{"id":132938,"date":"2024-12-03T19:36:54","date_gmt":"2024-12-03T12:36:54","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=132938"},"modified":"2024-12-03T19:36:54","modified_gmt":"2024-12-03T12:36:54","slug":"parkinsons-link-to-gut-bacteria-suggests-an-unexpected-simple-treatment-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=132938","title":{"rendered":"Parkinson&#8217;s Link to Gut Bacteria Suggests an Unexpected, Simple Treatment : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Researchers have suspected for<a href=\"https:\/\/www.sciencealert.com\/new-evidence-suggests-parkinson-s-might-start-in-the-gut-before-spreading-to-the-brain\"> some time<\/a> that the link between our gut and brain plays a role in the development of  <a href=\"https:\/\/www.sciencealert.com\/go\/IYl\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73029\" data-postid=\"145436\" rel=\"nofollow noopener\" target=\"_self\">Parkinson&#8217;s<\/a> disease.<\/p>\n<p>A recent study identified gut microbes likely to be involved and linked them with decreased <a href=\"https:\/\/en.wikipedia.org\/wiki\/Riboflavin\">riboflavin<\/a> ( <a href=\"https:\/\/www.sciencealert.com\/what-are-vitamins-and-do-we-really-need-to-take-them\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73116\" data-postid=\"145436\" rel=\"nofollow noopener\" target=\"_self\">vitamin<\/a> B2) and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Biotin\">biotin<\/a> (vitamin B7), pointing the way to an unexpectedly <a href=\"https:\/\/youtu.be\/9wuwZbPf0Vs\">simple treatment that may help<\/a>: B  <a href=\"https:\/\/www.sciencealert.com\/what-are-vitamins-and-do-we-really-need-to-take-them\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73116\" data-postid=\"145436\" rel=\"nofollow noopener\" target=\"_self\">vitamins<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Supplementation of riboflavin and\/or biotin is likely to be beneficial in a subset of Parkinson&#8217;s disease patients, in which gut dysbiosis plays pivotal roles,&#8221; Nagoya University medical researcher Hiroshi Nishiwaki and colleagues <a href=\"https:\/\/doi.org\/10.1038\/s41531-024-00724-z\">write<\/a> in their paper published in May.<\/p>\n<p><iframe loading=\"lazy\" title=\"Parkinson&#039;s Link to Gut Bacteria Hints at Simple Treatment\" width=\"1170\" height=\"658\" src=\"https:\/\/www.youtube.com\/embed\/9wuwZbPf0Vs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe> frameborder=&#8221;0\u2033 allow=&#8221;accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share&#8221; referrerpolicy=&#8221;strict-origin-when-cross-origin&#8221; allowfullscreen&gt;<\/iframe><\/p>\n<p>The neurodegenerative disease impacts <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/parkinson-disease\">almost 10 million people globally<\/a>, who at best can hope for <a href=\"https:\/\/www.sciencealert.com\/this-is-the-first-time-drug-shows-signs-of-slowing-parkinsons-disease\">therapies that slow and alleviate symptoms<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Symptoms typically begin with constipation and sleep problems, up to 20 years before progressing into dementia and the debilitating loss of muscle control.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p><a href=\"https:\/\/www.sciencealert.com\/changes-in-gut-bacteria-are-present-long-before-signs-of-parkinsons-appear\">Previous research<\/a> found people with Parkinson&#8217;s disease also experience changes in their microbiome long before other signs appear.<\/p>\n<figure id=\"attachment_131231\" aria-describedby=\"caption-attachment-131231\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/06\/SHakingHandPIckingUpGlass-1.jpg\" alt=\"Hands picking up a glass\" width=\"642\" height=\"500\" class=\"size-full wp-image-131231\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/06\/SHakingHandPIckingUpGlass-1.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/06\/SHakingHandPIckingUpGlass-1-533x415.jpg 533w, https:\/\/www.sciencealert.com\/images\/2024\/06\/SHakingHandPIckingUpGlass-1-600x467.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-131231\" class=\"wp-caption-text\">Parkinson&#8217;s disease impacts almost 10 million people globally. (<a href=\"https:\/\/www.canva.com\/photos\/MAEGCRiWJIk\/\">pixelshot\/Canva Pro<\/a>)<\/figcaption><\/figure>\n<p>Analyzing fecal samples from 94 patients with Parkinson&#8217;s disease and 73 relatively healthy controls in Japan, Nishiwaki and team compared their results with data from China, Taiwan, Germany, and the US.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>While different groups of bacteria were involved in the different countries examined, they all influenced pathways that synthesize B vitamins in the body.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The researchers found the changes in gut bacteria communities were associated with a decrease in <a href=\"https:\/\/en.wikipedia.org\/wiki\/Riboflavin\">riboflavin<\/a> and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Biotin\">biotin<\/a> in people with Parkinson&#8217;s disease.<\/p>\n<figure id=\"attachment_145467\" aria-describedby=\"caption-attachment-145467\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/12\/ParkinsonsGutBVitamins642.jpg\" alt=\"Graphic of human gut-brain connection and B vitamins\" width=\"642\" height=\"442\" class=\"size-full wp-image-145467\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/12\/ParkinsonsGutBVitamins642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/12\/ParkinsonsGutBVitamins642-603x415.jpg 603w, https:\/\/www.sciencealert.com\/images\/2024\/12\/ParkinsonsGutBVitamins642-600x413.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-145467\" class=\"wp-caption-text\">In Parkinson&#8217;s disease, a reduction in the gut bacteria of genes responsible for synthesizing the essential B vitamins B2 and B7 was found. (<a href=\"https:\/\/www.nagoya-u.ac.jp\/researchinfo\/result-en\/2024\/06\/20240618-01.html\">Reiko Matsushita<\/a>)<\/figcaption><\/figure>\n<p>Nishiwaki and colleagues then showed the lack of B vitamins was linked to a decrease in <a href=\"https:\/\/en.wikipedia.org\/wiki\/Short-chain_fatty_acid\">short-chain fatty acids<\/a> (SCFAs) and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Polyamine\">polyamines<\/a>: molecules that help create a healthy mucus layer in the intestines.