{"id":129098,"date":"2024-11-23T08:21:57","date_gmt":"2024-11-23T01:21:57","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=129098"},"modified":"2024-11-23T08:21:57","modified_gmt":"2024-11-23T01:21:57","slug":"chinese-scientists-report-promising-results-from-novel-alzheimers-surgery","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=129098","title":{"rendered":"Chinese Scientists Report &#8216;Promising Results&#8217; From Novel Alzheimer&#8217;s Surgery"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div style=\"position:relative;overflow:visible;font-size:1.2em;line-height:1.58\">\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Chinese researchers have reported initial results from an experimental surgical procedure they say aims to address Alzheimer&#8217;s disease through manipulating the brain&#8217;s waste clearance systems.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">The findings, published in <a href=\"https:\/\/gpsych.bmj.com\/content\/37\/3\/e101641\" target=\"_blank\" rel=\"nofollow external noopener\" class=\"sc-adb616fe-0 bJsyml\">General Psychiatry<\/a>, detail outcomes from what the team describes as a &#8220;cervical shunting&#8221; operation performed on a patient with Alzheimer who was able to achieve what the researchers describe as \u201cpromising\u201d results.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Alzheimer&#8217;s disease progressively damages brain cells, primarily affecting memory and cognitive functions. The condition occurs when proteins called beta-amyloid and tau accumulate abnormally in the brain, forming plaques and tangles that disrupt normal brain function. Like a city&#8217;s waste management system, the brain has its own cleanup mechanism<span class=\"s1\">\u2014<\/span>the glymphatic system<span class=\"s1\">\u2014<\/span>which removes these harmful proteins during sleep.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">\u201cWe speculated that decompression of the lymphatic trunk and cervical lymphatic<span class=\"s1\">\u2014<\/span>venous anastomosis (LVA) could facilitate the flow of cerebrospinal fluid in the cranial glymphatic system, potentially accelerating the clearance of harmful beta-amyloid and tau proteins,\u201d the researchers hypothesized.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">The study, conducted through a collaboration between Shanghai Mental Health Center, Shanghai Ninth People&#8217;s Hospital, and Shanghai Jiao Tong University, involved a patient who met the stringent biological diagnostic criteria set by the National Institute on Aging-Alzheimer&#8217;s Association. These criteria require evidence of both memory decline and biological markers of the disease, confirmed through brain scans showing protein deposits.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">The surgical team claims the procedure connects lymphatic vessels in the neck to veins, theoretically creating a new pathway to help flush out toxic proteins from the brain. According to their report, the patient showed cognitive improvements five weeks after surgery, measured through standard tests:<\/p>\n<ul>\n<li class=\"font-meta-serif-pro font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">The Mini-Mental Status Examination, which evaluates cognitive function, rose from 5 to 7 points<\/li>\n<li class=\"font-meta-serif-pro font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">The Clinical Dementia Rating-sum of boxes, measuring dementia severity, improved from 10 to 8<\/li>\n<li class=\"font-meta-serif-pro font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">The Geriatric Depression Scale, assessing depression in older adults, dropped from 9 to 0<\/li>\n<\/ul>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">\u201cMy mother&#8217;s memory is stabilizing and improving, and she is able to complete household chores every day,&#8221; said the patient\u2019s daughter four months after surgery.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Brain scans performed before and after the procedure reportedly showed changes in protein accumulation and metabolism, though the significance and durability of these changes remains to be determined. The patient&#8217;s daughter reported noticing memory improvements, according to the researchers.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Is this a <a href=\"https:\/\/x.com\/ChenKojira\/status\/1859658593588613336\" target=\"_blank\" rel=\"nofollow external noopener\" class=\"sc-adb616fe-0 bJsyml\">cure for Alzheimer<\/a>, as some have claimed? Not yet and maybe never. The researchers certainly haven\u2019t made such a claim and the research is still ongoing. Also, it\u2019s important to replicate such results on a broader population in order to claim a cure has been found<span class=\"s1\">\u2014<\/span>and that is still far from happening.