{"id":134558,"date":"2024-12-08T02:21:46","date_gmt":"2024-12-07T19:21:46","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=134558"},"modified":"2024-12-08T02:21:46","modified_gmt":"2024-12-07T19:21:46","slug":"ketogenic-diet-enhances-car-t-cancer-therapy","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=134558","title":{"rendered":"Ketogenic Diet Enhances CAR-T Cancer Therapy"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers have found that a ketogenic diet boosts CAR T cell therapy effectiveness by enhancing tumor control and survival in mice with lymphoma. The key is beta-hydroxybutyrate (BHB), a metabolite produced during ketosis, which CAR T cells prefer as an energy source over glucose. Laboratory models showed that BHB supplementation led to complete cancer remission in most mice and enhanced CAR T cell expansion.<\/p>\n<p>Translational studies in human samples confirmed that higher BHB levels correlate with better CAR T cell performance. This approach is now being tested in a Phase I clinical trial for lymphoma patients. If successful, this low-toxicity, cost-effective strategy could significantly improve cancer immunotherapy outcomes.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Ketogenic Boost:<\/strong> A ketogenic diet increased tumor control and survival in lymphoma-afflicted mice by enhancing CAR T cell efficacy.<\/li>\n<li><strong>BHB Preference:<\/strong> CAR T cells thrive on beta-hydroxybutyrate (BHB), a metabolite from ketosis, outperforming glucose as a fuel source.<\/li>\n<li><strong>Clinical Trials:<\/strong> A Phase I trial is testing BHB supplementation in lymphoma patients receiving CAR T therapy to validate these findings.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Pennsylvania<\/p>\n<p>A simple dietary supplement may provide a new approach to boost CAR T cell function, according to a study from researchers in the\u00a0Perelman School of Medicine at the University of Pennsylvania\u00a0and\u00a0Penn Medicine\u2019s Abramson Cancer Center.<\/p>\n<p>While the approach needs to be assessed in clinical trials, the early research, shared in a press briefing today at the\u00a066th American Society of Hematology (ASH) Annual Meeting and Exposition\u00a0(Abstract 4), hints at a potentially cost-effective strategy to improve CAR T cell function and cancer-fighting abilities. \u00a0\u00a0<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106856\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience.jpg\" alt=\"This shows keto foods and cancer cells.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/keto-cancer-cart-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">They found improved tumor control and survival in the mice receiving a ketogenic diet compared to all other diets. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>CAR T cell therapy\u00a0is a personalized treatment approach, pioneered at Penn Medicine, that reprograms patients\u2019 own immune cells to kill their cancer.<\/p>\n<p>\u201cThousands of patients with blood cancers have been successfully treated with CAR T cell therapy, but it still doesn\u2019t work for everyone,\u201d said co-lead author\u00a0Shan Liu, PhD, a postdoctoral fellow who presented the study at ASH.<\/p>\n<p>\u201cWe took an outside-the-box approach to improve CAR T cell therapy, by targeting T cells through diet rather than further genetic engineering.\u201d<\/p>\n<p>Liu co-led the study with\u00a0Puneeth Guruprasad, PhD, who earned his PhD at Penn and is now a medical student in the Perelman School of Medicine. The lead authors worked under the mentorship of co-senior authors\u00a0Marco Ruella, MD, an assistant professor of Hematology-Oncology, a researcher with the Center for Cellular Immunotherapies and the scientific director of Penn Medicine\u2019s Lymphoma Program; and\u00a0Maayan Levy, PhD, an assistant professor of Microbiology.<\/p>\n<p><strong>CAR T cells prefer BHB as a fuel source<\/strong><\/p>\n<p>First, the research team tested the effect of several different diets, including ketogenic, high-fiber, high-fat, high-protein, high cholesterol, and a control diet, on CAR T cell\u2019s tumor-fighting capabilities using a mouse model of diffuse-large B-cell lymphoma. They found improved tumor control and survival in the mice receiving a ketogenic diet compared to all other diets.