{"id":129163,"date":"2024-11-23T12:25:56","date_gmt":"2024-11-23T05:25:56","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=129163"},"modified":"2024-11-23T12:25:56","modified_gmt":"2024-11-23T05:25:56","slug":"lab-grown-human-brains-could-help-cure-worlds-top-killer-disease","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=129163","title":{"rendered":"Lab-grown human brains could help cure world&#8217;s top killer disease"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div itemprop=\"articleBody\">\n<p class=\"mol-para-with-font\">Scientists\u00a0have grown tiny human brains in space to research new treatments for <a style=\"font-weight: bold;\" target=\"_self\" href=\"https:\/\/www.dailymail.co.uk\/sciencetech\/alzheimers-disease\/index.html\" id=\"mol-b505bb00-a8ea-11ef-aa0b-e31e0562061f\" class=\"\" rel=\"noopener\">Alzheimer&#8217;s<\/a>, Parkinson&#8217;s and spinal injuries.<\/p>\n<p class=\"mol-para-with-font\">The low gravity environment on the <a style=\"font-weight: bold;\" target=\"_self\" href=\"https:\/\/www.dailymail.co.uk\/news\/iss\/index.html\" id=\"mol-cd8152f0-a905-11ef-a2d8-a3b624cdc14e\" rel=\"noopener\">International Space Station<\/a> (ISS) enabled researchers to grow brain organoids in just 72 hours. This process can take months on Earth.\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">The organoids, which are artificially-grown masses of cells that mimic the structure and function of a human organ, allowed researchers to test a new method for curing <a style=\"font-weight: bold;\" target=\"_self\" class=\"\" href=\"https:\/\/www.dailymail.co.uk\/sciencetech\/article-13423135\/how-trauma-causes-alzheimers.html\" rel=\"noopener\">currently untreatable neurological diseases<\/a>.\u00a0<\/p>\n<p class=\"mol-para-with-font\"><span style=\"font-size: 16px;\">The promising new treatment, developed by biotechnology company Axonis Therapeutics, uses\u00a0<span style=\"font-size: 16px;\">a reprogrammed virus to deliver beneficial gene therapy to central nervous system cells (CNS).\u00a0<\/span><\/span><\/p>\n<p class=\"mol-para-with-font\"><span style=\"font-size: 16px;\"><span style=\"font-size: 16px;\">Such modified viruses are called viral vectors, and they could be particularly useful for treating Alzheimer&#8217;s, Parkinson&#8217;s and spinal cord injuries.\u00a0<\/span><\/span><\/p>\n<p class=\"mol-para-with-font\">Nearly 600,000 Americans are diagnosed with either Alzheimer&#8217;s or Parkinson&#8217;s each year, and roughly 18,000 new spinal cord injuries occur in the US annually.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Testing revealed that the company&#8217;s treatment worked in mice. But gene therapies that are effective in rodent models often fail in humans.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Axionis Therapeutics needed to perform tests using an accurate model of the human central nervous system, which is what prompted them to try and grow human brain organoids in space.\u00a0<\/p>\n<div class=\"artSplitter mol-img-group\" style=\"\">\n<div class=\"mol-img\">\n<div class=\"image-wrap\"> <img decoding=\"async\" id=\"i-f87a2b6b06b7f704\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2024\/11\/22\/18\/92378681-14114651-Scientists_on_the_International_Space_Station_ISS_have_grown_bra-a-18_1732299632287.jpg\" height=\"477\" width=\"634\" alt=\"Scientists on the International Space Station (ISS) have grown brain-like organoids in space to research new treatments for Alzheimer's, Parkinson's and spinal injuries\" class=\"blkBorder img-share\" style=\"max-width:100%\" loading=\"lazy\" \/> <\/div>\n<p> <noscript> <img loading=\"lazy\" decoding=\"async\" id=\"i-f87a2b6b06b7f704\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2024\/11\/22\/18\/92378681-14114651-Scientists_on_the_International_Space_Station_ISS_have_grown_bra-a-18_1732299632287.jpg\" height=\"477\" width=\"634\" alt=\"Scientists on the International Space Station (ISS) have grown brain-like organoids in space to research new treatments for Alzheimer's, Parkinson's and spinal injuries\" class=\"blkBorder img-share\" \/> <\/noscript> <\/div>\n<p class=\"imageCaption\">Scientists on the International Space Station (ISS) have grown brain-like organoids in space to research new treatments for Alzheimer&#8217;s, Parkinson&#8217;s and spinal injuries<\/p>\n<\/div>\n<p class=\"mol-para-with-font\">Scientists can grow CNS cells on Earth, but gravity forces them to arrange themselves into two-dimensional single layers,\u00a0<span style=\"font-size: 16px;\">which makes it difficult to culture the three-dimensional structure and complexity of brain cell functional groups.<\/span><\/p>\n<p class=\"mol-para-with-font\">These space-grown organoids quickly provided a highly accurate model of the human brain, allowing the ISS researchers to truly test the effectiveness of the new viral vector treatment.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;Doing research in space is not something you&#8217;d ever think about normally,&#8217; said Shane Hegarty, co-founder and chief scientific officer of Axonis Therapeutics.<\/p>\n<p class=\"mol-para-with-font\">&#8216;But the opportunity to leverage microgravity conditions can unlock a lot of untouched potential by pushing the boundaries of science in a unique environment,&#8217; he added in a <a style=\"font-weight: bold;\" class=\"\" rel=\"noreferrer noopener\" target=\"_blank\" href=\"https:\/\/issnationallab.org\/upward\/73-axonis-theraputics-brain-organoids\/\">statement<\/a>.\u00a0<\/p>\n<p class=\"mol-para-with-font\">In August 2023,\u00a0Axonis Therapeutics launched frozen vials of their viral vector, mature neurons and\u00a0astrocytes &#8211; or cells that hold nerve cells in place and help them develop &#8211; toward the ISS aboard a cargo resupply mission.