{"id":133553,"date":"2024-12-05T10:17:50","date_gmt":"2024-12-05T03:17:50","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=133553"},"modified":"2024-12-05T10:17:50","modified_gmt":"2024-12-05T03:17:50","slug":"herbicide-exposure-linked-to-long-term-brain-inflammation-alzheimers","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=133553","title":{"rendered":"Herbicide Exposure Linked to Long-Term Brain Inflammation, Alzheimer&#8217;s"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>New research reveals that glyphosate, a widely used herbicide, can cause lasting brain inflammation and accelerate Alzheimer\u2019s-like pathology in mice. Even short-term exposure resulted in persistent inflammatory markers and neurological damage, including anxiety-like behaviors and premature death. The study found that glyphosate\u2019s metabolite, aminomethylphosphonic acid, accumulates in brain tissue, raising concerns about its long-term safety for humans.<\/p>\n<p>Researchers stress the need for further investigation into glyphosate\u2019s role in neurodegenerative diseases and its impact on public health. These findings challenge assumptions about the safety of glyphosate, highlighting its potential risks for brain health.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Glyphosate exposure causes persistent brain inflammation and neurodegenerative markers.<\/li>\n<li>Its metabolite accumulates in the brain, even after exposure ends.<\/li>\n<li>Findings suggest glyphosate could contribute to Alzheimer\u2019s and cognitive decline.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>Arizona State University<\/p>\n<p><strong>The human brain is an incredibly adaptable organ, often able to heal itself even from significant trauma. Yet for the first time, new research shows even brief contact with a common herbicide can cause lasting damage to the brain, which may persist long after direct exposure ends.<\/strong><\/p>\n<p>In a groundbreaking new study, Arizona State University researcher\u00a0Ramon Velazquez\u00a0and his colleagues at the Translational Genomics Research Institute (TGen), part of City of Hope, demonstrate that mice exposed to the herbicide glyphosate develop significant brain inflammation, which is associated with neurodegenerative disease.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106749\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience.jpg\" alt=\"This shows a brain and a bottle of herbicide.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/herbicide-neuroinflammation-alzheimers-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">Glyphosate exposure in mice also resulted in premature death and anxiety-like behaviors, which replicates findings by others examining glyphosate exposure in rodents. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>The findings suggest the brain may be much more susceptible to the damaging effects of the herbicide than previously thought. Glyphosate is one of the most pervasive herbicides used in the U.S. and worldwide.<\/p>\n<p>The research, which appears today in the\u00a0<em>Journal of Neuroinflammation<\/em>,\u00a0identifies an association between glyphosate exposure in mice and symptoms of neuroinflammation, as well as accelerated Alzheimer\u2019s disease-like pathology.\u00a0<\/p>\n<p>This study tracks both the presence and impact of glyphosate\u2019s byproducts in the brain long after exposure ends, showing an array of persistent, damaging effects on brain health.<\/p>\n<p>Glyphosate exposure in mice also resulted in premature death and anxiety-like behaviors, which replicates findings by others examining glyphosate exposure in rodents. Further, the scientists discovered these symptoms persisted even after a 6-month recovery period during which exposure was discontinued.<\/p>\n<p>Additionally, the investigation demonstrated that a byproduct of glyphosate \u2014aminomethylphosphonic acid\u2014accumulated in brain tissue, raising serious concerns about the chemical\u2019s safety for human populations.\u00a0<\/p>\n<p>\u201cOur work contributes to the growing literature highlighting the brain\u2019s vulnerability to glyphosate,\u201d Velazquez says.<\/p>\n<p>\u201cGiven the increasing incidence of cognitive decline in the aging population, particularly in rural communities where exposure to glyphosate is more common\u00a0due to large-scale farming, there is an urgent need for more basic research on the effects of this herbicide.\u201d<\/p>\n<p>Velazquez is a researcher with the\u00a0ASU-Banner Neurodegenerative Disease Research Center\u00a0at the ASU Biodesign Institute and an assistant professor with the\u00a0School of Life Sciences.<\/p>\n<p>He is joined by first author\u00a0Samantha K. Bartholomew,\u00a0 a PhD candidate in the Velazquez Lab, other ASU colleagues, and co-senior author Patrick Pirrotte, associate professor with the Translational Genomics Research Institute (TGen) and researcher with the City of Hope Comprehensive Cancer Center in California.<\/p>\n<p>According to the\u00a0Centers for Disease Research, farm laborers, landscape workers, and others employed in agriculture are more likely to be exposed to glyphosate through inhalation or skin contact.<\/p>\n<p>Additionally, the new findings suggest that ingestion of glyphosate residues on foods sprayed with the herbicide potentially poses a health hazard. Most people living in the U.S. have been exposed to glyphosate during their lifetime.