{"id":134018,"date":"2024-12-06T15:47:49","date_gmt":"2024-12-06T08:47:49","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=134018"},"modified":"2024-12-06T15:47:49","modified_gmt":"2024-12-06T08:47:49","slug":"adult-neurogenesis-fuels-verbal-learning-and-memory","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=134018","title":{"rendered":"Adult Neurogenesis Fuels Verbal Learning and Memory"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Adult neurogenesis, the creation of new brain cells, supports verbal learning and memory. Using brain tissue from epilepsy patients, researchers discovered a direct link between fewer immature brain cells and cognitive decline, particularly in verbal learning and memory.<\/p>\n<p>This work highlights the potential for therapies like exercise or drugs to boost neurogenesis and improve cognitive function in conditions like epilepsy, Alzheimer\u2019s, and aging. The findings underscore the value of studying human brain tissue to uncover insights not visible in animal models.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li>Neurogenesis slows dramatically during the first 20 years of epilepsy, correlating with declines in verbal learning and memory.<\/li>\n<li>Human neurogenesis plays a unique role in verbal learning and memory, unlike visuospatial learning in animals.<\/li>\n<li>Boosting neurogenesis could offer therapeutic potential for cognitive decline in epilepsy, Alzheimer\u2019s, and aging.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>USC<\/p>\n<p><strong>Why do adults make new brain cells? <\/strong><\/p>\n<p>A new study published in\u00a0<em>Cell Stem Cell<\/em>\u00a0provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear.<\/p>\n<p>This discovery could point to new approaches to restore cognitive function.\u00a0<\/p>\n<p>The study, led by scientists from USC Stem Cell and the\u00a0USC Neurorestoration Center\u00a0at the Keck School of Medicine of USC, relied on brain tissue from patients with drug-resistant cases of mesial temporal lobe epilepsy (MTLE), which involves seizures as well as accelerated cognitive decline.\u00a0<\/p>\n<p>\u201cTreating patients with epilepsy allows us to investigate the purpose of generating new neurons in our brains.\u00a0We observe that one of reasons is to learn from the conversations we have\u201d said co-corresponding author\u00a0Michael Bonaguidi, an associate professor of stem cell biology and regenerative medicine, gerontology, biochemistry and molecular medicine, biomedical engineering, and neurological surgery, and assistant director of the USC Neurorestoration Center.\u00a0<\/p>\n<p>\u201cThese findings are clearly important for all people who suffer from learning and cognitive decline, but they are also specifically relevant to the epilepsy patients who participated in the research,\u201d added co-corresponding author Charles Liu, a professor of neurological surgery, neurology, and biomedical engineering, director of the USC Neurorestoration Center, and director of the\u00a0USC Epilepsy Care Consortium.<\/p>\n<p>In the study, first authors Aswathy Ammothumkandy and Luis Corona from USC and their collaborators investigated how the process of making new brain cells\u2014called neurogenesis\u2014affects different types of cognitive decline during the progression of MTLE.<\/p>\n<p>The researchers found that MTLE patients experience cognitive decline in many areas including verbal learning and memory, intelligence, and visuospatial skills.<\/p>\n<p>For verbal learning and memory, as well as for intelligence, patients undergo a dramatic decline during the first 20 years of seizures. During those same two decades, neurogenesis slows to the point where immature brain cells became nearly undetectable.\u00a0<\/p>\n<p>Based on these observations, the scientists searched for links between the number of immature brain cells and the major areas of MTLE-related cognitive decline. They found the strongest association occurs between the declining number of immature brain cells and verbal learning and memory.\u00a0<\/p>\n<p>This is a surprising finding because neurogenesis levels in rodents and other lab animals contribute to a different type of learning and memory using visuospatial skills. The role of neurogenesis in verbal learning and memory highlights the value of studying human brain tissue.<\/p>\n<p>These highly valuable surgical specimens were generously donated by patients of the\u00a0Rancho\u00a0Los\u00a0Amigos\u00a0Epilepsy Center- a unique resource in the public safety-net health system advancing health care and research equity for the underinsured population in the region.