\u00a0<\/p>\n<p class=\"mol-para-with-font\">A crew of researchers on the floating laboratory then injected these materials into a machine called\u00a0BioCell, which is a specialized cell-culturing system.<\/p>\n<p class=\"mol-para-with-font\">They loaded the viral vector with a fluorescent protein gene. If it successfully infiltrated the neurons and implanted the gene inside them, they would glow neon green.\u00a0\u00a0<\/p>\n<p class=\"mol-para-with-font\">Within just 72 hours, the cells had not only organized themselves into three-dimensional human brain organoids, but were also glowing.\u00a0<\/p>\n<div class=\"artSplitter mol-img-group\" style=\"\">\n<div class=\"mol-img\">\n<div class=\"image-wrap\"> <img decoding=\"async\" id=\"i-2ce2bde38a9d8976\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2024\/11\/22\/15\/92379525-14114651-NASA_astronaut_Mike_Barratt_processes_brain_organoid_samples_abo-a-6_1732291136720.jpg\" height=\"423\" width=\"634\" alt=\"NASA astronaut Mike Barratt processes brain organoid samples aboard the ISS for a different research project conducted this year\" class=\"blkBorder img-share\" style=\"max-width:100%\" loading=\"lazy\" \/> <\/div>\n<p> <noscript> <img loading=\"lazy\" decoding=\"async\" id=\"i-2ce2bde38a9d8976\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2024\/11\/22\/15\/92379525-14114651-NASA_astronaut_Mike_Barratt_processes_brain_organoid_samples_abo-a-6_1732291136720.jpg\" height=\"423\" width=\"634\" alt=\"NASA astronaut Mike Barratt processes brain organoid samples aboard the ISS for a different research project conducted this year\" class=\"blkBorder img-share\" \/> <\/noscript> <\/div>\n<p class=\"imageCaption\">\u00a0NASA astronaut Mike Barratt processes brain organoid samples aboard the ISS for a different research project conducted this year\u00a0<\/p>\n<\/div>\n<div class=\"artSplitter mol-img-group\" style=\"\">\n<div class=\"mol-img\">\n<div class=\"image-wrap\"> <img decoding=\"async\" id=\"i-c7f64985389a51f1\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2024\/11\/22\/15\/92379625-14114651-ISS_researchers_used_a_specialized_cell_culturing_system_called_-a-5_1732291101507.jpg\" height=\"543\" width=\"634\" alt=\"ISS researchers used a specialized cell-culturing system called BioCell to grow the brain organelles and test the effectiveness of the viral vector\" class=\"blkBorder img-share\" style=\"max-width:100%\" loading=\"lazy\" \/> <\/div>\n<p> <noscript> <img loading=\"lazy\" decoding=\"async\" id=\"i-c7f64985389a51f1\" src=\"https:\/\/i.dailymail.co.uk\/1s\/2024\/11\/22\/15\/92379625-14114651-ISS_researchers_used_a_specialized_cell_culturing_system_called_-a-5_1732291101507.jpg\" height=\"543\" width=\"634\" alt=\"ISS researchers used a specialized cell-culturing system called BioCell to grow the brain organelles and test the effectiveness of the viral vector\" class=\"blkBorder img-share\" \/> <\/noscript> <\/div>\n<p class=\"imageCaption\">ISS researchers used a specialized cell-culturing system called BioCell to grow the brain organelles and test the effectiveness of the viral vector\u00a0<\/p>\n<\/div>\n<p class=\"mol-para-with-font\">&#8216;The pivotal day was when the crew was doing the microscopy, and we saw big aggregates of green, glowing 3D tissue,&#8217; said researcher Sheila Nielsen of BioServe Space Technologies, the research organization that created BioCell.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;Shane and I were sending images of the organoids back and forth to each other, and we were pretty ecstatic because this is not something they had ever seen on the ground,&#8217; she added in the statement.\u00a0<\/p>\n<p class=\"mol-para-with-font\">Viruses are very efficient at infecting cells and inserting genetic material into them.\u00a0<\/p>\n<p class=\"mol-para-with-font\">This is how they sicken their hosts &#8211; the inserted genetic material damages cells and allows the virus to reproduce, eliciting an immune response.\u00a0<\/p>\n<p class=\"mol-para-with-font\">But scientists can reprogram viruses to carry beneficial gene therapies to cells, providing a targeted treatment for disease or injury.\u00a0<\/p>\n<p class=\"mol-para-with-font\">This study demonstrated that\u00a0Axonis Therapeutics&#8217; viral vector would be able to deliver gene therapy to human neurons.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;It was very exciting &#8211; we were able to both validate the gene therapy targeting ability and show that we indeed rapidly formed 3D assembloid models of the human brain,&#8217; Hegarty said.\u00a0<\/p>\n<p class=\"mol-para-with-font\">&#8216;The major breakthrough is that you can self-assemble mature neurons and astrocytes rapidly into a model of the brain in microgravity conditions, which you can&#8217;t do on the ground.&#8217;\u00a0<\/p>\n<\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.dailymail.co.uk\/sciencetech\/article-14114651\/Scientists-grow-human-brains-space-time-help-cure-worlds-killer-disease.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists\u00a0have grown tiny human brains in space to research new treatments for Alzheimer&#8217;s, Parkinson&#8217;s and spinal injuries. The low gravity environment on the International Space Station (ISS) enabled researchers to &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=129163\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-129163","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/129163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=129163"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/129163\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=129163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=129163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=129163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}