<\/p>\n<p>\u201cMy hope is that our work drives further investigation into the effects of glyphosate exposure, which may lead to a reexamination of its long-term safety and perhaps spark discussion about other prevalent toxins in our environment that may affect the brain,\u201d Bartholomew says.<\/p>\n<p>The team\u2019s findings build on\u00a0earlier ASU research\u00a0that demonstrates a link between glyphosate exposure and a heightened risk for neurodegenerative disorders.<\/p>\n<p>The previous study showed that glyphosate crosses the blood-brain barrier, a protective layer that typically prevents potentially harmful substances from entering the brain. Once glyphosate crosses this barrier, it can interact with brain tissue and appears to contribute to neuroinflammation and other harmful effects on neural function.<\/p>\n<p>The EPA considers certain levels of glyphosate safe for human exposure, asserting that the chemical is minimally absorbed into the body and is primarily excreted unchanged.<\/p>\n<p>However, recent studies, including this one, indicate that glyphosate, and its major metabolite aminomethylphosphonic acid, can persist in the body and accumulate in brain tissue over time, raising questions about existing safety thresholds and whether glyphosate use is safe at all.<\/p>\n<p><strong>Herbicide may attack more than weeds<\/strong><\/p>\n<p>Glyphosate is the world\u2019s most heavily applied herbicide, used on crops including corn, soybeans, sugar beets, alfalfa, cotton and wheat. Since the introduction of glyphosate-tolerant crops (genetically engineered to be sprayed with glyphosate without dying) in 1996, glyphosate usage has surged, with applications predominately in agricultural settings.<\/p>\n<p>The U.S. Geological Survey notes approximately 300 million pounds of glyphosate are used annually in the United States alone.\u00a0\u00a0Although glyphosate levels are regulated on foods imported into the United States, enforcement and specific limits can vary. Due to its widespread use, the chemical is found throughout the food chain. It persists in the air, accumulates in soils, and is found in surface and groundwater.<\/p>\n<p>Despite being considered safe by the EPA, the International Agency for Research on Cancer classifies glyphosate as \u201cpossibly carcinogenic to humans,\u201d and emerging research, including this study, points to its potential role in worsening neurodegenerative diseases by contributing to pathologies, like those seen in Alzheimer\u2019s disease.<\/p>\n<p>The chemical works by inhibiting a specific enzyme pathway in plants that is crucial for producing essential amino acids. However, its impact extends beyond the intended weed, grass and plant targets, negatively affecting the biological systems in mammals, as demonstrated by its persistence in brain tissue and its role in inflammatory processes.<\/p>\n<p>\u201cHerbicides are used heavily and ubiquitously around the world,\u201d says Pirrotte, associate professor in TGen\u2019s Early Detection and Prevention Division, director of the Integrated Mass Spectrometry Shared Resource at TGen and City of Hope, and senior author of the paper.<\/p>\n<p>\u201cThese findings highlight that many chemicals we regularly encounter, previously considered safe, may pose potential health risks. However, further research is needed to fully assess the public health impact and identify safer alternatives.\u201d<\/p>\n<p><strong>Is glyphosate safe to use at all?<\/strong><\/p>\n<p>The researchers hypothesized that\u00a0glyphosate exposure would induce neuroinflammation in control mice and worsen neuroinflammation in Alzheimer\u2019s model mice, causing elevated Amyloid-\u03b2 and tau pathology and worsening spatial cognition after recovery.<\/p>\n<p>Amyloid-\u03b2 and Tau are key proteins that comprise plaques and tau tangles, the classic diagnostic markers of Alzheimer\u2019s disease. Plaques and tangles disrupt neural functioning and are directly linked to memory loss and cognitive decline.<\/p>\n<p>The experiments were conducted over 13 weeks, followed by a six-month recovery period. The main metabolite, aminomethylphosphonic acid, was detected in the brains of both normal and transgenic mice with Alzheimer\u2019s pathology.<\/p>\n<p>Transgenic mice are genetically modified to carry genes that cause them to develop Alzheimer\u2019s-like symptoms as they age. This allows researchers to study the progression and effects of the disease in a controlled laboratory setting.<\/p>\n<p>The researchers tested two levels of glyphosate exposure: a high dose, similar to levels used in earlier research, and a lower dose that is close to the limit used to establish the current acceptable dose in humans.<\/p>\n<p>This lower dose still led to harmful effects in the brains of mice, even after exposure ceased for months. While reports show that most Americans are exposed to glyphosate daily, these results show that even a short period could potentially cause neurological damage.<\/p>\n<p>Glyphosate caused a persistent increase in inflammatory markers in the brain and blood, even after the recovery period. This prolonged inflammation could drive the progression of neurodegenerative diseases, including Alzheimer\u2019s, indicating even temporary glyphosate exposure can lead to enduring inflammatory processes that affect brain health.