendered":"Repurposed Multiple Sclerosis Drug May Improve Memory"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Fampridine, used for improving walking in multiple sclerosis, may also enhance working memory in individuals with schizophrenia or depression. A study found that the drug significantly improved working memory in participants with initially poor performance, but had no effect on those with strong baseline memory.<\/p>\n<p>Fampridine increases brain excitability, enabling faster stimulus processing, making it a potential treatment for conditions involving cognitive impairments. Researchers plan further studies to explore its efficacy in mental health disorders.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>Fampridine improves working memory only in individuals with poor baseline performance.<\/li>\n<li>The drug enhances brain excitability, facilitating faster processing of stimuli.<\/li>\n<li>Researchers are planning trials to test its effectiveness in schizophrenia and depression.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Basel<\/p>\n<p><strong>Fampridine is currently used to improve walking ability in multiple sclerosis. A new study shows that it could also help individuals with reduced working memory, as seen in mental health conditions like schizophrenia or depression.<\/strong><\/p>\n<p>Remembering a code for long enough to type it in; holding a conversation and reacting appropriately to what is being said: in everyday situations like these, we use our working memory.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106298\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience.jpg\" alt=\"This shows a brain.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/ms-drug-memory-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The researchers also observed that fampridine increased brain excitability in all participants, thus enabling faster processing of stimuli. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>It allows a memory to be actively retained for a few seconds. Certain conditions, such as schizophrenia or depression, as well as ADHD, impair working memory. Those affected lose track in conversations and struggle to organize their thoughts.<\/p>\n<p>Fampridine is a drug that could help in such cases, as researchers led by Professor Andreas Papassotiropoulos and Professor Dominique de Quervain at the University of Basel have shown.<\/p>\n<p>The team has reported their findings in the journal\u00a0<em>Molecular Psychiatry<\/em>.<\/p>\n<p><strong>Effective only if working memory is poor<\/strong><\/p>\n<p>In their study, the researchers tested the effectiveness of fampridine on working memory in 43 healthy adults. It was in those participants whose baseline working memory was at a low level that fampridine showed a more pronounced effect: after taking the active substance for three days, they scored better in the relevant tests than those who took the placebo. In contrast, in people who already had good baseline working memory, the drug showed no effect.<\/p>\n<p>The researchers also observed that fampridine increased brain excitability in all participants, thus enabling faster processing of stimuli. The study was randomized and double-blind.<\/p>\n<p><strong>Established drug, new application<\/strong><\/p>\n<p>\u201cFampridine doesn\u2019t improve working memory in everyone. But it could be a treatment option for those with reduced working memory,\u201d explains Andreas Papassotiropoulos.<\/p>\n<p>Dominique de Quervain adds: \u201cThat\u2019s why, together with researchers from the University Psychiatric Clinics Basel (UPK), we\u2019re planning studies to test the efficacy of fampridine in schizophrenia and depression.\u201d<\/p>\n<p>The drug is currently used to improve walking ability in multiple sclerosis (MS). Particularly in capsule form, which releases the active ingredient slowly in the body, fampridine has shown effects on cognitive performance in MS patients: for some, it alleviates the mental fatigue that can accompany MS.<\/p>\n<p>The researchers did not select the drug at random: this study followed comprehensive analyses of genome data in order to find starting points for repurposing established drugs.<\/p>\n<p>Fampridine acts on specific ion channels in nerve cells that, according to the researchers\u2019 analyses, also play a role in mental disorders such as schizophrenia.<\/p>\n<h2 class=\"wp-block-heading\">About this memory and neuropharmacology research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#65040b0200090c0e044b0f04060a071625100b0c0704164b060d\" target=\"_blank\" rel=\"noreferrer noopener\">Angelika Jacobs<\/a><br \/><strong>Source:<\/strong><a href=\"https:\/\/unibas.ch\" target=\"_blank\" rel=\"noreferrer noopener\"><strong> <\/strong>University of Basel<\/a><br \/><strong>Contact: <\/strong>Angelika Jacobs \u2013 University of Basel<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/dx.doi.org\/10.1038\/s41380-024-02820-1\" target=\"_blank\" rel=\"noreferrer noopener\">The effect of fampridine on working memory: A randomized controlled trial based on a genome-guided repurposing approach<\/a>\u201d by Andreas Papassotiropoulos et al. <em>Molecular Psychiatry<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>The effect of fampridine on working memory: A randomized controlled trial based on a genome-guided repurposing approach<\/strong><\/p>\n<p>Working memory (WM), a key component of cognitive functions, is often impaired in psychiatric disorders such as schizophrenia. Through a genome-guided drug repurposing approach, we identified fampridine, a potassium channel blocker used to improve walking in multiple sclerosis, as a candidate for modulating WM.<\/p>\n<p>In a subsequent double-blind, randomized, placebo-controlled, crossover trial in 43 healthy young adults (ClinicalTrials.gov, NCT04652557), we assessed fampridine\u2019s impact on WM (3-back d-prime, primary outcome) after 3.5 days of repeated administration (10\u2009mg twice daily). Independently of baseline cognitive performance, no significant main effect was observed (Wilcoxon\u00a0<em>P<\/em>\u2009=\u20090.87, r\u2009=\u20090.026).<\/p>\n<p>However, lower baseline performance was associated with higher working memory performance after repeated intake of fampridine compared to placebo (r<sub>s<\/sub>\u2009=\u2009\u22120.37,\u00a0<em>P<\/em>\u2009=\u20090.014,\u00a0<em>n<\/em>\u2009=\u200943).<\/p>\n<p>Additionally, repeated intake of fampridine lowered resting motor threshold (F(1,37)\u2009=\u20095.31,\u00a0<em>P<\/em>\u2009=\u20090.027, R<sup>2<\/sup>\u03b2\u2009=\u20090.01), the non-behavioral secondary outcome, indicating increased cortical excitability linked to cognitive function.<\/p>\n<p>Fampridine\u2019s capacity to enhance WM in low-performing individuals and to increase brain excitability points to its potential value for treating WM deficits.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/fampridine-working-memory-28071\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Fampridine, used for improving walking in multiple sclerosis, may also enhance working memory in individuals with schizophrenia or depression. A study found that the drug significantly improved working memory &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=127596\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-127596","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/127596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=127596"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/127596\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=127596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=127596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=127596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}