{"id":128828,"date":"2024-11-22T15:04:46","date_gmt":"2024-11-22T08:04:46","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=128828"},"modified":"2024-11-22T15:04:46","modified_gmt":"2024-11-22T08:04:46","slug":"drugs-like-ozempic-may-have-a-shrinking-effect-on-the-heart-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=128828","title":{"rendered":"Drugs Like Ozempic May Have a Shrinking Effect on The Heart : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Popular weight loss drugs like Ozempic and Wegovy are showing incredible short-term benefits \u2013 from <a href=\"https:\/\/www.sciencealert.com\/are-weight-loss-drugs-like-ozempic-for-you-consider-these-risks-and-benefits\">boosted metabolic health<\/a> to <a href=\"https:\/\/www.sciencealert.com\/ozempic-gives-strong-relief-to-severe-knee-pain-clinical-trial-suggests\">pain relief<\/a> to <a href=\"https:\/\/www.sciencealert.com\/ozempic-like-drugs-could-help-manage-addiction-to-drugs-and-alcohol\">addiction<\/a> and <a href=\"https:\/\/www.sciencealert.com\/type-2-diabetes-drug-linked-to-35-lower-dementia-risk-in-patients\">cognitive health<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>These are really promising initial signs, but it&#8217;s important to remember the long-term side effects are still coming to light.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Recently, some experts have <a href=\"https:\/\/www.sciencealert.com\/experts-are-concerned-drugs-like-ozempic-may-cause-muscle-loss\">raised<\/a> <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.124.067676\">concerns<\/a> that novel weight loss drugs \u2013 known as glucagon-like peptide-1 (GLP-1) receptor agonists \u2013 could be causing significant skeletal muscle loss as well as fat loss. But there&#8217;s not enough data to say for sure.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Now, researchers at the University of Alberta in Canada have added to the discussion by bringing up a subset of muscles that only exist in the heart.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Cardiac muscles are what keep our hearts pumping blood around our bodies, and yet little research has investigated how these tissues deal with GLP-1 agonists.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>For 21 days, researchers at Alberta administered semaglutide \u2013 the active ingredient in Ozempic \u2013 to both lean and obese mice without  <a href=\"https:\/\/www.sciencealert.com\/diabetes\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73018\" data-postid=\"144382\" rel=\"nofollow noopener\" target=\"_self\">diabetes<\/a> or cardiac dysfunction.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The obese mice lost about 30 percent of their body weight and 65 percent of their fat mass compared to untreated mice.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Among lean mice that were treated with semaglutide, researchers noted a roughly 8 percent reduction in skeletal muscle over the course of three weeks.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While there were no observed changes to heart function or the thickness of heart walls, both groups of mice treated with semaglutide showed decreases in overall heart mass and the individual size of their heart muscle cells.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Together,&#8221; the authors <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2452302X24002869?via%3Dihub\">conclude<\/a>, &#8220;these data indicate that the reduction in cardiac size induced by semaglutide occurs independent of weight loss.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>To explore further, the team of researchers, led by clinical scientist Matthew Martens, turned to human cells. In the lab, when human cardiac muscle cells were treated with semaglutide, they showed significant reductions in size.<\/p>\n<figure id=\"attachment_144386\" aria-describedby=\"caption-attachment-144386\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize-642x377.png\" alt=\"Cardiomyocytes Semaglutide\" width=\"642\" height=\"377\" class=\"size-medium wp-image-144386\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize-642x377.png 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize-706x415.png 706w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize-768x451.png 768w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize-1536x902.png 1536w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize-600x352.png 600w, https:\/\/www.sciencealert.com\/images\/2024\/11\/CardiomyociteSize.png 2002w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-144386\" class=\"wp-caption-text\">The cardiomyocyte area of mice without semaglutide treatment (left) and with semaglutide treatment (right). (Martens et al., <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2452302X24002869?via%3Dihub\"><em>The Lancet<\/em><\/a>, 2024)<\/figcaption><\/figure>\n<p>Given these results, the authors admit it is tempting to speculate that semaglutide is responsible for cardiac shrinkage and atrophy. &#8220;However,&#8221; they <a href=\"https:\/\/doi.org\/10.1016\/j.jacbts.2024.07.006\">note<\/a>, &#8220;we do not observe any changes in recognized markers of atrophy.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The means they cannot be certain semaglutide is causing the atrophy of cardiac muscles, or even if this loss of muscle is a bad thing. In some cases, it could possibly confer benefits.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Nevertheless, the findings among mice and human cells <a href=\"https:\/\/doi.org\/10.1016\/j.jacbts.2024.07.006\">suggest<\/a> that semaglutide &#8220;has the potential to be detrimental in the long term&#8221; to heart muscles.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>If the findings translate to living humans, then it means people with existing cardiovascular disease or muscle atrophy could be placing their hearts at added risk if they are prescribed semaglutide or similar drugs.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>It&#8217;s unknown whether diet or exercise can offset these potential heart muscle losses, but that is something future research should investigate, as this seems to be the case with skeletal muscle loss.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We suggest that cardiac structure and function be carefully evaluated in previous and ongoing clinical studies,&#8221; Martens and his colleagues at Alberta <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2452302X24002869?via%3Dihub\">conclude<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The call to action is supported by another recent paper, published in a journal run by the American Heart Association, whose authors <a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCULATIONAHA.124.067676\">argue<\/a> the effects of GLP-1 agonists on muscle health should be studied in a &#8220;more objective and comprehensive&#8221; way, especially given &#8220;the substantial numbers of patients who will likely be taking these medications well into the future.&#8221;<\/p>\n<p>The study was published in <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2452302X24002869?via%3Dihub\"><i>The Lancet<\/i><\/a>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/drugs-like-ozempic-may-have-a-shrinking-effect-on-the-heart\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Popular weight loss drugs like Ozempic and Wegovy are showing incredible short-term benefits \u2013 from boosted metabolic health to pain relief to addiction and cognitive health. These are really promising &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=128828\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-128828","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/128828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=128828"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/128828\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=128828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=128828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=128828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}