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Deficiencies in polyamines and SCFAs could lead to thinning of the intestinal mucus layer, increasing intestinal permeability, both of which have been observed in Parkinson&#8217;s disease,&#8221; Nishiwaki <a href=\"https:\/\/www.nagoya-u.ac.jp\/researchinfo\/result-en\/2024\/06\/20240618-01.html\">explains<\/a>.<\/p>\n<figure id=\"attachment_131227\" aria-describedby=\"caption-attachment-131227\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/06\/GraphicOfParkinsonsVitaminBConnection642.jpg\" alt=\"A graphic depicting the process of gut bacteria depleting B vitamins and leading to symptoms of Parkinson's disease\" width=\"642\" height=\"950\" class=\"wp-image-131227 size-full\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/06\/GraphicOfParkinsonsVitaminBConnection642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/06\/GraphicOfParkinsonsVitaminBConnection642-280x415.jpg 280w, https:\/\/www.sciencealert.com\/images\/2024\/06\/GraphicOfParkinsonsVitaminBConnection642-600x888.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-131227\" class=\"wp-caption-text\">Summary of findings from the study and speculations from previous research. (Nishiwaki et al., <a href=\"https:\/\/doi.org\/10.1038\/s41531-024-00724-z\"><em>npj Parkinson&#8217;s Disease<\/em><\/a>, 2024)<\/figcaption><\/figure>\n<p>They suspect the weakened protective layer exposes the intestinal nervous system to more of the toxins we now encounter more regularly. These include <a href=\"https:\/\/www.sciencealert.com\/dry-cleaning-chemical-could-be-major-cause-of-parkinsons-scientists-warn\">cleaning chemicals,<\/a> <a href=\"https:\/\/www.sciencealert.com\/two-pathways-to-parkinsons-could-point-to-a-single-way-to-prevent-it\">pesticides<\/a>, and herbicides.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Such toxins lead to the overproduction of \u03b1-synuclein fibrils \u2013 molecules <a href=\"https:\/\/doi.org\/10.1016\/j.nbd.2024.106411\">known to amass<\/a> in <a href=\"https:\/\/www.sciencealert.com\/new-test-detects-parkinsons-7-years-before-most-symptoms-show\">dopamine-producing cells<\/a> in the <a href=\"https:\/\/www.sciencealert.com\/scientists-pinpoint-exactly-which-brain-cells-die-in-parkinson-s-disease\">substantia nigra<\/a> part of our brains, and increased nervous system inflammation, eventually leading to the more debilitating motor and dementia symptoms of Parkinson&#8217;s.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>A <a href=\"https:\/\/www.scielo.br\/j\/bjmbr\/a\/BM4WLJBtjxF8Cx3wFsjFhKb\/?lang=en\">2003 study<\/a> found high doses of riboflavin can assist in recovering some motor functions in patients who also eliminated red meat from their diets.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>So it&#8217;s possible that high doses of vitamin B may prevent some of the damage, Nishiwaki and team propose.<\/p>\n<figure id=\"attachment_131228\" aria-describedby=\"caption-attachment-131228\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/06\/VitaminBInBlood642.jpg\" alt=\"Illustration of a vitamin B2 molecule in the blood. \" width=\"642\" height=\"424\" class=\"size-medium wp-image-131228\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/06\/VitaminBInBlood642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/06\/VitaminBInBlood642-628x415.jpg 628w, https:\/\/www.sciencealert.com\/images\/2024\/06\/VitaminBInBlood642-600x396.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\"\/><figcaption id=\"caption-attachment-131228\" class=\"wp-caption-text\">Illustration of a riboflavin (B2) molecule in the blood. (Nemes Laszlo\/Science Photo Library\/Getty Images)<\/figcaption><\/figure>\n<p>This all suggests ensuring patients have healthy gut microbiomes may also prove protective, as would <a href=\"https:\/\/www.hopkinsmedicine.org\/health\/conditions-and-diseases\/parkinsons-disease\/can-environmental-toxins-cause-parkinson-disease\">reducing the toxic pollutants<\/a> in our environment.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Of course, with such a complicated chain of events involved in Parkinson&#8217;s disease, not all patients likely experience the same causes, so each individual would need to be assessed.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We could perform gut microbiota analysis on patients or conduct fecal metabolite analysis,&#8221; <a href=\"https:\/\/www.nagoya-u.ac.jp\/researchinfo\/result-en\/2024\/06\/20240618-01.html\">explains<\/a> Nishiwak.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Using these findings, we could identify individuals with specific deficiencies and administer oral riboflavin and biotin supplements to those with decreased levels, potentially creating an effective treatment.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>This research was published in <a href=\"https:\/\/doi.org\/10.1038\/s41531-024-00724-z\"><em>npj Parkinson&#8217;s Disease<\/em><\/a>.<\/p>\n<p><em>An earlier version of this article was published in June 2024.<\/em><\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/parkinsons-link-to-gut-bacteria-suggests-an-unexpected-simple-treatment\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have suspected for some time that the link between our gut and brain plays a role in the development of Parkinson&#8217;s disease. A recent study identified gut microbes likely &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=132938\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-132938","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/132938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=132938"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/132938\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=132938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=132938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=132938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}