{"id":134285,"date":"2024-12-07T09:04:51","date_gmt":"2024-12-07T02:04:51","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=134285"},"modified":"2024-12-07T09:04:51","modified_gmt":"2024-12-07T02:04:51","slug":"cutting-back-on-one-amino-acid-increases-lifespan-in-middle-aged-mice-up-to-33-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=134285","title":{"rendered":"Cutting Back on One Amino Acid Increases Lifespan in Middle-Aged Mice Up to 33% : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Research in mice shows limited intakes of one particular essential amino acid can slow the impacts of aging and even lengthen their lifespan.<\/p>\n<p>Scientists are now wondering if these findings could help people improve their longevity and quality of life.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Isoleucine is one of three branched-chain amino acids we use to build proteins in our bodies. It is essential for our survival, but since our cells can&#8217;t produce it from scratch, we have to get it from sources like eggs, dairy, soy protein, and meats.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>But there can always be too much of a good thing. <a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(21)00166-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413121001662%3Fshowall%3Dtrue\">Earlier research<\/a> using data from a 2016-2017 survey of Wisconsin residents had found dietary isoleucine levels were linked with metabolic health and that people with higher BMIs were generally consuming much greater quantities of the amino acid.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Different components of your diet have value and impact beyond their function as a calorie, and we&#8217;ve been digging in on one component that many people may be eating too much of,&#8221; metabolism researcher Dudley Lamming from the University of Wisconsin, US, who was involved in both studies, <a href=\"https:\/\/news.wisc.edu\/mice-eating-less-of-specific-amino-acid-overrepresented-in-diet-of-obese-people-live-longer-healthier\/\">explained<\/a> in 2023 when the newest findings were published.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;It&#8217;s interesting and encouraging to think a dietary change could still make such a big difference in lifespan and what we call &#8216;healthspan,&#8217; even when it started closer to mid-life.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>In the most recent study, a genetically diverse group of mice was fed either a diet containing 20 common amino acids as a control, a diet where all amino acids were reduced by about two-thirds, or a diet where only isoleucine was reduced by the same amount.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The mice were around six months old at the start of the study, which is the equivalent age of a 30-year-old person. They could eat as much as they wanted, but only from the specific kind of food provided to their group.<\/p>\n<figure id=\"attachment_146146\" aria-describedby=\"caption-attachment-146146\" style=\"width: 642px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/12\/SoyFoods642.jpg\" alt=\"Various soy foods\" width=\"642\" height=\"500\" class=\"size-full wp-image-146146\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/12\/SoyFoods642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/12\/SoyFoods642-533x415.jpg 533w, https:\/\/www.sciencealert.com\/images\/2024\/12\/SoyFoods642-600x467.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-146146\" class=\"wp-caption-text\">Our cells can&#8217;t produce isoleucine from scratch \u2013 we have to get it from foods such as soy protein. (<a href=\"https:\/\/www.canva.com\/photos\/MAFMZwKkZ1w\/\">ArtStudio Images\/Canva<\/a>)<\/figcaption><\/figure>\n<p>Restricting dietary isoleucine increased the lifespan and healthspan of the mice, reduced their frailty, and promoted leanness and glycemic control. Male mice had their lifespans increased 33 percent compared to those whose isoleucine was not restricted, and females had a 7 percent increase.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>These mice also scored better in 26 measures of health, including muscle strength, endurance, blood sugar levels, tail use, and hair loss.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The male mice in this group had less age-related prostate enlargement, and were less likely to develop the cancerous tumors that are common in the diverse mice strains.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Curiously, the mice given low isoleucine food also ate significantly more calories than the others. But rather than gaining weight, they actually burned more energy and maintained leaner body weights, even though their activity levels were no different.<\/p>\n<figure id=\"attachment_112585\" aria-describedby=\"caption-attachment-112585\" style=\"width: 996px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2023\/11\/fx1_lrg.jpg\" alt=\"Graphical abstract shows dietary isoleucine was restricted by 67%, charts showing blood glucose and body weight declining over time \/ age respectively, reduced frailty and cancer, increased lifespan (survival improved by 33 percent)\" width=\"996\" height=\"996\" class=\"wp-image-112585 size-full\" srcset=\"https:\/\/www.sciencealert.com\/images\/2023\/11\/fx1_lrg.jpg 996w, https:\/\/www.sciencealert.com\/images\/2023\/11\/fx1_lrg-642x642.jpg 642w, https:\/\/www.sciencealert.com\/images\/2023\/11\/fx1_lrg-415x415.jpg 415w, https:\/\/www.sciencealert.com\/images\/2023\/11\/fx1_lrg-768x768.jpg 768w, https:\/\/www.sciencealert.com\/images\/2023\/11\/fx1_lrg-600x600.jpg 600w\" sizes=\"auto, (max-width: 996px) 100vw, 996px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-112585\" class=\"wp-caption-text\">A visual summary of the impact the reduced isoleucine diet had on mice in the study. (<a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(23)00374-1\">Green et al., C<em>ell Metabolism, <\/em>2023)<\/a><\/figcaption><\/figure>\n<p>The researchers think restricting isoleucine in humans, either by diet or pharmaceutical means, has the potential to yield similar anti-aging effects &#8211; although, as with all mice studies, we won&#8217;t know for sure until it&#8217;s actually tested in humans.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>This is easier said than done. Although the food provided to the mice was controlled, the researchers noted that diet is an incredibly complex chemical reaction, and there may be other dietary components involved in producing these results.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Restricting protein intake in general, for instance, has detrimental effects on the body, mouse or human. Translating this research for real-world human use is more complicated than just reducing intake of high-protein foods, even though this is the simplest way to limit isoleucine intake.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The amino acid restriction level was constant in all experiments, and they acknowledge that more fine-tuning may be required for optimum effects across different mice strains and sexes \u2013 when it comes to diet, one size does not fit all.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We can&#8217;t just switch everyone to a low-isoleucine diet,&#8221; Lamming <a href=\"https:\/\/news.wisc.edu\/mice-eating-less-of-specific-amino-acid-overrepresented-in-diet-of-obese-people-live-longer-healthier\/\">said<\/a>.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;But narrowing these benefits down to a single amino acid gets us closer to understanding the biological processes and maybe potential interventions for humans, like an isoleucine-blocking drug.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The research was published in <a href=\"https:\/\/www.cell.com\/cell-metabolism\/fulltext\/S1550-4131(23)00374-1\"><em>Cell Metabolism<\/em>.<\/a><\/p>\n<p><em>An earlier version of this article was published in November 2023.<\/em><\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/cutting-back-on-one-amino-acid-increases-lifespan-in-middle-aged-mice-up-to-33\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research in mice shows limited intakes of one particular essential amino acid can slow the impacts of aging and even lengthen their lifespan. Scientists are now wondering if these findings &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=134285\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-134285","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/134285","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=134285"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/134285\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=134285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=134285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=134285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}