{"id":135717,"date":"2024-12-11T06:36:06","date_gmt":"2024-12-10T23:36:06","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=135717"},"modified":"2024-12-11T06:36:06","modified_gmt":"2024-12-10T23:36:06","slug":"diets-that-reduce-brain-iron-may-delay-cognitive-decline","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=135717","title":{"rendered":"Diets That Reduce Brain Iron May Delay Cognitive Decline"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>New research suggests that certain nutrients may lower iron buildup in the brain, a factor linked to cognitive decline in aging. Excess non-heme iron, which accumulates over time, contributes to oxidative stress and can impair memory and executive function.<\/p>\n<p>Over three years, participants with higher intake of antioxidants, vitamins, and iron-chelating nutrients showed less brain iron accumulation and better cognitive performance. These findings highlight the potential of diets like the Mediterranean or DASH to support brain health and combat age-related cognitive decline.<\/p>\n<p><strong>Key Facts:<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Iron\u2019s Role:<\/strong> Excess brain iron, especially non-heme iron, is linked to poor memory and executive function in aging.<\/li>\n<li><strong>Nutritional Impact:<\/strong> Higher intake of antioxidants, vitamins, and iron-chelating nutrients reduces brain iron buildup.<\/li>\n<li><strong>Dietary Potential:<\/strong> Diets rich in these nutrients, such as the Mediterranean or DASH diets, may protect against cognitive decline.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Kentucky<\/p>\n<p><strong>Researchers at the University of Kentucky have found that incorporating specific nutrients into a regular diet may reduce iron buildup in the brain \u2014 a factor associated with cognitive decline in normal aging.<\/strong><\/p>\n<p>The study,\u00a0titled \u201cExploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study,\u201d was published in\u00a0<em>Neurobiology of Aging.<\/em><\/p>\n<p>The work was supported by multiple grants from the National Institutes of Health\u2019s\u00a0National Institute on Aging\u00a0and\u00a0National Institute of Neurological Disorders and Stroke.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-106957\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience.jpg\" alt=\"This shows a brain and healthy food.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/brain-diet-iron-cognition-neuroscience-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">They measured brain iron levels with a specific MRI technique called quantitative susceptibility mapping. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>\u201cIt\u2019s crucial to understand how diet and other lifestyle factors impact the risk of Alzheimer\u2019s and related dementias as we age,\u201d said Brian Gold, Ph.D., professor in the Department of Neuroscience in the\u00a0College of Medicine, faculty in the\u00a0Sanders-Brown Center on Aging\u00a0and principal investigator of the study.<\/p>\n<p>\u201cThis study is an example of how we can encourage healthier lifestyle choices to help combat some risk factors that can affect brain health,\u201d said Gold.<\/p>\n<p>In this project, researchers specifically looked at non-heme iron, which is critical for brain health. This type of iron does not bind with storage proteins and, with age and in excess, can contribute to oxidative stress, potentially affecting neuronal integrity and cognition.<\/p>\n<p>Excessive brain iron has been linked to poor cognitive performance, even in normal aging.<\/p>\n<p>\u201cDespite mounting evidence connecting iron overload to negative cognitive outcomes, there are currently no established methods for reducing brain iron accumulation in older adults,\u201d said Valentinos Zachariou, Ph.D., an assistant professor in the Department of Behavioral Science in the College of Medicine and first author of the paper.<\/p>\n<p>This study builds on the research team\u2019s\u00a0previous work\u00a0that found that higher intake of antioxidants, vitamins, iron-chelating nutrients and polyunsaturated fatty acids correlated with lower brain iron levels and better working memory performance.<\/p>\n<p>\u201cWe still had important questions that remained unanswered in that initial investigation, particularly regarding the long-term effectiveness of these nutrients and their potential to reduce age-related brain iron accumulation,\u201d said Zachariou.<\/p>\n<p>For a follow-up study, Gold and Zachariou worked with the same research team, including the Department of Neuroscience\u2019s Colleen Papas, Ph.D., Christopher Bauer, Ph.D., and Elayna Seago.<\/p>\n<p>The team reassessed brain iron concentrations approximately three years later in the same cohort of older adults. They measured brain iron levels with a specific MRI technique called quantitative susceptibility mapping.