{"id":133213,"date":"2024-12-04T12:54:32","date_gmt":"2024-12-04T05:54:32","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=133213"},"modified":"2024-12-04T12:54:32","modified_gmt":"2024-12-04T05:54:32","slug":"cannabis-use-linked-to-epigenetic-changes-study-finds-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=133213","title":{"rendered":"Cannabis Use Linked to Epigenetic Changes, Study Finds : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Using cannabis may cause changes in the human body&#8217;s epigenome, a study of over 1,000 adults suggests. The <a href=\"https:\/\/www.sciencealert.com\/epigenetic-changes\">epigenome<\/a> functions like a set of switches, activating or deactivating genes to change how our bodies function.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We observed associations between cumulative marijuana use and multiple epigenetic markers across time,&#8221; <a href=\"https:\/\/news.feinberg.northwestern.edu\/2023\/07\/18\/marijuana-use-linked-to-epigenetic-changes\/\">explained<\/a> epidemiologist Lifang Hou from Northwestern University <a href=\"https:\/\/news.feinberg.northwestern.edu\/2023\/07\/18\/marijuana-use-linked-to-epigenetic-changes\/\"\/> when the research was published in 2023.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabis_(drug)\">Cannabis<\/a> is a <a href=\"https:\/\/www.sciencealert.com\/daily-cannabis-use-overtakes-alcohol-for-first-time-in-the-us\">commonly used substance in the United States<\/a>, with 49 percent of people trying it at least once, Hou and a team of US researchers report in their <a href=\"https:\/\/doi.org\/10.1038\/s41380-023-02106-y\">published paper<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Some US states and <a href=\"https:\/\/www.sciencealert.com\/australia-s-capital-just-legalised-recreational-marijuana-in-defiance-of-federal-laws\">other countries<\/a> have made cannabis legal, but we still don&#8217;t fully understand its <a href=\"https:\/\/www.sciencealert.com\/first-major-study-links-cannabis-use-disorder-to-deadly-cancers\">effects on our health<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The researchers studied around 1,000 adults who had participated in a long-term previous study where they had been asked about their cannabis use over a 20-year period.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Study participants provided blood samples on two occasions during that time, at the 15- and 20-year points. They were aged between 18 and 30 at baseline, or &#8216;year 0&#8217;.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Using these blood samples from five years apart, Hou and her team looked at the  <a href=\"https:\/\/www.sciencealert.com\/epigenetic-changes\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73027\" data-postid=\"145397\" rel=\"nofollow noopener\" target=\"_self\">epigenetic changes<\/a>, specifically <a href=\"https:\/\/en.wikipedia.org\/wiki\/DNA_methylation\">DNA methylation<\/a> levels, of people who had used cannabis recently or for a long time.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The addition or removal of <a href=\"https:\/\/en.wikipedia.org\/wiki\/Methyl_group\">methyl groups<\/a> from DNA is one of the most studied epigenetic modifications. Without changing the genomic sequence, it changes the activity of genes, because it&#8217;s harder for cells to read the genome instruction manual with these molecular changes in their way.<\/p>\n<figure id=\"attachment_137472\" aria-describedby=\"caption-attachment-137472\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/09\/StructureOfChromosomeDNAandMethylation_642.jpg\" alt=\"Diagram showing structure of our genetic molecules from chromosome to DNA including methylation\" width=\"642\" height=\"449\" class=\"size-full wp-image-137472\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/09\/StructureOfChromosomeDNAandMethylation_642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/09\/StructureOfChromosomeDNAandMethylation_642-593x415.jpg 593w, https:\/\/www.sciencealert.com\/images\/2024\/09\/StructureOfChromosomeDNAandMethylation_642-600x420.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-137472\" class=\"wp-caption-text\">When epigenetic factors, which can come from other genes or the environment inside a cell or beyond, recruit a methyl group, it changes the expression of our genes. (ttsz\/iStock\/Getty Images)<\/figcaption><\/figure>\n<p>Environmental and lifestyle factors can trigger these methylation changes, which can be <a href=\"https:\/\/www.sciencealert.com\/heres-how-events-in-your-grandparents-lives-could-affect-your-genes\">passed onto future generations<\/a>, and blood <a href=\"https:\/\/en.wikipedia.org\/wiki\/Biomarker\">biomarkers<\/a> can provide information about both recent and historical exposures.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We previously identified associations between marijuana use and the aging process as captured through DNA methylation,&#8221; Hou <a href=\"https:\/\/news.feinberg.northwestern.edu\/2023\/07\/18\/marijuana-use-linked-to-epigenetic-changes\/\">said<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We wanted to further explore whether specific epigenetic factors were associated with marijuana and whether these factors are related to health outcomes.