{"id":128876,"date":"2024-11-22T18:07:07","date_gmt":"2024-11-22T11:07:07","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=128876"},"modified":"2024-11-22T18:07:07","modified_gmt":"2024-11-22T11:07:07","slug":"type-2-diabetes-linked-to-accelerated-brain-shrinkage-study-reveals-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=128876","title":{"rendered":"Type 2 Diabetes Linked to Accelerated Brain Shrinkage, Study Reveals : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>A gradual loss of brain tissue is a natural part of aging, but one of the longest-running brain scan studies has now revealed some people&#8217;s neural connections deteriorate faster than others once they hit middle age.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>According to a decades-long trial that began in 1995, those who show higher losses in white matter \u2013 the tissue that contains nerve fibers \u2013 have an 86 percent greater risk of developing mild cognitive impairment (MCI).<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Compared to those without a metabolic disease, those with type 2  <a href=\"https:\/\/www.sciencealert.com\/diabetes\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73018\" data-postid=\"143558\" rel=\"nofollow noopener\" target=\"_self\">diabetes<\/a> lost significantly more white matter over time, and this group ultimately faced a 41 percent higher risk of developing MCI.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>What&#8217;s more, people with biomarkers of dementia in their cerebrospinal fluid (CFS) had a nearly 50 percent higher risk of cognitive impairment.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>If an individual had <i style=\"letter-spacing: -0.025em;\">both<\/i> diabetes <i style=\"letter-spacing: -0.025em;\">and<\/i> biomarkers of amyloid plaques (which are associated with  <a href=\"https:\/\/www.sciencealert.com\/go\/IaO\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73015\" data-postid=\"143558\" rel=\"nofollow noopener\" target=\"_self\">Alzheimer&#8217;s<\/a> disease), that risk jumps to 55 percent.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p><a href=\"https:\/\/www.sciencealert.com\/a-completely-new-cause-of-alzheimers-uncovered-in-our-brains-white-matter\">Previous studies<\/a> have also shown that significant losses in white matter are tied to cases of dementia, and that <a href=\"https:\/\/www.sciencealert.com\/study-suggests-diabetes-and-high-blood-pressure-might-also-be-affecting-your-mind\">metabolic disorders<\/a> can elevate a person&#8217;s risk of cognitive decline.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>But this is the first study to show a synergistic relationship between diabetes and amyloid plaques when it comes to their impact on white matter.<\/p>\n<figure id=\"attachment_144063\" aria-describedby=\"caption-attachment-144063\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/MyelinSheathsNerveFibers642.jpg\" alt=\"Long tubes with pink insides\" width=\"642\" height=\"500\" class=\"size-full wp-image-144063\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/MyelinSheathsNerveFibers642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/MyelinSheathsNerveFibers642-533x415.jpg 533w, https:\/\/www.sciencealert.com\/images\/2024\/11\/MyelinSheathsNerveFibers642-600x467.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-144063\" class=\"wp-caption-text\">Colored scanning electron micrograph of myelinated nerve fibers (axons). Axons are the main component of white matter in the brain. (<a href=\"https:\/\/www.canva.com\/photos\/MADmTLSIUvk\/\">Science Photo Library\/Canva<\/a>)<\/figcaption><\/figure>\n<p>&#8220;These findings highlight that white matter volume changes are closely associated with cognitive function in aging, suggesting that white matter degeneration may play a crucial role in cognitive decline,&#8221; <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2825474\">write<\/a> the authors of the study, led by neuroscientists at Johns Hopkins University in the United States.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;As insulin resistance plays a critical role in the formation of amyloid plaques, diabetes may promote Alzheimer&#8217;s disease pathology, resulting in an earlier progression from normal cognition to MCI.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The long-term study was conducted among a group of 185 participants, who were mostly well-educated and White, with a family history of dementia.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>It&#8217;s not clear how well the findings will translate to more diverse populations, but most long-term  <a href=\"https:\/\/www.sciencealert.com\/magnetic-resonance-imaging\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73063\" data-postid=\"143558\" rel=\"nofollow noopener\" target=\"_self\">MRI<\/a> studies to date have been limited to less than a decade, and many only take two time points into account.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>This newest study is impressively long, albeit small, tracking the brain shapes and sizes of participants at multiple points in their lives.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>For up to 27 years, scientists regularly scanned the brains of participants, who started the trial with unimpaired cognition between the ages of 20 and 76.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>At the end of the trial, 60 participants had progressed to mild cognitive impairment (MCI), and 8 of those participants went on to develop dementia.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Each person had their brain scanned about five times, and based on those images, it seems that it&#8217;s normal as you age to gradually lose cortical <a href=\"https:\/\/en.wikipedia.org\/wiki\/Grey_matter\">gray matter<\/a>, which contains neuron bodies, as well as <a href=\"https:\/\/en.wikipedia.org\/wiki\/White_matter\">white matter<\/a>, which conducts messages between neurons.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>What is unusual, however, is a more rapid deterioration in white matter, starting in middle age. Participants who experienced the greatest declines in white matter volumes, year to year, were far more likely to develop symptoms of MCI.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While only eight participants had a diagnosis of type 2 diabetes, the authors say their results suggest &#8220;that controlling diabetes may help reduce the risk of Alzheimer&#8217;s dementia later in life as a modifiable risk factor.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p><a href=\"https:\/\/www.sciencealert.com\/type-2-diabetes-drug-linked-to-35-lower-dementia-risk-in-patients\">Recent research<\/a>, for instance, has shown that some drugs that treat type 2 diabetes are linked to a 35 percent lower risk of dementia in patients.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Physician-scientist Shohei Fujita, who was not involved in the study, reviewed the findings in an <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2825477\">invited commentary<\/a> for <i>JAMA&#8217;s Neurology<\/i>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Fujita applauds the &#8220;extended time frame&#8221; of the trial, and he hopes the findings &#8220;enable researchers and clinicians to develop targeted interventions for those most susceptible to progressive brain changes.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Notably, 63 percent of the cohort were women, and Fujita points out that &#8220;gender and race are also crucial variables that must be considered&#8221; in future longitudinal research.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>After all, cognitive decline and dementia do not impact everyone in the same way. The way each individual brain shrinks with age is bound to be highly variable.<\/p>\n<p>The study was published in <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2825474\"><i>JAMA Network<\/i><\/a>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/type-2-diabetes-linked-to-accelerated-brain-shrinkage-study-reveals\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A gradual loss of brain tissue is a natural part of aging, but one of the longest-running brain scan studies has now revealed some people&#8217;s neural connections deteriorate faster than &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=128876\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-128876","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/128876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=128876"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/128876\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=128876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=128876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=128876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}