<\/p>\n<p>The data emphasizes that glyphosate exposure may be a significant health concern for human populations.\u00a0The researchers stress the need for continued vigilance and intensified surveillance of glyphosate neurological and other long-term negative health effects.<\/p>\n<p>\u201cOur goal is to identify environmental factors that contribute to the rising prevalence of cognitive decline and neurodegenerative diseases in our society,\u201d Velazquez says.<\/p>\n<p>\u201cBy unveiling such factors, we can develop strategies to minimize exposures, ultimately improving the quality of life for the growing aging population.\u201d<\/p>\n<p><strong>Funding: <\/strong>The National Institutes on Aging, National Cancer Institute of the National Institutes of Health, and ASU Biodesign Institute funded this study.<\/p>\n<h2 class=\"wp-block-heading\">About this neurology research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#fba89a959f899ad5b79e9a959f9e89bb9a888ed59e9f8e\" target=\"_blank\" rel=\"noreferrer noopener\">Sandy Leander<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/asu.edu\" target=\"_blank\" rel=\"noreferrer noopener\">Arizona State University<\/a><br \/><strong>Contact: <\/strong>Sandy Leander \u2013 Arizona State University<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/dx.doi.org\/10.1186\/s12974-024-03290-6\" target=\"_blank\" rel=\"noreferrer noopener\">Glyphosate exposure exacerbates neuroinflammation 1 and Alzheimer\u2019s disease-like 2 pathology despite a 6-month recovery period in mice<\/a>\u201d by Ramon Velazquez et al. <em>Journal of Neuroinflammation<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Glyphosate exposure exacerbates neuroinflammation 1 and Alzheimer\u2019s disease-like 2 pathology despite a 6-month recovery period in mice<\/strong><\/p>\n<h3 class=\"wp-block-heading\">Background<\/h3>\n<p>Glyphosate use in the United States (US) has increased each year since the introduction of glyphosate-tolerant crops in 1996, yet little is known about its effects on the brain. We recently found that C57BL\/6J mice dosed with glyphosate for 14 days showed glyphosate and its major metabolite aminomethylphosphonic acid present in brain tissue, with corresponding increases in pro-inflammatory cytokine tumor necrosis factor-\u237a (TNF-\u237a) in the brain and peripheral blood plasma.<\/p>\n<p>Since TNF-\u237a is elevated in neurodegenerative disorders such as Alzheimer\u2019s Disease (AD), in this study, we asked whether glyphosate exposure serves as an accelerant of AD pathogenesis. Additionally, whether glyphosate and aminomethylphosphonic acid remain in the brain after a recovery period has yet to be examined.<\/p>\n<h3 class=\"wp-block-heading\">Methods<\/h3>\n<p>We hypothesized that glyphosate exposure would induce neuroinflammation in control mice, while exacerbating neuroinflammation in AD mice, causing elevated Amyloid-\u03b2 and tau pathology and worsening spatial cognition after recovery. We dosed 4.5-month-old 3xTg-AD and non-transgenic (NonTg) control mice with either 0, 50 or 500\u00a0mg\/kg of glyphosate daily for 13 weeks followed by a 6-month recovery period.<\/p>\n<h3 class=\"wp-block-heading\">Results<\/h3>\n<p>We found that aminomethylphosphonic acid was detectable in the brains of 3xTg-AD and NonTg glyphosate-dosed mice despite the 6-month recovery. Glyphosate-dosed 3xTg-AD mice showed reduced survival, increased thigmotaxia in the Morris water maze, significant increases in the beta secretase enzyme\u00a0(BACE-1) of amyloidogenic processing, amyloid-\u03b2\u00a0(A\u03b2) 42 insoluble fractions, A\u03b2 42\u00a0plaque load and plaque size, and phosphorylated tau (pTau) at epitopes Threonine 181, Serine 396, and AT8 (Serine 202, Threonine 205).<\/p>\n<p>Notably, we found increased pro- and anti-inflammatory cytokines and chemokines persisting in both 3xTg-AD and NonTg brain tissue and in 3xTg-AD peripheral blood plasma.<\/p>\n<h3 class=\"wp-block-heading\">Conclusion<\/h3>\n<p>Taken together, our results are the first to demonstrate that despite an extended recovery period, exposure to glyphosate elicits long-lasting pathological consequences. As glyphosate use continues to rise, more research is needed to elucidate the impact of this herbicide and its metabolites on the human brain, and their potential to contribute to dysfunctions observed in neurodegenerative diseases.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/herbicide-neuroinflammation-alzheimers-28182\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: New research reveals that glyphosate, a widely used herbicide, can cause lasting brain inflammation and accelerate Alzheimer\u2019s-like pathology in mice. Even short-term exposure resulted in persistent inflammatory markers and &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=133553\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-133553","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/133553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=133553"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/133553\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=133553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=133553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=133553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}