<\/p>\n<p>During the complex operations, the neurosurgeons carefully removed the affected hippocampus in one piece, curing the majority of the patients of their seizures.<\/p>\n<p>\u201cOur study provides the first cellular evidence of how neurogenesis contributes to human cognition\u2014in this case, verbal learning and memory,\u201d said Bonaguidi.<\/p>\n<p>\u201cThis work opens a gateway for future studies exploring ways to improve verbal learning and memory by boosting neurogenesis, possibly through exercise or therapeutic drugs. Those approaches could help not only patients with MTLE, Alzheimer\u2019s disease and dementia, but also all of us with aging brains.\u201d<\/p>\n<p>Neuropsychologist Jason Smith from the Medical University of South Carolina is also a co-corresponding author. Additional authors are: Kristine Ravina, Victoria Wolseley, Jeremy Nelson, Nadiya Atai, Aidin Abedi, Lina D\u2019Orazio, Alisha Cayce, Carol McClearly, George Nune, Laura Kalayjian, Darrin Lee, Brian Lee, Christianne Heck, Robert Chow, and Jonathan Russin from USC; Nora Jimenez from\u00a0Los\u00a0Angeles\u00a0General Medical\u00a0Center;\u00a0Michelle Armacost from USC and\u00a0Rancho\u00a0Los\u00a0Amigos\u00a0National\u00a0Rehabilitation\u00a0Center;\u00a0and Virginia Zuverza-Chavarria from\u00a0Rancho\u00a0Los\u00a0Amigos\u00a0National\u00a0Rehabilitation\u00a0Center.<\/p>\n<p><strong>Funding: <\/strong>Thirty percent of this work was supported by federal funding from the National Institutes of Health (grants R56AG064077, R01AG076956, and U01MH098937).<\/p>\n<p>Additional support came from the Donald\u00a0E.\u00a0and\u00a0Delia\u00a0B.Baxter\u00a0Foundation,\u00a0L.K.\u00a0Whittier\u00a0Foundation, Simon-Strauss\u00a0Foundation,\u00a0Cure\u00a0Alzheimer\u2019s\u00a0Fund,\u00a0Eli\u00a0andEdythe\u00a0Broad\u00a0Foundation, USC\u00a0Neurorestoration\u00a0Center, Rudi\u00a0Schulte\u00a0Research Institute, American Epilepsy Society, and California Institute for Regenerative Medicine.<\/p>\n<h2 class=\"wp-block-heading\">About this neurogenesis, learning, and memory research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#1d717c686f7c3371787f717c737e5d70787933686e7e33787968\" target=\"_blank\" rel=\"noreferrer noopener\">Laura LeBlanc<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/med.usc.edu\" target=\"_blank\" rel=\"noreferrer noopener\">USC<\/a><br \/><strong>Contact: <\/strong>Laura LeBlanc \u2013 USC<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/dx.doi.org\/10.1016\/j.stem.2024.11.002\" target=\"_blank\" rel=\"noreferrer noopener\">Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression<\/a>\u201d by Michael Bonaguidi et al. <em>Cell Stem Cell<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression<\/strong><\/p>\n<p>Mesial temporal lobe epilepsy (MTLE) is a syndromic disorder presenting with seizures and cognitive comorbidities. Although seizure etiology is increasingly understood, the pathophysiological mechanisms contributing to cognitive decline and epilepsy progression remain less recognized.<\/p>\n<p>We have previously shown that adult hippocampal neurogenesis dramatically declines in MTLE patients with increased disease duration. Here, we investigate when multiple cognitive domains become affected during epilepsy progression and how human neurogenesis levels contribute to it.<\/p>\n<p>We find that intelligence, verbal learning, and memory decline at a critical period of 20 years disease duration. In contrast to rodents, the number of human immature neurons positively associates with auditory verbal, rather than visuospatial, learning and memory. Moreover, this association does not apply to mature granule neurons.<\/p>\n<p>Our study provides cellular evidence of how adult neurogenesis corresponds with human cognition and signifies an opportunity to advance regenerative medicine for patients with MTLE and other cognitive disorders.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/neurogenesis-learning-memory-28190\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Adult neurogenesis, the creation of new brain cells, supports verbal learning and memory. Using brain tissue from epilepsy patients, researchers discovered a direct link between fewer immature brain cells &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=134018\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-134018","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/134018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=134018"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/134018\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=134018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=134018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=134018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}