<\/p>\n<p>In subsequent studies, they found higher levels of beta-hydroxybutyrate (BHB), a metabolite produced by the liver in response to a ketogenic diet, was a key mediator of this effect.<\/p>\n<p>The research builds on\u00a0previous work from Levy\u2019s team, which found that BHB strongly suppressed the growth of colorectal tumors in lab experiments.<\/p>\n<p>\u201cOur theory is that CAR T cells prefer BHB as a fuel source rather than standard sugars in our body, such as glucose,\u201d Guruprasad said. \u201cSo, increasing the levels of BHB in the body gives the CAR T cells more power to take out the cancer cells.\u201d<\/p>\n<p><strong>Translational studies in patient samples and healthy volunteers<\/strong><\/p>\n<p>Next, the research team tested a BHB supplement combined with CAR T cell therapy in laboratory models of human cancer (on a standard diet); the results showed complete obliteration of the cancer in the vast majority of mice and resulted in higher CAR T cell expansion and activation.<\/p>\n<p>To see if BHB, which occurs naturally at various level in our bodies, had a similar effect in humans, the team assessed blood samples from patients who had recently received CAR T cell therapy and found that greater BHB levels were associated with better CAR T cell expansion in patients.<\/p>\n<p>They also looked at T cells of healthy volunteers who took a BHB supplement and found similar changes in how normal T cells generated energy after exposure to BHB.<\/p>\n<p>Past studies across several cancer types have looked at the impact of dietary interventions, such as a high-fiber diet, on the response to cancer immunotherapy, however the mechanism behind the BHB effect in this study appears to stem from metabolic changes in the blood, rather than via the gut microbiome, as in the case of a high-fiber diet.<\/p>\n<p><strong>Next steps and potential impact<\/strong><\/p>\n<p>The theory that BHB supplementation could improve response to CAR T cell therapy is being tested in a\u00a0Phase I clinical trial\u00a0at Penn Medicine\u2019s Abramson Cancer Center.<\/p>\n<p>\u201cWe\u2019re talking about an intervention that is relatively cheap and has low toxicity potential,\u201d Levy said.<\/p>\n<p>\u201cIf the clinical trial data pans out, I\u2019m excited to think about how a fairly simple approach like this could be combined with dietary interventions or other, more traditional approaches, to enhance the anti-cancer effect.\u201d<\/p>\n<p>The clinical trial, led by principal investigator\u00a0Elise Chong, MD, an assistant professor of Hematology-Oncology, will soon begin enrolling patients with relapsed or refractory large B-cell lymphoma who are receiving commercially available anti-CD19 CAR T cell therapy as part of their treatment.<\/p>\n<p>\u201cAs a physician and scientist, I share my patients\u2019 excitement for potential new strategies to better treat their cancer, and I\u2019m thrilled to see this research move from the lab bench to translational studies and now to a clinical trial,\u201d Ruella said.<\/p>\n<p>\u201cHowever, we want to emphasize that, at this point, the research is still preliminary, and we\u2019re not making any dietary or supplement recommendations to patients based on this study until we have definitive clinical evidence.\u201d<\/p>\n<p><strong>Funding: <\/strong>The study was partly funded by the Penn-CHOP Microbiome Core.<\/p>\n<h2 class=\"wp-block-heading\">About this brain cancer and diet research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#e78a8286808689c99586828c82a7978289898a82838e848e8982c99297828989c9828392\" target=\"_blank\" rel=\"noreferrer noopener\">Meagan Raeke<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/pennmedicine.upenn.edu\" target=\"_blank\" rel=\"noreferrer noopener\">University of Pennsylvania<\/a><br \/><strong>Contact: <\/strong>Meagan Raeke \u2013 University of Pennsylvania<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>The findings will be presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/keto-bhb-cancer-therapy-28205\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers have found that a ketogenic diet boosts CAR T cell therapy effectiveness by enhancing tumor control and survival in mice with lymphoma. 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