&#8221;<\/p>\n<figure id=\"attachment_145404\" aria-describedby=\"caption-attachment-145404\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/MultipleGenerationsFamily642.jpg\" alt=\"A family of humans\" width=\"642\" height=\"429\" class=\"size-full wp-image-145404\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/MultipleGenerationsFamily642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/MultipleGenerationsFamily642-621x415.jpg 621w, https:\/\/www.sciencealert.com\/images\/2024\/11\/MultipleGenerationsFamily642-600x401.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-145404\" class=\"wp-caption-text\">Environmental and lifestyle factors can trigger methylation changes, which can be passed onto future generations. (<a href=\"https:\/\/www.canva.com\/photos\/MADYNemcmnI\/\">Monkey Business Images\/Canva<\/a>)<\/figcaption><\/figure>\n<p>The comprehensive data on the participants cannabis use allowed them to estimate cumulative use over time as well as recent use and compare it with DNA methylation markers in their blood for analysis.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>They found numerous DNA methylation markers in the 15-year blood samples, 22 that were associated with recent use, and 31 associated with cumulative cannabis use. In the samples taken at the 20-year point they identified 132 markers linked to recent use and 16 linked to cumulative use.<\/p>\n<figure id=\"attachment_137462\" aria-describedby=\"caption-attachment-137462\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/09\/CannabisPlantWithPurplishFlowers_642.jpg\" alt=\"Cannabis plant with its purple flowers\" width=\"642\" height=\"428\" class=\"wp-image-137462 size-full\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/09\/CannabisPlantWithPurplishFlowers_642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/09\/CannabisPlantWithPurplishFlowers_642-623x415.jpg 623w, https:\/\/www.sciencealert.com\/images\/2024\/09\/CannabisPlantWithPurplishFlowers_642-600x400.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-137462\" class=\"wp-caption-text\">The buds of a cannabis plant contain the most cannabinoids. (<a href=\"https:\/\/unsplash.com\/photos\/pink-and-green-petaled-flower-t9jQie6cUhg\">Esteban L\u00f3pez\/Unsplash<\/a>)<\/figcaption><\/figure>\n<p>&#8220;Interestingly, we consistently identified one marker that has previously been associated with tobacco use,&#8221; Hou <a href=\"https:\/\/news.feinberg.northwestern.edu\/2023\/07\/18\/marijuana-use-linked-to-epigenetic-changes\/\">explained<\/a>, &#8220;suggesting a potential shared epigenetic regulation between tobacco and marijuana use.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Multiple epigenetic changes associated with cannabis use had previously been linked to things like <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_proliferation\">cellular proliferation<\/a>, <a href=\"https:\/\/www.mycancergenome.org\/content\/pathways\/hormone-signaling\/\">hormone signaling<\/a>, infections, neurological disorders like  <a href=\"https:\/\/www.sciencealert.com\/schizophrenia\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73022\" data-postid=\"145397\" rel=\"nofollow noopener\" target=\"_self\">schizophrenia<\/a> and <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/bipolar-disorder\/symptoms-causes\/syc-20355955\">bipolar disorder<\/a>, and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Substance_use_disorder\">substance use disorders<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>It&#8217;s important to note that this study doesn&#8217;t prove that cannabis directly causes these changes or causes health problems.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;This research has provided novel insights into the association between marijuana use and epigenetic factors,&#8221; <a href=\"https:\/\/news.feinberg.northwestern.edu\/2023\/07\/18\/marijuana-use-linked-to-epigenetic-changes\/\">said <\/a>epidemiologist Drew Nannini from Northwestern University.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Additional studies are needed to determine whether these associations are consistently observed in different populations. Moreover, studies examining the effect of marijuana on age-related health outcomes may provide further insight into the long-term effect of marijuana on health.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The study has been published in <a href=\"https:\/\/doi.org\/10.1038\/s41380-023-02106-y\"><em>Molecular Psychiatry<\/em><\/a>.<\/p>\n<p><em>An earlier version of this article was published in July 2023.<\/em><\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/cannabis-use-linked-to-epigenetic-changes-study-finds\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using cannabis may cause changes in the human body&#8217;s epigenome, a study of over 1,000 adults suggests. The epigenome functions like a set of switches, activating or deactivating genes to &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=133213\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-133213","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/133213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=133213"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/133213\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=133213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=133213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=133213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}