{"id":130150,"date":"2024-11-26T04:28:44","date_gmt":"2024-11-25T21:28:44","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=130150"},"modified":"2024-11-26T04:28:44","modified_gmt":"2024-11-25T21:28:44","slug":"new-platform-overcomes-blood-brain-barrier-for-drug-delivery","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=130150","title":{"rendered":"New Platform Overcomes Blood-Brain Barrier for Drug Delivery"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier. The innovative blood-brain barrier-crossing conjugate (BCC) platform utilizes a biological process called \u03b3-secretase-mediated transcytosis to safely transport drugs like oligonucleotides and proteins into the central nervous system via intravenous injection.<\/p>\n<p>In mouse models and human brain tissue, the system effectively silenced harmful genes linked to diseases such as ALS and Alzheimer\u2019s without causing significant side effects. This advancement could revolutionize treatments for neurological and psychiatric disorders, solving a critical challenge in brain research.<\/p>\n<p><strong>Key Facts<\/strong>:<\/p>\n<ul class=\"wp-block-list\">\n<li>The BCC system uses \u03b3-secretase-mediated transcytosis to bypass the blood-brain barrier.<\/li>\n<li>It successfully delivered drugs targeting harmful genes in ALS and Alzheimer\u2019s disease.<\/li>\n<li>The treatment was well-tolerated and effective in both mouse models and human brain tissue.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Mount Sinai Hospital<\/p>\n<p><strong>Researchers at the Icahn School of Medicine at Mount Sinai have developed an innovative approach\u2014demonstrated in mouse models and isolated human brain tissue\u2014to safely and effectively deliver therapeutics into the brain, providing new possibilities for treating a wide range of neurological and psychiatric diseases.<\/strong><\/p>\n<p>Published in the November 25 online issue of\u00a0<em>Nature Biotechnology<\/em>, the study introduces a first-of-its-kind blood-brain barrier-crossing conjugate (BCC) system, designed to overcome the protective barrier that typically blocks large biomolecules from reaching the central nervous system (CNS).<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106506\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"799\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience.jpg\" alt=\"This shows a brain.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/11\/BBB-neurotech-drug-Delivery-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The blood-brain barrier is a natural protective shield that prevents harmful substances from entering the brain. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The blood-brain barrier is a natural protective shield that prevents harmful substances from entering the brain. However, it also blocks the delivery of life-saving drugs, creating a significant challenge in treating conditions like amyotrophic lateral sclerosis (ALS), Alzheimer\u2019s disease, addiction, and many other CNS disorders.<\/p>\n<p>The BCC platform takes advantage of a specialized biological process called \u03b3-secretase-mediated transcytosis to deliver large therapeutic molecules, like oligonucleotides and proteins, directly into the brain through a simple intravenous injection.<\/p>\n<p>\u201cThe blood-brain barrier is an essential defense mechanism, but it also presents a significant challenge for delivering drugs to the brain,\u201d says co-corresponding senior author\u00a0Yizhou Dong, PhD, Professor of Immunology and Immunotherapy, and a member of the\u202fIcahn Genomics Institute\u202fand the Marc and Jennifer Lipschultz Precision Immunology Institute, at Icahn Mount Sinai.<\/p>\n<p>\u201cOur BCC platform breaks this barrier, allowing biomacromolecules, including oligonucleotides, to reach the CNS safely and efficiently.\u201d<\/p>\n<p>The study showed that when the researchers injected a compound called BCC10 linked to specialized genetic tools known as antisense oligonucleotides into mice, it successfully reduced the activity of harmful genes in the brain.<\/p>\n<p>In a transgenic mouse model of ALS (a motor neuron disease), the treatment significantly lowered levels of the disease-causing gene called\u00a0<em>Sod1<\/em>\u00a0and its associated protein.<\/p>\n<p>Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene,\u00a0<em>Mapt<\/em>, which encodes the tau protein and is a target for the treatment of Alzheimer\u2019s disease and other dementias.<\/p>\n<p>BCC10 proved to be highly effective at delivering these genetic tools to the brain, improving their ability to silence harmful genes in different models and even in samples of excised human brain tissue studied in the laboratory.<\/p>\n<p>Importantly, the treatment was well tolerated in mice, causing little or no damage to major organs at the tested doses, say the investigators.<\/p>\n<p>Despite recent progress in the field, there is still a pressing need for technologies that can bypass the blood-brain barrier and improve the delivery of biomacromolecule-based therapies to the central nervous system via systemic administration.<\/p>\n<p>\u201cOur platform could potentially solve one of the biggest hurdles in brain research\u2014getting large therapeutic molecules past the blood-brain barrier safely and efficiently,\u201d says co-corresponding senior author\u00a0Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience, Director of The Friedman Brain Institute, and Dean for Academic Affairs of Icahn Mount Sinai, and Chief Scientific Officer of the Mount Sinai Health System.<\/p>\n<p>\u201cThis development has the potential to advance treatments for a broad range of brain diseases.\u201d<\/p>\n<p>Next, the investigators plan to conduct further studies in large animal models to validate the platform and develop its therapeutic potential.<\/p>\n<p>The paper is titled \u201cIntravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system.\u201d<\/p>\n<p>The remaining authors, all with Icahn Mount Sinai except where indicated, are Chang Wang, MD; Siyu Wang, PhD; Yonger Xue, PhD; Yichen Zhong, BS (PhD Candidate); Haoyuan Li, MD; Xucheng Hou, PhD; Diana D. Kang, BS (PhD Candidate\/Icahn Mount Sinai and Ohio State University); Zhengwei Liu, PhD; Meng Tian, PhD; Leiming Wang, PhD; Dinglingge Cao, PhD; Yang Yu, PhD (Ohio State University), Jayce Liu, BS (PhD Candidate, Ohio State University), Xiaolin Cheng, PhD (Ohio State University), Tamara Markovic, PhD; Alice Hashemi, BS; Brian H. Kopell, MD, and Alexander W. Charney, MD, PhD.<\/p>\n<h2 class=\"wp-block-heading\">About this neurology and neuroscience research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#177c76657e793972647c7279766d7e577a64647a39727362\" target=\"_blank\" rel=\"noreferrer noopener\">Karin Eskenazi<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/mssm.edu\" target=\"_blank\" rel=\"noreferrer noopener\">Mount Sinai Hospital<\/a><br \/><strong>Contact: <\/strong>Karin Eskenazi \u2013 Mount Sinai Hospital<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Closed access.<br \/>\u201c<a href=\"https:\/\/dx.doi.org\/10.1038\/s41587-024-02487-7\" target=\"_blank\" rel=\"noreferrer noopener\">Intravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system<\/a>\u201d by Yizhou Dong et al. <em>Nature Biotechnology<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Intravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system<\/strong><\/p>\n<p>Delivery of biomacromolecules to the central nervous system (CNS) remains challenging because of the restrictive nature of the blood\u2013brain barrier (BBB). We developed a BBB-crossing conjugate (BCC) system that facilitates delivery into the CNS through \u03b3-secretase-mediated transcytosis.<\/p>\n<p>Intravenous administration of a BCC10\u2013oligonucleotide conjugate demonstrated effective transportation of the oligonucleotide across the BBB and gene silencing in wild-type mice, human brain tissues and an amyotrophic lateral sclerosis mouse model.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/neuropharmacology-bbb-21827\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier. The innovative blood-brain barrier-crossing conjugate (BCC) platform utilizes &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=130150\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-130150","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/130150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=130150"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/130150\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=130150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=130150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=130150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}