{"id":137098,"date":"2024-12-14T23:08:58","date_gmt":"2024-12-14T16:08:58","guid":{"rendered":"https:\/\/hotvideos24.online\/?p=137098"},"modified":"2024-12-14T23:08:58","modified_gmt":"2024-12-14T16:08:58","slug":"mini-brains-reveal-new-insights-into-mitochondrial-brain-disorders","status":"publish","type":"post","link":"https:\/\/hotvideos24.online\/?p=137098","title":{"rendered":"Mini-Brains Reveal New Insights Into Mitochondrial Brain Disorders"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<\/p>\n<div>\n<p><strong>Summary: <\/strong>Researchers have created mini-brains to study how mitochondrial failure impacts brain cells, opening new possibilities for treating severe conditions like epilepsy. These brain organoids mimic real disease processes, allowing scientists to observe mitochondrial dysfunction and test potential treatments.<\/p>\n<p>Beyond epilepsy, the research could improve understanding of conditions like Alzheimer\u2019s and Parkinson\u2019s diseases, which are also linked to mitochondrial issues. Mini-brains offer a powerful tool for studying disease progression, testing personalized therapies, and identifying novel drug targets.<\/p>\n<p><strong>Key Facts<\/strong><\/p>\n<ul class=\"wp-block-list\">\n<li><strong>Mini-Brain Innovation:<\/strong> Mini-brains mimic mitochondrial dysfunction in brain diseases.<\/li>\n<li><strong>Therapeutic Testing:<\/strong> They allow real-time study of disease progression and personalized treatments.<\/li>\n<li><strong>Broader Impact:<\/strong> Findings could aid research on epilepsy, Alzheimer\u2019s, and Parkinson\u2019s diseases.<\/li>\n<\/ul>\n<p><strong>Source: <\/strong>University of Bergen<\/p>\n<p><strong>Researchers at the University of Bergen have used advanced stem cell technology to develop mini-brains, also called brain organoids, that can mimic disease processes caused by mitochondrial failure. <\/strong><\/p>\n<p>This could open new avenues for treating serious brain diseases such as epilepsy.<\/p>\n<p>Mitochondria, known as the powerhouses of cells, are crucial for supplying the brain with energy. When mitochondrial function fails, this can lead to serious disorders in the brain, which require a lot of energy to function.<\/p>\n<figure class=\"wp-block-image size-full\"><picture fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-107042\"><source type=\"image\/webp\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence.jpg.webp 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-300x200.jpg.webp 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-770x513.jpg.webp 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-1155x770.jpg.webp 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-370x247.jpg.webp 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-293x195.jpg.webp 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-150x100.jpg.webp 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"800\" src=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence.jpg\" alt=\"This shows mitochondria.\" srcset=\"https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence.jpg 1200w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-300x200.jpg 300w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-770x513.jpg 770w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-1155x770.jpg 1155w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-370x247.jpg 370w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-293x195.jpg 293w, https:\/\/neurosciencenews.com\/files\/2024\/12\/mini-brain-mitochondira-neurosicence-150x100.jpg 150w\" sizes=\"(max-width: 1200px) 100vw, 1200px\"\/> <\/picture><figcaption class=\"wp-element-caption\">The mini-brains offer a valuable model for exploring complex disease processes and testing treatment strategies in a realistic but controlled environment. Credit: Neuroscience News<\/figcaption><\/figure>\n<p>Using mini-brains, a research team led by Kristina Xiao Liang at the Department of Clinical Medicine, University of Bergen, has been able to study how genetic mutations in mitochondria affect brain cells and other cell types.<\/p>\n<p>\u201cThe mini-brains give us a unique opportunity to understand disease mechanisms at the cellular level and test potential treatments. This is a significant step towards developing new therapies for diseases like severe epilepsy,\u201d says Liang.<\/p>\n<p>In addition, the research can\u00a0contribute to a better understanding of other brain diseases such as Alzheimer\u2019s and Parkinson\u2019s disease.<\/p>\n<p>The mini-brains offer a valuable model for exploring complex disease processes and testing treatment strategies in a realistic but controlled environment.