<\/p>\n<p>Researchers also analyzed a month\u2019s worth of dietary information and cognitive performance, which was evaluated using neuropsychological tests of episodic memory (memories of specific events) and executive function.<\/p>\n<p>\u201cOur results revealed a broad network of cortical and subcortical brain regions where iron accumulation occurred over the three-year period,\u201d said Zachariou.<\/p>\n<p>\u201cThese regional increases in iron levels were associated with poorer episodic memory and executive function at the follow-up time-point.\u201d<\/p>\n<p>\u201cHowever, participants who had higher baseline intake of antioxidants, vitamins, iron-chelating nutrients, and polyunsaturated fatty acids showed significantly less iron accumulation over the three-year period,\u201d said Gold.<\/p>\n<p>The research team said the findings offer valuable insights for future clinical trials aimed at evaluating the impact of similar nutritional intake on brain iron accumulation and cognitive function.<\/p>\n<p>Further study of iron accumulation and cognition effects of healthy diets rich in the nutrients examined in this study, such as the Mediterranean or DASH diets, would be highly beneficial.<\/p>\n<p><strong>Funding: <\/strong>Research reported in this publication was supported by the\u00a0National Institute on Aging\u00a0of the National Institutes of Health under Award Numbers\u00a0R01AG055449, R01AG068055, P30AG072946 and P30AG028383; by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number RF1NS122028; and the Office of Research Infrastructure Programs of the National Institutes of Health under Award Number\u00a0S10OD023573.<\/p>\n<p>The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.<\/p>\n<h2 class=\"wp-block-heading\">About this diet and brain health research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author:<\/strong><a href=\"https:\/\/www.research.uky.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong> <\/strong>Lindsay Travis<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/www.research.uky.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Kentucky<\/a><br \/><strong>Contact: <\/strong>Lindsay Travis \u2013 University of Kentucky<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research:<\/strong> Open access.<br \/>\u201c<a href=\"https:\/\/doi.org\/10.1016\/j.neurobiolaging.2024.10.006\" target=\"_blank\" rel=\"noreferrer noopener\">Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study<\/a>\u201d by Brian Gold et al. <em>Neurobiology of Aging<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study<\/strong><\/p>\n<p>This study evaluated longitudinal brain iron accumulation in older adults, its association with cognition, and the role of specific nutrients in mitigating iron accumulation.<\/p>\n<p>MRI-based, quantitative susceptibility mapping estimates of brain iron concentration were acquired from seventy-two healthy older adults (47 women, ages 60\u201386) at a baseline timepoint (TP1) and a follow-up timepoint (TP2) 2.5\u20133.0 years later.<\/p>\n<p>Dietary intake was evaluated at baseline using a validated questionnaire. Cognitive performance was assessed at TP2 using the uniform data set (Version 3) neuropsychological tests of episodic memory (MEM) and executive function (EF).<\/p>\n<p>Voxel-wise, linear mixed-effects models, adjusted for longitudinal gray matter volume alterations, age, and several non-dietary lifestyle factors revealed brain iron accumulation in multiple subcortical and cortical brain regions, which was negatively associated with both MEM and EF performance at T2.<\/p>\n<p>However, consumption of specific dietary nutrients at TP1 was associated with reduced brain iron accumulation.<\/p>\n<p>Our study provides a map of brain regions showing iron accumulation in older adults over a short 2.5-year follow-up and indicates that certain dietary nutrients may slow brain iron accumulation.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/diets-brain-iron-cognition-28228\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: New research suggests that certain nutrients may lower iron buildup in the brain, a factor linked to cognitive decline in aging. Excess non-heme iron, which accumulates over time, contributes &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=135717\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-135717","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/135717","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=135717"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/135717\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=135717"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=135717"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=135717"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}