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\"><span class=\"s1\">&#8220;Once the cortex is damaged, it does not regenerate, so while the hypothesis of improving lymphatic drainage is interesting, it is not enough to reverse irreversible damage,&#8221; <\/span><span class=\"s1\">Alberto Mart\u00ednez, an occupational doctor at Insalud in Ecuador, told <i>Decrypt<\/i>. &#8220;<\/span><span class=\"s1\">Although the hypothesis is intriguing, it cannot be stated with certainty that unclogging the lymphatic ducts can improve Alzheimer&#8217;s until more rigorous data and analyses are presented,\u201d he said.<\/span><\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\"><i>Decrypt <\/i>contacted Dr. Li and Dr. Ren alongside other neurologists to gather more insights to try and get further comment.<\/p>\n<h2 class=\"sc-b2a202e4-2 bmropA gg-dark:text-white scene:font-itc-avant-garde-gothic-pro scene:font-light\" style=\"margin-top:2em;text-align:left;padding-bottom:16px;margin-bottom:16px;border-bottom:1px solid #dfe2e4\" color=\"#333\">Hold your horses\u2026 but don\u2019t stop them<\/h2>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">While this surgical approach represents a novel direction in Alzheimer&#8217;s treatment research, it comes during what experts describe as a <a href=\"https:\/\/news.harvard.edu\/gazette\/story\/2023\/06\/start-of-new-era-for-alzheimers-treatment\/\" target=\"_blank\" class=\"sc-adb616fe-0 bJsyml\" rel=\"noopener\">new era<\/a> in the field. Currently, <a href=\"https:\/\/www.brightfocus.org\/alzheimers\/article\/whats-next-alzheimers-disease-treatments-2024-forecast\" target=\"_blank\" rel=\"nofollow external noopener\" class=\"sc-adb616fe-0 bJsyml\">171 ongoing studies<\/a> and 134 drugs are being tested in clinical trials, with over 77% of new treatments targeting disease-modifying approaches.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Recent developments have shown promise in slowing cognitive decline. The drug donanemab, recently approved and marketed as Kisunla, <a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-kisunlatm-donanemab-azbt-approved-fda-treatment-early\" target=\"_blank\" rel=\"nofollow external noopener\" class=\"sc-adb616fe-0 bJsyml\">demonstrated<\/a> a 35% slowing of cognitive decline in clinical trials. For patients who received the drug early in their disease progression, this figure climbed to 60%.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Other emerging treatments include ALZ-801, potentially the first the first disease-modifying oral medication for Alzheimer&#8217;s, and <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2212948\" target=\"_blank\" rel=\"nofollow external noopener\" class=\"sc-adb616fe-0 bJsyml\">Lecanemab <\/a>, which has shown encouraging early results in clearing amyloid proteins from the brain.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">Additionally, researchers are exploring alternative approaches like semaglutide, a diabetes medication that showed potential benefits for brain health, and even lifestyle interventions through the <a href=\"https:\/\/www.alz.org\/us-pointer\/home.asp\" target=\"_blank\" rel=\"nofollow external noopener\" class=\"sc-adb616fe-0 bJsyml\">U.S. POINTER Study<\/a>, which examines the impact of exercise and diet on cognition in at-risk individuals.<\/p>\n<p class=\"font-meta-serif-pro scene:font-noto-sans scene:text-base scene:md:text-lg font-normal text-lg md:text-xl md:leading-9 tracking-px text-body gg-dark:text-neutral-100\">But until there is a proven cure, the best thing to do is stay healthy to prevent it and don\u2019t overhype the small victories shared by researchers.<\/p>\n<div class=\"my-4 border-b border-decryptGridline\">\n<div class=\"text-start p-8 md:py-12 md:px-12 max-w-prose relative\"><span class=\"border-t-4 border-l-4 w-4 h-4 md:border-t-[6px] md:border-l-[6px] md:w-6 md:h-6 border-decryptPurple dark:border-decryptNeon gg-dark:border-cc-pink-2 absolute top-4 left-4 md:top-6 md:left-6\"\/><span class=\"border-t-4 border-l-4 w-4 h-4 md:border-t-[6px] md:border-l-[6px] md:w-6 md:h-6 border-decryptPurple dark:border-decryptNeon gg-dark:border-cc-pink-2 absolute rotate-180 bottom-4 right-4 md:bottom-6 md:right-6\"\/><\/p>\n<h3 class=\"font-akzidenz-grotesk font-bold text-xl md:text-3xl md:text-center gg-dark:text-white\">Generally Intelligent<!-- --> Newsletter<\/h3>\n<p>A weekly AI journey narrated by Gen, a generative AI model.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/decrypt.co\/293229\/chinese-scientists-novel-alzheimers-surgery\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chinese researchers have reported initial results from an experimental surgical procedure they say aims to address Alzheimer&#8217;s disease through manipulating the brain&#8217;s waste clearance systems. The findings, published in General &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=129098\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-129098","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/129098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=129098"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/129098\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=129098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=129098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=129098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}