<\/p>\n<p>\u201cThese diseases often involve mitochondrial dysfunction that can be studied in the mini-brains. They allow researchers to study disease progression in real time, test personalized therapies, and identify new drug targets.<\/p>\n<p>\u201cWhile they are still under development, they have shown that we can increase our understanding and treatment of these conditions, potentially revolutionizing the field,\u201d says Liang.<\/p>\n<h2 class=\"wp-block-heading\">About this genetics and neurotech research news<\/h2>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Author: <\/strong><a href=\"http:\/\/neurosciencenews.com\/cdn-cgi\/l\/email-protection#c1b1a0b4adefb2aeacaca4b3a7a4ada5b581b4a8a3efafae\" target=\"_blank\" rel=\"noreferrer noopener\">Paul Sommerfeldt<\/a><br \/><strong>Source: <\/strong><a href=\"https:\/\/uib.no\" target=\"_blank\" rel=\"noreferrer noopener\">University of Bergen<\/a><br \/><strong>Contact: <\/strong>Paul Sommerfeldt \u2013 University of Bergen<br \/><strong>Image: <\/strong>The image is credited to Neuroscience News<\/p>\n<p class=\"has-background\" style=\"background-color:#ffffe8\"><strong>Original Research: <\/strong>Open access.<br \/>\u201c<a href=\"https:\/\/doi.org\/10.1002\/advs.202307136\" target=\"_blank\" rel=\"noreferrer noopener\">Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids<\/a>\u201d by Kristina Xiao Liang et al. <em>Advanced Science<\/em><\/p>\n<hr class=\"wp-block-separator has-text-color has-pale-cyan-blue-color has-alpha-channel-opacity has-pale-cyan-blue-background-color has-background\"\/>\n<p><strong>Abstract<\/strong><\/p>\n<p><strong>Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids<\/strong><\/p>\n<p>In this research, a 3D brain organoid model is developed to study POLG-related encephalopathy, a mitochondrial disease stemming from\u00a0<em>POLG<\/em>\u00a0mutations.<\/p>\n<p>Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utilized to generate cortical organoids, which exhibited typical features of the diseases with\u00a0<em>POLG<\/em>\u00a0mutations, such as altered morphology, neuronal loss, and mitochondiral DNA (mtDNA)\u00a0depletion.<\/p>\n<p>Significant dysregulation is also identified in pathways crucial for neuronal development and function, alongside upregulated NOTCH and JAK-STAT signaling pathways.<\/p>\n<p>Metformin treatment ameliorated many of these abnormalities, except for the persistent affliction of inhibitory dopamine-glutamate (DA GLU) neurons.<\/p>\n<p>This novel model effectively mirrors both the molecular and pathological attributes of diseases with\u00a0<em>POLG<\/em>\u00a0mutations, providing a valuable tool for mechanistic understanding and therapeutic screening for POLG-related disorders and other conditions characterized by compromised neuronal mtDNA maintenance and complex I deficiency.<\/p>\n<p> <!-- Form created by Optin Forms plugin by WPKube: create beautiful optin forms with ease! --> <!-- https:\/\/wpkube.com\/ --><!--optinforms-form5-container--> <!-- \/ Optin Forms --> <\/div>\n<p><script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-layout-key=\"-fb+5w+4e-db+86\"\r\n     data-ad-client=\"ca-pub-3711241968723425\"\r\n     data-ad-slot=\"7910942971\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1660802\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<br \/>\n<br \/><a href=\"https:\/\/neurosciencenews.com\/mini-brains-mitochondria-28245\/\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Summary: Researchers have created mini-brains to study how mitochondrial failure impacts brain cells, opening new possibilities for treating severe conditions like epilepsy. These brain organoids mimic real disease processes, allowing &hellip; <a href=\"https:\/\/hotvideos24.online\/?p=137098\" class=\"more-link\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-137098","post","type-post","status-publish","format-standard","hentry","category-health","entry"],"_links":{"self":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/137098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=137098"}],"version-history":[{"count":0,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=\/wp\/v2\/posts\/137098\/revisions"}],"wp:attachment":[{"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=137098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=137098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hotvideos24.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=137098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}