{"id":128667,"date":"2024-11-22T04:55:05","date_gmt":"2024-11-21T21:55:05","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=128667"},"modified":"2024-11-22T04:55:05","modified_gmt":"2024-11-21T21:55:05","slug":"immune-system-gene-linked-to-hyperactivity-adhd-and-autism","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=128667","title":{"rendered":"Immune System Gene Linked to Hyperactivity, ADHD and Autism"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers have uncovered a link between the immune gene regulator STAT1 and hyperactive behaviors in mice, offering new insights into neurodevelopmental disorders like autism and ADHD. STAT1, vital for infection response, also influences brain cell activity, particularly dopamine neurons involved in motivation and learning.<\/p>\n<p>In mice with prolonged STAT1 signaling, hyperactivity and reduced neural activity in key brain regions were observed. The study opens the door to targeting STAT1 for potential therapies to address neurobehavioral disorders.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Prolonged STAT1 signaling in dopamine neurons led to hyperactivity and fewer neurons in regions tied to learning and reward.<\/li>\n<li>The study highlights communication between the immune system and brain development.<\/li>\n<li>Future research will explore therapies targeting STAT1 to treat neurodevelopmental disorders.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Duke University<\/p>\n<p><strong>Building on research that has linked immune responses with certain neurobehavioral conditions, researchers at Duke Health have identified how a key infection-fighting function is involved in triggering hyperactive behaviors in mice.<\/strong><\/p>\n<p>The finding, appearing this month in the journal<em>\u00a0Brain, Behavior, and Immunity,<\/em> adds insight to an on-off switch for genes called STAT1. This gene regulator plays a pivotal role in the immune system\u2019s response to infections and has also been implicated in various neurodevelopmental disorders such as autism and ADHD.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106411\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience.jpg\" alt=\"This shows a brain.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/immune-gene-adhd-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Prolonged STAT1 signaling in neurons, beginning during embryonic development, led to hyperactive behavior and fewer neurons and reduced neural activity in an area of the brain involved in learning, memory, reward and motivation. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cA lot of these pathways that have been discovered in the immune system also play important roles in the brain,\u201d said senior author\u00a0Anthony Filiano, Ph.D., assistant professor in the departments of\u00a0Neurosurgery\u00a0and\u00a0Pathology\u00a0at Duke University School of Medicine and a faculty member in the Marcus Center for Cellular Cures.<\/p>\n<p>\u201cThere is a very robust communication between the two systems. This is intriguing because the immune system is very targetable from a therapy perspective.\u201d<\/p>\n<p>Filiano and colleagues at Duke worked with a team at Columbia University that bred mice with a STAT1 mutation. Using these mice, they were able to over-activate the immune pathway in different cell types of the brain, including dopamine neurons, which help modulate reward, motivation, and motor control.<\/p>\n<p>\u201cProlonged STAT1 signaling in neurons, beginning during embryonic development, led to hyperactive behavior and fewer neurons and reduced neural activity in an area of the brain involved in learning, memory, reward and motivation,\u201d Filiano said.<\/p>\n<p>\u201cThese results suggest that STAT1 signaling in dopamine neurons has a role in regulating behavior and disruption of this signaling may contribute to neurodevelopmental disorders.\u201d<\/p>\n<p>Filiano said further studies will explore whether it\u2019s possible to target the STAT1 pathway with therapies: \u201cWe need to understand its function and target it more specifically before we move forward,\u201d he said.<\/p>\n<p>In addition to Filiano, study authors include Danielle N. Clark, Shelby Brown, Li Xu, Rae-Ling Lee, Joey V. Ragusa, Zhenghao Xu, and Joshua D. Milner.<\/p>\n<p><strong>Funding: <\/strong>The study received funding support from the National Institutes of Health (NS123084), the Marcus Foundation, and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intramural research program.<\/p>\n<h2 class=\"wp-block-heading\">About this genetics, ADHD, and Autism research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#4b382a392a23652a3d2e39320b2f3e202e652e2f3e\" target=\"_blank\" rel=\"noreferrer noopener\">Sarah Avery<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/duke.edu\" target=\"_blank\" rel=\"noreferrer noopener\">Duke University<\/a><br \/><strong>Contact: <\/strong>Sarah Avery \u2013 Duke University<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research:<\/strong> Open access.<br \/>\u201c<a href=\"https:\/\/doi.org\/10.1016\/j.bbi.2024.11.018\" target=\"_blank\" rel=\"noreferrer noopener\">Prolonged STAT1 signaling in neurons causes hyperactive behavior<\/a>\u201d by Anthony Filiano et al. <em>Brain, Behavior, and Immunity<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Prolonged STAT1 signaling in neurons causes hyperactive behavior<\/strong><\/p>\n<p>The interferon (IFN)-induced STAT1 signaling pathway is a canonical immune pathway that has also been implicated in regulating neuronal activity.<\/p>\n<p>The pathway is enriched in brains of individuals with autism spectrum disorder (ASD) and schizophrenia (SZ). Over-activation of the STAT1 pathway causes pathological transcriptional responses, however it is unclear how these responses might translate into behavioral phenotypes.<\/p>\n<p>We hypothesized that prolonged STAT1 signaling in neurons would be sufficient to cause behavioral deficits associated with neurodevelopmental disorders.<\/p>\n<p>In this study, we developed a novel mouse model with the clinical STAT1 gain-of-function mutation, T385M, in neurons. These mice were hyperactive and displayed neural hypoactivity with less neuron counts in the caudate putamen.<\/p>\n<p>Driving the STAT1 gain-of-function mutation exclusively in dopaminergic neurons, which project to the caudate putamen of the dorsal striatum, mimicked some hyperactive behaviors without a reduction of neurons.<\/p>\n<p>Moreover, we demonstrated that this phenotype is neuron specific, as mice with prolonged STAT1 signaling in all excitatory or inhibitory neurons or in microglia were not hyperactive.<\/p>\n<p>Overall, these findings suggest that STAT1 signaling in neurons is a crucial player in regulating striatal neuron activity and aspects of motor behavior.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/stat1-hyperactivity-asd-adhd-28104\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers have uncovered a link between the immune gene regulator STAT1 and hyperactive behaviors in mice, offering new insights into neurodevelopmental disorders like autism and ADHD. 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