{"id":135130,"date":"2024-12-09T15:58:46","date_gmt":"2024-12-09T08:58:46","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=135130"},"modified":"2024-12-09T15:58:46","modified_gmt":"2024-12-09T08:58:46","slug":"promising-new-malaria-vaccine-can-be-injected-by-mosquito-bite-sciencealert","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=135130","title":{"rendered":"Promising New Malaria Vaccine Can Be Injected by Mosquito Bite : ScienceAlert"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p>Mosquitoes are normally associated with <a href=\"https:\/\/www.sciencealert.com\/malaria-causing-parasites-have-mutated-in-a-way-that-s-allowing-them-to-escape-detection\">spreading malaria<\/a> rather than preventing it, but in a new study scientists have used the insects to administer a promising new vaccine that could offer much better protection against the disease than current options.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>It&#8217;s the second generation of this particular vaccine type, and the improvement shown in this study is significant: eight out of nine young adults given the new vaccine were protected against  <a href=\"https:\/\/www.sciencealert.com\/malaria\" class=\"lar_link lar_link_outgoing\" data-linkid=\"73073\" data-postid=\"144774\" rel=\"nofollow noopener\" target=\"_self\">malaria<\/a>, compared with one out of eight given the existing one.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The new vaccine, developed by researchers from Leiden University and Radboud University in the Netherlands, uses a genetically weakened version of the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Plasmodium_falciparum\"><em>Plasmodium falciparum<\/em><\/a> parasite that causes malaria in humans. This version (GA2) doesn&#8217;t trigger malaria, but does prepare the body to guard against it.<\/p>\n<figure id=\"attachment_144777\" aria-describedby=\"caption-attachment-144777\" style=\"width: 642px\" class=\"wp-caption alignnone\"><img decoding=\"async\" src=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/VaccineChart.jpg\" alt=\"Vaccine chart\" width=\"642\" height=\"464\" class=\"wp-image-144777 size-full\" srcset=\"https:\/\/www.sciencealert.com\/images\/2024\/11\/VaccineChart.jpg 642w, https:\/\/www.sciencealert.com\/images\/2024\/11\/VaccineChart-574x415.jpg 574w, https:\/\/www.sciencealert.com\/images\/2024\/11\/VaccineChart-600x434.jpg 600w\" sizes=\"auto, (max-width: 642px) 100vw, 642px\" loading=\"lazy\"\/><figcaption id=\"caption-attachment-144777\" class=\"wp-caption-text\">The new vaccine (GA2) offered strong protection against malaria infection. (Larners et al., <em>New England Journal of Medicine<\/em>, 2024)<\/figcaption><\/figure>\n<p>&#8220;These crippled parasites are administered through a mosquito bite and reach the human liver as usual,&#8221; <a href=\"https:\/\/www.radboudumc.nl\/en\/news-items\/2024\/betere-bescherming-tegen-malaria-door-inenting-met-genetisch-verzwakte-parasieten\">says<\/a> vaccinologist Meta Roestenberg, from Leiden University. &#8220;But because of the gene turned off, this parasite cannot complete its development in the liver, cannot enter the bloodstream, and thus cannot cause disease symptoms.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;Meanwhile, this crippled infection does create a strong immune response in the liver, which can protect the person from a real malaria infection in the future.&#8221;<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Having the parasite take longer to develop in the body seems to help: with GA2, <em>P. falciparum<\/em> takes almost a week to mature inside the liver, compared with 24 hours for GA1, the previous version. That gives the <a href=\"https:\/\/www.sciencealert.com\/immune-cells-patrolling-the-human-eye-are-not-what-scientists-thought\">immune system<\/a> more time to recognize what it is, and work on fighting back.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>The GA2 vaccine triggered a bigger and more diverse set of immune cells, the study showed, which may help explain its much improved effectiveness. Understanding why it works so well will give researchers a better idea of how to further refine it.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Observed side effects were relatively minor, the researchers report, and mostly involved redness and itchiness around the <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/mosquito-bites\/symptoms-causes\/syc-20375310\">mosquito bites<\/a>. All participants were put on a course of anti-malaria drugs after the study data had been collected.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>Progress continues to be made in tackling malaria, whether it&#8217;s <a href=\"https:\/\/www.radboudumc.nl\/en\/news-items\/2024\/betere-bescherming-tegen-malaria-door-inenting-met-genetisch-verzwakte-parasieten\">cutting it off<\/a> at the source or <a href=\"https:\/\/www.sciencealert.com\/malaria-could-be-eliminated-by-2040-new-vaccine-offers-hope\">protecting the human body<\/a>. However, we&#8217;re still seeing <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria\">almost 250 million cases per year<\/a>, and hundreds of thousands of deaths \u2013 and current vaccines <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(21)00943-0\/fulltext\">only protect<\/a> around 50-77 percent of the population, often for not much longer than a year.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>As for the mosquito bite delivery system, this isn&#8217;t <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abn9709\">particularly unusual<\/a> for research like this: it&#8217;s useful because it means the the modified parasite is delivered and targeted in the same way as the full-strength version, but <a href=\"https:\/\/resjournals.onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1365-2583.2010.01000.x\">it isn&#8217;t practical<\/a> to use the approach to actually roll out a vaccine to the public.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;In short, the test with our new crippled GA2 parasite performs very well,&#8221; <a href=\"https:\/\/www.radboudumc.nl\/en\/news-items\/2024\/betere-bescherming-tegen-malaria-door-inenting-met-genetisch-verzwakte-parasieten\">says<\/a> clinical microbiologist Matthew McCall, from Radboud University.<\/p>\n<p><!-- START single\/mrec --><br \/>\n<!-- END single\/mrec --><\/p>\n<p>&#8220;We now plan to test vaccination with similar GA2 parasites in real life.&#8221;<\/p>\n<p>The research has been published in the <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2313892\"><em>New England Journal of Medicine<\/em><\/a>.<\/p>\n<\/p><\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/www.sciencealert.com\/promising-new-malaria-vaccine-can-be-injected-by-mosquito-bite\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mosquitoes are normally associated with spreading malaria rather than preventing it, but in a new study scientists have used the insects to administer a promising new vaccine that could offer &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=135130\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-135130","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/135130","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=135130"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/135130\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=135130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=135130"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=135130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}